O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMS |
Texto Completo: | https://repositorio.ufms.br/handle/123456789/4238 |
Resumo: | In recent years, the use of medicinal plants has increased in several countries. However, the indiscriminate consumption of medicinal plants poses health risks due to several factors such as ingestion of incorrectly identified plants, overdose, long duration of administration, inadequate combination of plants, as well as contamination by microorganisms and heavy metals. Public policies and regulations have been created in several countries with the aim of valuing and providing safety to the consumer of medicinal plants. Given the above, this dissertation aims to: a) describe the regulations related to the registration and notification of plant drugs, herbal medicines and traditional herbal products, with an emphasis on the quantification of heavy metals; b) carry out an on-site study to verify compliance with regulations regarding the identification, labeling and dosage of plant drugs sold in Campo Grande - MS; and c) investigate the existence of studies on the quantification of heavy metals in medicinal plants listed in the List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS) that have published monographs. According to the in loco results, in the city of Campo Grande - MS, plant drugs from medicinal and herbal plants are freely traded on the streets and markets of that city without identification, proper labeling and dosages. On the streets of the city of Campo Grande - MS, as well as on the internet, medicinal plants are sold with packaging claiming the cure process for various diseases, that is, they do not follow the regulations established by Anvisa. It was found that the quantification of heavy metals has been performed in some medicinal plants listed in RENISUS, as well as other species, however, this information is not considered in the monographs. Macro and microelement analyzes must also be carried out on plant drugs to be commercialized. New updates are needed in relation to the list of medicinal plants in RENISUS, which can significantly contribute to avoiding possible health risks for users and informing sellers of medicinal plants of possible dosages. Given the evidence, it is necessary that several countries improve their inspection and monitoring of heavy metals involving medicinal plants in the form of drugs and plant derivatives, in order to mitigate the vulnerability of the population that consumes these products. In addition, it is necessary to develop monographs of medicinal plants with the inclusion of information regarding the quantification of heavy metals and risk calculations, and comparison of the intake limits for heavy metals established by regulatory agencies. |
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2021-12-23T21:05:19Z2021-12-23T21:05:19Z2021https://repositorio.ufms.br/handle/123456789/4238In recent years, the use of medicinal plants has increased in several countries. However, the indiscriminate consumption of medicinal plants poses health risks due to several factors such as ingestion of incorrectly identified plants, overdose, long duration of administration, inadequate combination of plants, as well as contamination by microorganisms and heavy metals. Public policies and regulations have been created in several countries with the aim of valuing and providing safety to the consumer of medicinal plants. Given the above, this dissertation aims to: a) describe the regulations related to the registration and notification of plant drugs, herbal medicines and traditional herbal products, with an emphasis on the quantification of heavy metals; b) carry out an on-site study to verify compliance with regulations regarding the identification, labeling and dosage of plant drugs sold in Campo Grande - MS; and c) investigate the existence of studies on the quantification of heavy metals in medicinal plants listed in the List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS) that have published monographs. According to the in loco results, in the city of Campo Grande - MS, plant drugs from medicinal and herbal plants are freely traded on the streets and markets of that city without identification, proper labeling and dosages. On the streets of the city of Campo Grande - MS, as well as on the internet, medicinal plants are sold with packaging claiming the cure process for various diseases, that is, they do not follow the regulations established by Anvisa. It was found that the quantification of heavy metals has been performed in some medicinal plants listed in RENISUS, as well as other species, however, this information is not considered in the monographs. Macro and microelement analyzes must also be carried