Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Monografias da UFMT |
Texto Completo: | http://bdm.ufmt.br/handle/1/3615 |
Resumo: | The use of medicinal plants is widespread among the population. However, many plants may have toxic effect, teratogenic and abortive potential when consumed during pregnancy, as some active ingredients can cross the placental membrane and reaching the fetus. One of these plants without scientific proof of it is toxicity and effectiveness during pregnancy is Buchenavia tomentosa, popularly known as mirindiba. Therefore, this study aimed to evaluate the fetal repercussions of treatment with the aqueous extract of B. tomentosa fruit in pregnant rats. For this, Wistar rats were mated and randomly distributed into four experimental groups (n=12 rats/group): Control Group - Pregnant rats treated with water; Treated Group 125 - Pregnant rats treated with B. tomentosa at a dose of 125 mg/kg; Treated Group 250 - Pregnant rats treated with B. tomentosa at a dose of 250 mg/Kg and Treated Group 500 - Pregnant rats treated with B. tomentosa at a dose of 500 mg/Kg. Treatment with the aqueous extract of the fruit was carried out throughout the pregnancy (days 0 to 21), intragastrically. On the 21st day of pregnancy, a laparotomy was performed and the fetuses and their respective placentas were immediately removed and weighed, for subsequent analysis of external and internal anomalies (visceral and skeletal). The results showed that there were no changes in fetal weight, fetal classification and placental weight between the groups evaluated. Placental efficiency decreased in the Treated 125 and 250 groups compared to the Control group. The Treated 250 and 500 groups increased the incidence of skeletal anomalies, and all treated groups showed an increase in visceral anomalies compared to the Control group. In conclusion, the results indicate that treatment with the aqueous extract of Buchenavia tomentosa fruit during pregnancy can be considered teratogenic, damaging the skeletal and visceral development of the offspring, indicating that the plant's fruit should be avoided during pregnancy. |
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Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratasCNPQ::CIENCIAS DA SAUDE::ENFERMAGEMPlantas medicinaismirindibaprenhezanomaliasMedicinal plantsmirindibapregnancyanomaliesThe use of medicinal plants is widespread among the population. However, many plants may have toxic effect, teratogenic and abortive potential when consumed during pregnancy, as some active ingredients can cross the placental membrane and reaching the fetus. One of these plants without scientific proof of it is toxicity and effectiveness during pregnancy is Buchenavia tomentosa, popularly known as mirindiba. Therefore, this study aimed to evaluate the fetal repercussions of treatment with the aqueous extract of B. tomentosa fruit in pregnant rats. For this, Wistar rats were mated and randomly distributed into four experimental groups (n=12 rats/group): Control Group - Pregnant rats treated with water; Treated Group 125 - Pregnant rats treated with B. tomentosa at a dose of 125 mg/kg; Treated Group 250 - Pregnant rats treated with B. tomentosa at a dose of 250 mg/Kg and Treated Group 500 - Pregnant rats treated with B. tomentosa at a dose of 500 mg/Kg. Treatment with the aqueous extract of the fruit was carried out throughout the pregnancy (days 0 to 21), intragastrically. On the 21st day of pregnancy, a laparotomy was performed and the fetuses and their respective placentas were immediately removed and weighed, for subsequent analysis of external and internal anomalies (visceral and skeletal). The results showed that there were no changes in fetal weight, fetal classification and placental weight between the groups evaluated. Placental efficiency decreased in the Treated 125 and 250 groups compared to the Control group. The Treated 250 and 500 groups increased the incidence of skeletal anomalies, and all treated groups showed an increase in visceral anomalies compared to the Control group. In conclusion, the results indicate that treatment with the aqueous extract of Buchenavia tomentosa fruit during pregnancy can be considered teratogenic, damaging the skeletal and visceral development of the offspring, indicating that the plant's fruit should be avoided during pregnancy.A utilização de plantas medicinais é bastante disseminada na população. No entanto, muitas plantas