Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase

Detalhes bibliográficos
Autor(a) principal: Gomes, Luciane Cardoso
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFMT
Texto Completo: http://ri.ufmt.br/handle/1/2783
Resumo: leprosy in people under 15 years of age indicates an early exposure to the causative agent of the disease. It is a high-potential disabling disorder that has been considered hyperendemic in the state of Mato Grosso. Contacts of patients diagnosed with leprosy constitute a high-risk population for infection and disease. Anti-NDO-LID and anti- PGL-I serological tests are ancillary tools for detecting individuals with the infection and at a higher risk of developing the disease. Objective: to analyze the Mycobacterium leprae infection in people under 15 years of age, contacts of leprosy cases, through anti-NID-LID and anti-PGL-I serological tests, in the city of Cuiabá-MT, from 2014 to 2016. Method: this is a cross-sectional study with 250 people under 15 years of age, where 50 were household contacts, 160 were neighborhood contacts and 40 were case-contacts. The information was obtained through notification/investigation records of the disorder, the Information System for Notifiable Diseases in Mato Grosso, interviews by means of a standardized instrument and collection of blood samples, from February to July 2016. In order to analyze data, we employed the following tests: Prevalence Ratio, Kolmogorov-Smirnov, Kruskal-Wallis one- way ANOVA, Spearman correlation coefficient and Poisson and Quantile regressions. Results: among the 250 individuals, 127 (50.8%) were male and 123 (49.2%) were female, with a mean age of 8.3 years. The proportion of anti-NDO-LID positivity in neighborhood contacts was 6.9%; in household contacts, it was 4%; and in contact-cases, it corresponded to 7.5%. The general prevalence of infection in the household and neighborhood contacts was 6.2% with anti-NDO-LID and 2.8% with anti-PGL-I. The western region of the city of Cuiabá showed a higher proportion of seropositivity in the household and neighborhood contacts, while the rural region showed a higher rate of detection of leprosy cases in the child population from 2014 to 2015. We detected a percentage of 1.9% of new cases among the 210 household and neighborhood contacts. As for the factors associated with the seropositivity of the anti-NDO-LID test in neighborhood contacts, we found the variables “race/color” and “number of people in the residence”. We found a positive correlation between the titration of anti-PGL-I antibodies and the variables “number of people aged less than 15 years in the residence” and “overnight time in the same house of a person with leprosy”. The serological tests used in the study showed a reasonable agreement among themselves. Conclusion: the rapid anti-NDO-LID test was more suitable for detecting infection in the investigated population, when compared to the anti-PGL-I. We found a higher percentage of contacts infected in the western region. The accomplishment of a screening with employment of clinical evaluation and serological tests has proved to be a useful strategy to control leprosy. The factors associated with the positive result of the rapid test and the variables correlated with the titration of anti-PGL-I antibodies are linked to sociodemographic and co-housing aspects.