out on plant drugs to be commercialized. New updates are needed in relation to the list of medicinal plants in RENISUS, which can significantly contribute to avoiding possible health risks for users and informing sellers of medicinal plants of possible dosages. Given the evidence, it is necessary that several countries improve their inspection and monitoring of heavy metals involving medicinal plants in the form of drugs and plant derivatives, in order to mitigate the vulnerability of the population that consumes these products. In addition, it is necessary to develop monographs of medicinal plants with the inclusion of information regarding the quantification of heavy metals and risk calculations, and comparison of the intake limits for heavy metals established by regulatory agencies.A utilização de plantas medicinais tem aumentado nos últimos anos em vários países. Entretanto, o consumo indiscriminado de plantas medicinais oferece riscos à saúde devido a vários fatores como a ingestão de plantas identificadas incorretamente, overdose, longa duração da administração, combinação inadequada de plantas e contaminação por microrganismos e metais pesados. Políticas públicas têm sido criadas em vários países com o intuito de valorizar e fornecer segurança ao consumidor, assim como regulamentos têm sido estabelecidos. Diante do exposto, esta dissertação tem como objetivo: a) descrever as regulamentações relativas ao registro e notificação de drogas vegetais, medicamentos fitoterápicos e produtos tradicionais fitoterápicos, com ênfase na quantificação de metais pesados; b) realizar um estudo in loco para verificação do cumprimento da normativa quanto à identificação, rotulagem e dosagem de drogas vegetais comercializadas em Campo Grande - MS; e c) Descrever estudos de quantificação de metais pesados em plantas medicinais compreendidas na Relação de Plantas Medicinais de Interesse ao Sistema Único de Saúde Brasileiro (RENISUS) que possuem monografias publicadas. De acordo com os resultados in loco, na Cidade de Campo Grande - MS, as drogas vegetais provenientes de plantas medicinais e fitoterápicos são comercializadas livremente nas ruas e mercados dessa cidade sem identificação, rotulagem adequada e dosagens. Nas ruas da cidade de Campo Grande - MS, assim como na internet, plantas medicinais são comercializadas com embalagens alegando o processo de cura para várias doenças, ou seja, não seguem as normativas estabelecidas pela Anvisa. Constatou-se que as plantas medicinais contidas na RENISUS, assim como várias espécies têm sido avaliadas quanto ao conteúdo de metais pesados, porém, essas informações não são consideradas nas monografias. Análises de macro e microelementos devem ser realizadas também em drogas vegetais para serem comercializadas. Novas atualizações são necessárias em relação à lista de plantas medicinas do RENISUS, o que pode contribuir significativamente para evitar possíveis riscos à saúde de usuários e informar os vendedores de plantas medicinais das possíveis dosagens. Diante das evidencias, é necessário que vários países aperfeiçoem sua fiscalização e monitoramento de metais pesados envolvendo as plantas medicinais sob a forma de drogas e derivados vegetais, com o intuito de mitigar a vulnerabilidade da população que consome esses produtos procurando benefícios à saúde com base na fitoterapia, além disso, é necessário o desenvolvimento de monografias das plantas medicinais com a inclusão das informações relativas à quantificação de metais, com a comparação dos limites de ingestão estabelecidos pelos órgãos responsáveis e cálculos de risco de ingestão quando existentes.Fundação Universidade Federal de Mato Grosso do SulUFMSBrasilplantas medicinaisfitoterápicosmonografiasRENISUSAnvisa.O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisNascimento, Valter Aragão doAdemir da Silva Alves Juniorinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UFMSinstname:Universidade Federal de Mato Grosso do Sul (UFMS)instacron:UFMSTHUMBNAILDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdf.jpgDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdf.jpgGenerated Thumbnailimage/jpeg1194https://repositorio.ufms.br/bitstream/123456789/4238/3/DISSERTA%c3%87%c3%83O%20-%20ADEMIR%20DA%20SILVA%20ALVES%20JUNIOR.pdf.jpgde3917c7e7b34419e08526430abf399eMD53TEXTDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdf.txtDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdf.txtExtracted texttext/plain193665https://repositorio.ufms.br/bitstream/123456789/4238/2/DISSERTA%c3%87%c3%83O%20-%20ADEMIR%20DA%20SILVA%20ALVES%20JUNIOR.pdf.txt97432d2265db8caa968b7af2628f822fMD52ORIGINALDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdfDISSERTAÇÃO - ADEMIR DA SILVA ALVES JUNIOR.pdfapplication/pdf2914041https://repositorio.ufms.br/bitstream/123456789/4238/1/DISSERTA%c3%87%c3%83O%20-%20ADEMIR%20DA%20SILVA%20ALVES%20JUNIOR.pdf574cab24666e3ce215a73b94ab27ae5dMD51123456789/42382023-03-31 11:30:24.818oai:repositorio.ufms.br:123456789/4238Repositório InstitucionalPUBhttps://repositorio.ufms.br/oai/requestri.prograd@ufms.bropendoar:21242023-03-31T15:30:24Repositório Institucional da UFMS - Universidade Federal de Mato Grosso do Sul (UFMS)false |