podem apresentar potencial tóxico, teratogênico e abortivo quando consumidas na gestação, pois alguns principios ativos são capazes de atravessar a membrana placentárna e atingir o feto. Uma dessas plantas sem comprovação científica da sua toxicidade e eficácia no periodo gestacional é a Buchenavia tomentosa, popularmente conhecida como mirindiba. Desta maneira, este estudo objetivou avaliar as repercussões fetais do tratamento do extrato aquoso da fruta de B. tomentosa na prenhez de ratas. Para isso, ratas Wistar foram acasaladas e distribuidas aleatoriamente em quatro grupos experimentais (n=12 ratas/grupo) Grupo Controle - Ratas prenhes tratadas com água; Grupo Tratado 125 - Ratas prenhes tratadas com a tomentosa na dose de 125 mg/Kg: Grupo Tratado 250- Ratas prenhes tratadas com B. tomentosa na dose de 250 mg/Kg e Grupo Tratado 500-Ratas prenhes tratadas com B. tomentosa na dose de 500 mg/Kg. O tratamento com o extrato aquoso da fruta foi realizado durante toda a prenhez (dia 0 ao 21), por via intragástrica. No dia 21 de prenhez, foi feito a laparotomia e os fetos e suas respectivas placentas foram imediatamente retirados e pesados, para posterior análise de anomalias externas e internas (visceral e esquelética). Os resultados mostraram que não houve alterações no peso letal, na classificação fetal e no peso placentário entre os grupos avaliados. A eficiência placentána diminuiu nos grupos Tratado 125 e 250 comparado ao grupo Controle. Os grupos Tratado 250 e 500 aumentou a incidência de anomalias esqueléticas, e todos os grupos tratados mostraram aumento nas anomalias viscerais em relação ao grupo Controle. Em conclusão, os resultados indicam que o tratamento com o extrato aquoso da fruta de Buchenavia tomentosa na gestação pode ser considerado teratogênico prejudicando a desenvolvimento esquelético e visceral da prole, indicando que a fruta da planta deve ser evitada na prenhez.Universidade Federal de Mato GrossoBrasilInstituto de Ciências Exatas e da Terra (ICET) – AraguaiaUFMT CUA - AraguaiaCiência da Computação - CUASouza, Rafaianne Queiroz de Moraes7377024454258259http://lattes.cnpq.br/7377024454258259Souza, Rafaianne Queiroz de Moraes7377024454258259http://lattes.cnpq.br/7377024454258259Santos, Tainara de Paula Peixoto2619507334702847http://lattes.cnpq.br/2619507334702847Campos, Kleber Eduardo de6939343303863367http://lattes.cnpq.br/6939343303863367Araujo, Alliny Alves de2023-11-21T15:26:09Z2023-10-032023-11-21T15:26:09Z2023-08-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/datasetARAUJO, Alliny Alves de. Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas. 2023. 44 f. Monografia (Bacharelado em Enfermagem) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, 2023.http://bdm.ufmt.br/handle/1/3615porinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Monografias da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2023-11-28T06:04:38Zoai:localhost:1/3615Biblioteca Digital de Monografiahttps://bdm.ufmt.br/PUBhttp://200.129.241.122/oai/requestopendoar:2023-11-28T06:04:38falseBiblioteca Digital de Monografiahttps://bdm.ufmt.br/PUBhttp://200.129.241.122/oai/requestbibliotecacentral@ufmt.br||opendoar:2023-11-28T06:04:38Biblioteca Digital de Monografias da UFMT - Universidade Federal de Mato Grosso (UFMT)false |
dc.title.none.fl_str_mv |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
title |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
spellingShingle |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas Araujo, Alliny Alves de CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM Plantas medicinais mirindiba prenhez anomalias Medicinal plants mirindiba pregnancy anomalies |
title_short |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
title_full |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
title_fullStr |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
title_full_unstemmed |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
title_sort |
Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas |
author |
Araujo, Alliny Alves de |
author_facet |
Araujo, Alliny Alves de |
author_role |
author |
dc.contributor.none.fl_str_mv |
Souza, Rafaianne Queiroz de Moraes 7377024454258259 http://lattes.cnpq.br/7377024454258259 Souza, Rafaianne Queiroz de Moraes 7377024454258259 http://lattes.cnpq.br/7377024454258259 Santos, Tainara de Paula Peixoto 2619507334702847 http://lattes.cnpq.br/2619507334702847 Campos, Kleber Eduardo de 6939343303863367 http://lattes.cnpq.br/6939343303863367 |