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spelling Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de HanseníaseHanseníaseTestes sorológicosNDO-LIDPGL-ICriançaAdolescenteCNPQ::CIENCIAS DA SAUDE::ENFERMAGEMLeprosySerological testsNDO-LIDPGL-IChildAdolescentleprosy in people under 15 years of age indicates an early exposure to the causative agent of the disease. It is a high-potential disabling disorder that has been considered hyperendemic in the state of Mato Grosso. Contacts of patients diagnosed with leprosy constitute a high-risk population for infection and disease. Anti-NDO-LID and anti- PGL-I serological tests are ancillary tools for detecting individuals with the infection and at a higher risk of developing the disease. Objective: to analyze the Mycobacterium leprae infection in people under 15 years of age, contacts of leprosy cases, through anti-NID-LID and anti-PGL-I serological tests, in the city of Cuiabá-MT, from 2014 to 2016. Method: this is a cross-sectional study with 250 people under 15 years of age, where 50 were household contacts, 160 were neighborhood contacts and 40 were case-contacts. The information was obtained through notification/investigation records of the disorder, the Information System for Notifiable Diseases in Mato Grosso, interviews by means of a standardized instrument and collection of blood samples, from February to July 2016. In order to analyze data, we employed the following tests: Prevalence Ratio, Kolmogorov-Smirnov, Kruskal-Wallis one- way ANOVA, Spearman correlation coefficient and Poisson and Quantile regressions. Results: among the 250 individuals, 127 (50.8%) were male and 123 (49.2%) were female, with a mean age of 8.3 years. The proportion of anti-NDO-LID positivity in neighborhood contacts was 6.9%; in household contacts, it was 4%; and in contact-cases, it corresponded to 7.5%. The general prevalence of infection in the household and neighborhood contacts was 6.2% with anti-NDO-LID and 2.8% with anti-PGL-I. The western region of the city of Cuiabá showed a higher proportion of seropositivity in the household and neighborhood contacts, while the rural region showed a higher rate of detection of leprosy cases in the child population from 2014 to 2015. We detected a percentage of 1.9% of new cases among the 210 household and neighborhood contacts. As for the factors associated with the seropositivity of the anti-NDO-LID test in neighborhood contacts, we found the variables “race/color” and “number of people in the residence”. We found a positive correlation between the titration of anti-PGL-I antibodies and the variables “number of people aged less than 15 years in the residence” and “overnight time in the same house of a person with leprosy”. The serological tests used in the study showed a reasonable agreement among themselves. Conclusion: the rapid anti-NDO-LID test was more suitable for detecting infection in the investigated population, when compared to the anti-PGL-I. We found a higher percentage of contacts infected in the western region. The accomplishment of a screening with employment of clinical evaluation and serological tests has proved to be a useful strategy to control leprosy. The factors associated with the positive result of the rapid test and the variables correlated with the titration of anti-PGL-I antibodies are linked to sociodemographic and co-housing aspects.a hanseníase em menores de 15 anos indica exposição precoce ao agente causador da doença. Trata-se de um agravo de alto potencial incapacitante que tem sido considerado hiperendêmico no estado de Mato Grosso. Contatos de pacientes diagnosticados com hanseníase constituem população de alto risco para a infecção e doença. Os testes sorológicos anti-NDO-LID e anti-PGL-I consistem em ferramentas auxiliares para a detecção de indivíduos com a infecção e em maior risco de desenvolver a doença. Objetivo: analisar a infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de hanseníase por meio dos testes sorológicos anti-NDO-LID e anti-PGL-I, no município de Cuiabá-MT, no período de 2014 a 2016. Método: estudo transversal com 250 menores de 15 anos, sendo 50 contatos domiciliares, 160 contatos de vizinhança e 40 contatos-casos. As informações foram obtidas por fichas de notificação/investigação do agravo, do Sistema de Informação de Agravos de Notificação de Mato Grosso, entrevistas por meio de instrumento padronizado e coleta de amostras de sangue, no período de fevereiro a julho de 2016. Para análise, empregou-se os seguintes testes: Razão de Prevalência, Kolmogorov-Smirnov, Kruskal- Wallis one-way ANOVA, coeficiente de correlação de Spearman e regressões de Poisson e Quantílica. Resultados: dentre os 250 indivíduos, 127 (50,8%) eram do sexo masculino e 123 (49,2%) feminino, com idade média de 8,3 anos. A proporção de positividade de anti-NDO- LID em contatos de vizinhança foi de 6,9%, em contatos domiciliares de 4% e em contatos- casos correspondeu a 7,5%. A prevalência geral de infecção em contatos domiciliares e vizinhança foi de 6,2 % com anti-NDO-LID e de 2,8 % com anti-PGL-I. A região Oeste do município de Cuiabá apresentou maior proporção de soropositividade em contatos domiciliares e de vizinhança, enquanto a região rural apresentou maior taxa de detecção de casos de hanseníase na população infantil no período de 2014 a 2015. Detectou-se 1,9% de casos novos dentre os 210 contatos domiciliares e de vizinhança. Verificou-se como fatores associados à soropositividade do teste anti-NDO-LID em contatos de vizinhança, as variáveis “raça/cor” e “número de pessoas na residência”. Observou-se correlação positiva entre a titulação de anticorpos anti-PGL-I e as variáveis “número de menores de 15 anos na residência” e “tempo em que dormiu na mesma casa de pessoa com hanseníase”. Os testes sorológicos utilizados no estudo apresentaram, entre si, concordância razoável. Conclusão: o teste rápido anti-NDO-LID foi mais adequado para a detecção de infecção na população investigada, quando comparado ao anti-PGL-I. Constatou-se maior percentual de contatos infectados na região Oeste. A realização de rastreamento com emprego de avaliação clínica e testes sorológicos mostrou-se estratégia útil para controle da hanseníase. Os fatores associados ao resultado positivo do teste rápido e as variáveis correlacionadas à titulação de anticorpos anti-PGL-I estão ligados a aspectos sociodemográficos e co-habitacionais.Universidade Federal de Mato GrossoBrasilFaculdade de Enfermagem (FAEN)UFMT CUC - CuiabáPrograma de Pós-Graduação em EnfermagemFerreira, Silvana Margarida Benevideshttp://lattes.cnpq.br/8502773887053597Ferreira, Silvana Margarida Benevides275.095.241-72http://lattes.cnpq.br/8502773887053597Marcon, Samira Reschetti545.264.001-06http://lattes.cnpq.br/0420806346592571275.095.241-72Cortela, Denise da Costa Boamorte068.011.718-01http://lattes.cnpq.br/6159788199115008Silva, Ageo Mário Cândido da496.166.099-04http://lattes.cnpq.br/0860844016463817Silva, Eliane Aparecida983.078.358-87http://lattes.cnpq.br/1025452284973109Gomes, Luciane Cardoso2021-08-18T11:48:25Z2017-02-062021-08-18T11:48:25Z2016-12-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisGOMES, Luciane Cardoso. Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase. 2016. 113 f. Dissertação (Mestrado em Enfermagem) - Universidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, 2016.http://ri.ufmt.br/handle/1/2783porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2021-08-20T07:01:43Zoai:localhost:1/2783Repositório InstitucionalPUBhttp://ri.ufmt.br/oai/requestjordanbiblio@gmail.comopendoar:2021-08-20T07:01:43Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)false
dc.title.none.fl_str_mv Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
title Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
spellingShingle Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
Gomes, Luciane Cardoso
Hanseníase
Testes sorológicos
NDO-LID
PGL-I
Criança
Adolescente
CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM
Leprosy
Serological tests
NDO-LID
PGL-I
Child
Adolescent
title_short Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
title_full Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
title_fullStr Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
title_full_unstemmed Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
title_sort Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase
author Gomes, Luciane Cardoso
author_facet Gomes, Luciane Cardoso
author_role author
dc.contributor.none.fl_str_mv Ferreira, Silvana Margarida Benevides
http://lattes.cnpq.br/8502773887053597
Ferreira, Silvana Margarida Benevides
275.095.241-72
http://lattes.cnpq.br/8502773887053597
Marcon, Samira Reschetti
545.264.001-06
http://lattes.cnpq.br/0420806346592571
275.095.241-72
Cortela, Denise da Costa Boamorte
068.011.718-01
http://lattes.cnpq.br/6159788199115008
Silva, Ageo Mário Cândido da
496.166.099-04
http://lattes.cnpq.br/0860844016463817
Silva, Eliane Aparecida
983.078.358-87
http://lattes.cnpq.br/1025452284973109
dc.contributor.author.fl_str_mv Gomes, Luciane Cardoso
dc.subject.por.fl_str_mv Hanseníase
Testes sorológicos
NDO-LID
PGL-I
Criança
Adolescente
CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM
Leprosy
Serological tests
NDO-LID
PGL-I
Child
Adolescent
topic Hanseníase
Testes sorológicos
NDO-LID
PGL-I
Criança
Adolescente
CNPQ::CIENCIAS DA SAUDE::ENFERMAGEM