dc.title.pt_BR.fl_str_mv |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
title |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
spellingShingle |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS Ademir da Silva Alves Junior plantas medicinais fitoterápicos monografias RENISUS Anvisa. |
title_short |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
title_full |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
title_fullStr |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
title_full_unstemmed |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
title_sort |
O MERCADO INFORMAL DE PLANTAS MEDICINAIS E PRODUTOS FITOTERÁPICOS REGULAMENTADOS NO BRASIL: RISCO DE TOXICIDADE POR METAIS PESADOS |
author |
Ademir da Silva Alves Junior |
author_facet |
Ademir da Silva Alves Junior |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nascimento, Valter Aragão do |
dc.contributor.author.fl_str_mv |
Ademir da Silva Alves Junior |
contributor_str_mv |
Nascimento, Valter Aragão do |
dc.subject.por.fl_str_mv |
plantas medicinais fitoterápicos monografias RENISUS Anvisa. |
topic |
plantas medicinais fitoterápicos monografias RENISUS Anvisa. |
description |
In recent years, the use of medicinal plants has increased in several countries. However, the indiscriminate consumption of medicinal plants poses health risks due to several factors such as ingestion of incorrectly identified plants, overdose, long duration of administration, inadequate combination of plants, as well as contamination by microorganisms and heavy metals. Public policies and regulations have been created in several countries with the aim of valuing and providing safety to the consumer of medicinal plants. Given the above, this dissertation aims to: a) describe the regulations related to the registration and notification of plant drugs, herbal medicines and traditional herbal products, with an emphasis on the quantification of heavy metals; b) carry out an on-site study to verify compliance with regulations regarding the identification, labeling and dosage of plant drugs sold in Campo Grande - MS; and c) investigate the existence of studies on the quantification of heavy metals in medicinal plants listed in the List of Medicinal Plants of Interest to the Brazilian Unified Health System (RENISUS) that have published monographs. According to the in loco results, in the city of Campo Grande - MS, plant drugs from medicinal and herbal plants are freely traded on the streets and markets of that city without identification, proper labeling and dosages. On the streets of the city of Campo Grande - MS, as well as on the internet, medicinal plants are sold with packaging claiming the cure process for various diseases, that is, they do not follow the regulations established by Anvisa. It was found that the quantification of heavy metals has been performed in some medicinal plants listed in RENISUS, as well as other species, however, this information is not considered in the monographs. Macro and microelement analyzes must also be carried out on plant drugs to be commercialized. New updates are needed in relation to the list of medicinal plants in RENISUS, which can significantly contribute to avoiding possible health risks for users and informing sellers of medicinal plants of possible dosages. Given the evidence, it is necessary that several countries improve their inspection and monitoring of heavy metals involving medicinal plants in the form of drugs and plant derivatives, in order to mitigate the vulnerability of the population that consumes these products. In addition, it is necessary to develop monographs of medicinal plants with the inclusion of information regarding the quantification of heavy metals and risk calculations, and comparison of the intake limits for heavy metals established by regulatory agencies. |
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2021 |
dc.date.accessioned.fl_str_mv |
2021-12-23T21:05:19Z |
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2021-12-23T21:05:19Z |
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2021 |
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Fundação Universidade Federal de Mato Grosso do Sul |
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Brasil |
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