Avaliação do conhecimento de acadêmicos e profissionais bioquímicos sobre anomalia de Pelger-Huët

• Autor(a) principal: Sousa, Rute Gabriele Pavan de
• Data de Publicação: 2023
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Biblioteca Digital de Monografias da UFMT
• Texto Completo: http://bdm.ufmt.br/handle/1/3395
• topic: CNPQ::OUTROS::BIOMEDICINA; Pelger-Huët Anomalia; Granulócitos; Diagnóstico; Autossômico Dominante; Heterozigoto; Homozigoto; Pelger-Huët anomaly; Granulocytes; Diagnosis; Autosomal Dominant; Heterozygote; Homozygote

The pelger-hut abnormality is an autosomal dominant disorder characterized by inadequate granulocyte nucleus segmentation without loss of cellular function. The heterozygous variant is asymptomatic, whereas the homozygous type is rare and can be fatal, making it vital to distinguish it from other viral alterations. The objective was to use an electronic questionnaire to assess the knowledge of biochemical and academic experts from biomedicine and pharmacy courses on the Pelger-Hüet anomaly. There were 21 academic researchers, the majority of whom were female, and 29 professionals, the most of whom were also female. The hypossegy of the neutrophil nucleus was known to 32 of the research participants, while only two of the 21 academics were aware of the oddity. However, only ten professionals were aware of Pelger-Hüet. Based on the findings, it is possible to conclude that there is a lack of knowledge about the anomaly, which may lead to diagnostic errors with negative consequences for the patient's health. It is critical that the disciplines of Biomedicine and Pharmacy courses include information on the Pelger-Hüet anomaly to avoid future problems in laboratory routines.