dc.contributor.author.fl_str_mv |
Araujo, Alliny Alves de |
dc.subject.por.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM Plantas medicinais mirindiba prenhez anomalias Medicinal plants mirindiba pregnancy anomalies |
topic |
CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM Plantas medicinais mirindiba prenhez anomalias Medicinal plants mirindiba pregnancy anomalies |
description |
The use of medicinal plants is widespread among the population. However, many plants may have toxic effect, teratogenic and abortive potential when consumed during pregnancy, as some active ingredients can cross the placental membrane and reaching the fetus. One of these plants without scientific proof of it is toxicity and effectiveness during pregnancy is Buchenavia tomentosa, popularly known as mirindiba. Therefore, this study aimed to evaluate the fetal repercussions of treatment with the aqueous extract of B. tomentosa fruit in pregnant rats. For this, Wistar rats were mated and randomly distributed into four experimental groups (n=12 rats/group): Control Group - Pregnant rats treated with water; Treated Group 125 - Pregnant rats treated with B. tomentosa at a dose of 125 mg/kg; Treated Group 250 - Pregnant rats treated with B. tomentosa at a dose of 250 mg/Kg and Treated Group 500 - Pregnant rats treated with B. tomentosa at a dose of 500 mg/Kg. Treatment with the aqueous extract of the fruit was carried out throughout the pregnancy (days 0 to 21), intragastrically. On the 21st day of pregnancy, a laparotomy was performed and the fetuses and their respective placentas were immediately removed and weighed, for subsequent analysis of external and internal anomalies (visceral and skeletal). The results showed that there were no changes in fetal weight, fetal classification and placental weight between the groups evaluated. Placental efficiency decreased in the Treated 125 and 250 groups compared to the Control group. The Treated 250 and 500 groups increased the incidence of skeletal anomalies, and all treated groups showed an increase in visceral anomalies compared to the Control group. In conclusion, the results indicate that treatment with the aqueous extract of Buchenavia tomentosa fruit during pregnancy can be considered teratogenic, damaging the skeletal and visceral development of the offspring, indicating that the plant's fruit should be avoided during pregnancy. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-21T15:26:09Z 2023-10-03 2023-11-21T15:26:09Z 2023-08-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/dataset |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ARAUJO, Alliny Alves de. Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas. 2023. 44 f. Monografia (Bacharelado em Enfermagem) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, 2023. http://bdm.ufmt.br/handle/1/3615 |
identifier_str_mv |
ARAUJO, Alliny Alves de. Repercussões fetais do tratamento com Buchenavia tomentosa durante a prenhez de ratas. 2023. 44 f. Monografia (Bacharelado em Enfermagem) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso, Barra do Garças, 2023. |
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http://bdm.ufmt.br/handle/1/3615 |
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por |
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por |
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openAccess |
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Universidade Federal de Mato Grosso Brasil Instituto de Ciências Exatas e da Terra (ICET) – Araguaia UFMT CUA - Araguaia Ciência da Computação - CUA |
publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Instituto de Ciências Exatas e da Terra (ICET) – Araguaia UFMT CUA - Araguaia Ciência da Computação - CUA |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Monografias da UFMT instname:Universidade Federal de Mato Grosso (UFMT) instacron:UFMT |
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Universidade Federal de Mato Grosso (UFMT) |
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UFMT |
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Biblioteca Digital de Monografias da UFMT |
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Biblioteca Digital de Monografias da UFMT |
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Biblioteca Digital de Monografias da UFMT - Universidade Federal de Mato Grosso (UFMT) |
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