Avaliação dos hidróxidos duplos lamelares na capacidade de amorfização do carvedilol

• Autor(a) principal: Ferreira, Iane de Lima
• Data de Publicação: 2022
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Biblioteca Digital de Monografias da UFMT
• Texto Completo: http://bdm.ufmt.br/handle/1/2485
• topic: CNPQ::CIENCIAS DA SAUDE::FARMACIA; Incorporação; Carvedilol; Matriz de hidróxido duplo lamelar; Caracterizações; Incorporation; Carvedilol; Double Lamellar Hydroxide Matrix; Characterizations

The HDL lamellar double hydroxide matrix has the ability to adsorb, visualize and neutralize between its charges. It is naturally occurring and can be synthesized in the laboratory by simple and low-cost routes. The work comes with the objective of synthesizing, incorporates with a drug and characterizes this matrix and this forming compound. HDL was synthesized in the laboratory from Mg and Al ions by evaporation route and characterized by ray-x diffraction (XRD). Incorporation was done by the dilution and maceration/physical method for comparison purposes. The composites formed were characterized, differential scanning calorimetry (DSC), Fourier Infrared Transformation Spectroscopy (FTIR). Carvedilol (CAR) beta-hypertensive class is an anti-hypertensive factor, being an anti-hypertensive classification system, being a factor of low solubility and high permeability, with the systems being classified as the limiting factor II. MgAl-HDL was incorporated into carvedilol in the following proportions 1:1, 1:2, 1:3, 1:4, 1:5. The FTIR spectrum shows that in all the preparations there is no dilution method as for the maceration method it hears the formation of the CAR/MgAlHDL composite, the DSC shows that no diluted drug system is amorphous, while in the macerated system or drug continues with the melting peak indicating its crystallinity, this indicates that the absorption of CAR by the matrix was in the amorphous form by the diluted system and in the crystalline form in the macerated system. The peak of the system macerated by its intensity, which shows us that the proportion increases, which shows us how the configuration will increase the curvature, concentrating on the most concentrated form. This change in definition is indicative of an improvement in solubility and consequently in its bioavailability.