Leprosy
Serological tests
NDO-LID
PGL-I
Child
Adolescent
description leprosy in people under 15 years of age indicates an early exposure to the causative agent of the disease. It is a high-potential disabling disorder that has been considered hyperendemic in the state of Mato Grosso. Contacts of patients diagnosed with leprosy constitute a high-risk population for infection and disease. Anti-NDO-LID and anti- PGL-I serological tests are ancillary tools for detecting individuals with the infection and at a higher risk of developing the disease. Objective: to analyze the Mycobacterium leprae infection in people under 15 years of age, contacts of leprosy cases, through anti-NID-LID and anti-PGL-I serological tests, in the city of Cuiabá-MT, from 2014 to 2016. Method: this is a cross-sectional study with 250 people under 15 years of age, where 50 were household contacts, 160 were neighborhood contacts and 40 were case-contacts. The information was obtained through notification/investigation records of the disorder, the Information System for Notifiable Diseases in Mato Grosso, interviews by means of a standardized instrument and collection of blood samples, from February to July 2016. In order to analyze data, we employed the following tests: Prevalence Ratio, Kolmogorov-Smirnov, Kruskal-Wallis one- way ANOVA, Spearman correlation coefficient and Poisson and Quantile regressions. Results: among the 250 individuals, 127 (50.8%) were male and 123 (49.2%) were female, with a mean age of 8.3 years. The proportion of anti-NDO-LID positivity in neighborhood contacts was 6.9%; in household contacts, it was 4%; and in contact-cases, it corresponded to 7.5%. The general prevalence of infection in the household and neighborhood contacts was 6.2% with anti-NDO-LID and 2.8% with anti-PGL-I. The western region of the city of Cuiabá showed a higher proportion of seropositivity in the household and neighborhood contacts, while the rural region showed a higher rate of detection of leprosy cases in the child population from 2014 to 2015. We detected a percentage of 1.9% of new cases among the 210 household and neighborhood contacts. As for the factors associated with the seropositivity of the anti-NDO-LID test in neighborhood contacts, we found the variables “race/color” and “number of people in the residence”. We found a positive correlation between the titration of anti-PGL-I antibodies and the variables “number of people aged less than 15 years in the residence” and “overnight time in the same house of a person with leprosy”. The serological tests used in the study showed a reasonable agreement among themselves. Conclusion: the rapid anti-NDO-LID test was more suitable for detecting infection in the investigated population, when compared to the anti-PGL-I. We found a higher percentage of contacts infected in the western region. The accomplishment of a screening with employment of clinical evaluation and serological tests has proved to be a useful strategy to control leprosy. The factors associated with the positive result of the rapid test and the variables correlated with the titration of anti-PGL-I antibodies are linked to sociodemographic and co-housing aspects.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-19
2017-02-06
2021-08-18T11:48:25Z
2021-08-18T11:48:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv GOMES, Luciane Cardoso. Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase. 2016. 113 f. Dissertação (Mestrado em Enfermagem) - Universidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, 2016.
http://ri.ufmt.br/handle/1/2783
identifier_str_mv GOMES, Luciane Cardoso. Infecção por Mycobacterium leprae em menores de 15 anos contatos de casos de Hanseníase. 2016. 113 f. Dissertação (Mestrado em Enfermagem) - Universidade Federal de Mato Grosso, Faculdade de Enfermagem, Cuiabá, 2016.
url http://ri.ufmt.br/handle/1/2783
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Mato Grosso
Brasil
Faculdade de Enfermagem (FAEN)
UFMT CUC - Cuiabá
Programa de Pós-Graduação em Enfermagem
publisher.none.fl_str_mv Universidade Federal de Mato Grosso
Brasil
Faculdade de Enfermagem (FAEN)
UFMT CUC - Cuiabá
Programa de Pós-Graduação em Enfermagem
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMT
instname:Universidade Federal de Mato Grosso (UFMT)
instacron:UFMT
instname_str Universidade Federal de Mato Grosso (UFMT)
instacron_str UFMT
institution UFMT
reponame_str Repositório Institucional da UFMT
collection Repositório Institucional da UFMT
repository.name.fl_str_mv Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)
repository.mail.fl_str_mv jordanbiblio@gmail.com
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