Ganho e retenção de peso no pós-parto e na lactação em ratas submetidas à restrição proteica durante a vida intrauterina e a lactação

• Autor(a) principal: Silva, Regiane do Espírito Santo da
• Data de Publicação: 2018
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Biblioteca Digital de Monografias da UFMT
• Texto Completo: http://bdm.ufmt.br/handle/1/686
• topic: CNPQ::CIENCIAS DA SAUDE::NUTRICAO; Prenhez; Pós parto; Retenção de peso; Pregnancy; Postpartum; Weight retention

Obesity is a worldwide public health problem due to its high and increasing prevalence. Several studies have shown an association between birth and childhood weight and obesity in adulthood. It is known that birth and childhood weight depend on maternal nutrition. Gestation and the first few months after childbirth have also been considered risky moments in a woman's life, due to exposure to risks for the development of obesity, including postpartum weight retention. Thus, the present study aimed to evaluate if protein restriction during intrauterine life and lactation contributes to weight gain and retention in postpartum and lactation. Three groups of rats were evaluated: Control Pregnant Group1 (CP1): offspring born and breastfed by mothers fed a normoprotein diet (17% protein) and maintained on the same diet from weaning to lactation. Hippoprotein Pregnant Group1 (HPP1): offspring born and breastfed by mothers fed a hypoprotein diet (6% protein) and maintained on the same diet from weaning to lactation. Retrieved Pregnant Group1 (PR1): Progeny of mothers fed a hypoprotein diet during pregnancy and lactation, who were fed a normoprideic diet from weaning to lactation. Body weight, partial length, BMI, and serum albumin concentration at burn were similar in all three groups. At weaning, body weight, partial length, BMI, glycemia and albuminemia were similar in the groups submitted to protein restriction during lactation, these groups had lower somatic and biochemical parameters than the group maintained on a normoprotein diet. At 90 days of age, the recovered and hypoproteic groups had mean body weights 27% and 62% lower than the control group rats, respectively. The weight gain rate of the recovered group was significantly higher than the other groups at all times. The hypoproteic group presented a similar weight gain rate to the control group only in the first two weeks, being later the rate significantly higher in the first group in relation to the second group. During pregnancy, food intake was higher in the RP1 group than in the CP1 and HPP1 groups. The weight gain did not differ between groups, but the final weight of the RP1 group was higher in relation to the HPP1 group, but lower in comparison to the CP1 group. Postpartum weight balancing and food consumption during lactation were similar in the RP1 and CP1 groups, being these variables higher in these groups in relation to the HPP1 group. In the lactation, the groups RP1 and HPP1 presented similar weight variation, being this variable significantly different in relation to the group CP1. The RP1 and HPP1 groups gained weight, while the CP1 group presented weight loss during lactation. However, the RP1 and HPP1 groups had lower body weights at the end of lactation than the CP1 group. Thus, protein restriction during critical periods of development contributed to weight retention in lactation, but not enough to promote obesity.