Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna)
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMT |
Texto Completo: | http://ri.ufmt.br/handle/1/1427 |
Resumo: | The Blue and Gold Macaws (Ara ararauna) are classified as great psittacine birds and have a wide distribution in South American countries. The aim of this study was to evaluate the effects of two protocols of total intravenous anesthesia (TIVA) over the cardiovascular, respiratory systems and the recovery time, to establish safe doses and to determine whether S(+)-ketamine is effective for offsetting the side effects of propofol for anesthesia in blue and gold macaws. The analyzed parameters included included heart rate (HR), non-invasive systolic arterial pressure (SAP), respiratory frequency (ƒ), peripheral O2 saturation in hemoglobin (SpO2) , end tidal CO2 (EtCO2), cloacal temperature (CT), corneal reflex (CR) and response to inter-digital pinch (IP). All of these parameter except for CR and IP were analyzed in T0 (with the animals physically restrained). All the other parameters including CR and IP were analyzed in 5 (T5), 10 (T10), 20 (T20) and 30 (30) minutes following the induction of anesthesia. For this, eight blue and gold macaws, adults, healthy to the clinical examination, weighting 1.043±0,1 kg in the propofol group (PG) and 1.011±0,07 kg in the propofol/S(+)-ketamine group (PSKG), were submitted to intravenous (I.V.) induction with 1% propofol administered to the effect. In the PSKG, the mean propofol dose used for induction in the PG was reduced and slowly administrated, sufficiently to obtain a degree of muscle relaxation prior to the I.V. administration of S(+)-ketamine. The S(+)-ketamine was administered in a dose of 1.4 mg.kg-1 and for the administration it was previously diluted with 0.9% saline (0,06 ml of S(+)-ketamine with 1 ml of saline) to become a 0.3% S(+)-ketamine solution. For the continuous rate infusion (CRI) propofol was previously diluted in 0.9% saline (7 ml of propofol with 13 ml of saline) so that its concentration was 0.35% and so was the S(+)-ketamine diluted to reach the concentration of 0.15% (0.6 ml of S(+)-ketamine with 19.4 ml of saline). The maintenance dose in the PG was 1 mg.kg-1min1. In the PSKG, the maintenance doses were 0.15 mg.kg-1min-1 of S(+)-ketamine and 0.5 mg.kg-1min-1 of propofol, 50% less than the maintenance dose from the PG. The mean propofol induction dose (±SD) was 8.1 ± 0.89 mg.kg-1 (PG). In the PSKG, the mean doses were 4.9 ± 1.09 mg.kg-1 of propofol and 1.4 mg.kg-1 of S(+)-ketamine. The cardiovascular system was stable in both groups. In the PG, 62.5% of the macaws required ventilation support due to apnea. The EtCO2 and the SpO2values were higher in the PSKG than in the PG. In conclusion, given that the recovery times did not differ between the groups and cardiovascular stability that was provided, both protocols are safe for anesthetizing blue and gold macaws. Assisted ventilation may be required for both protocols and, S(+)-ketamine reduced the induction and maintenance doses of propofol when compared to propofol alone. |
id |
UFMT_bde111b29a815f7c567cd407a981e702 |
---|---|
oai_identifier_str |
oai:localhost:1/1427 |
network_acronym_str |
UFMT |
network_name_str |
Repositório Institucional da UFMT |
repository_id_str |
|
spelling |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna)AnestesiaAra araraunaAvesCetamina-S(+)PropofolPsitacidaeCNPQ::CIENCIAS HUMANAS::EDUCACAOAnesthesiaAra araraunaAvianPropofoPsittacidaeS(+)-ketamineThe Blue and Gold Macaws (Ara ararauna) are classified as great psittacine birds and have a wide distribution in South American countries. The aim of this study was to evaluate the effects of two protocols of total intravenous anesthesia (TIVA) over the cardiovascular, respiratory systems and the recovery time, to establish safe doses and to determine whether S(+)-ketamine is effective for offsetting the side effects of propofol for anesthesia in blue and gold macaws. The analyzed parameters included included heart rate (HR), non-invasive systolic arterial pressure (SAP), respiratory frequency (ƒ), peripheral O2 saturation in hemoglobin (SpO2) , end tidal CO2 (EtCO2), cloacal temperature (CT), corneal reflex (CR) and response to inter-digital pinch (IP). All of these parameter except for CR and IP were analyzed in T0 (with the animals physically restrained). All the other parameters including CR and IP were analyzed in 5 (T5), 10 (T10), 20 (T20) and 30 (30) minutes following the induction of anesthesia. For this, eight blue and gold macaws, adults, healthy to the clinical examination, weighting 1.043±0,1 kg in the propofol group (PG) and 1.011±0,07 kg in the propofol/S(+)-ketamine group (PSKG), were submitted to intravenous (I.V.) induction with 1% propofol administered to the effect. In the PSKG, the mean propofol dose used for induction in the PG was reduced and slowly administrated, sufficiently to obtain a degree of muscle relaxation prior to the I.V. administration of S(+)-ketamine. The S(+)-ketamine was administered in a dose of 1.4 mg.kg-1 and for the administration it was previously diluted with 0.9% saline (0,06 ml of S(+)-ketamine with 1 ml of saline) to become a 0.3% S(+)-ketamine solution. For the continuous rate infusion (CRI) propofol was previously diluted in 0.9% saline (7 ml of propofol with 13 ml of saline) so that its concentration was 0.35% and so was the S(+)-ketamine diluted to reach the concentration of 0.15% (0.6 ml of S(+)-ketamine with 19.4 ml of saline). The maintenance dose in the PG was 1 mg.kg-1min1. In the PSKG, the maintenance doses were 0.15 mg.kg-1min-1 of S(+)-ketamine and 0.5 mg.kg-1min-1 of propofol, 50% less than the maintenance dose from the PG. The mean propofol induction dose (±SD) was 8.1 ± 0.89 mg.kg-1 (PG). In the PSKG, the mean doses were 4.9 ± 1.09 mg.kg-1 of propofol and 1.4 mg.kg-1 of S(+)-ketamine. The cardiovascular system was stable in both groups. In the PG, 62.5% of the macaws required ventilation support due to apnea. The EtCO2 and the SpO2values were higher in the PSKG than in the PG. In conclusion, given that the recovery times did not differ between the groups and cardiovascular stability that was provided, both protocols are safe for anesthetizing blue and gold macaws. Assisted ventilation may be required for both protocols and, S(+)-ketamine reduced the induction and maintenance doses of propofol when compared to propofol alone.CAPESAs Araras Canindé (Ara ararauna) são classificadas como grandes psitacídeos e tem uma ampla distribuição nos países da América do Sul. O objetivo deste estudo foi avaliar os efeitos de dois protocolos de anestesia intravenosa total (AIT) sob os sistemas cardiovascular, respiratório e tempo de recuperação da anestesia, para estabelecer doses seguras a determinar se a cetamina-S(+) foi capaz de contrabalancear os efeitos colaterais do propofol para anestesia em araras canindé. Os parâmetros avaliados foram frequência cardíaca (FC), pressão arterial sistólica não invasiva (PAS), frequência respiratória (ƒ), saturação periférica de O2 na hemoglobina (SpO2), CO2 no ar expirado (EtCO2), temperatura cloacal (TC), reflexo corneal (RC) e resposta ao pinçamento interdigital (PI). Os mesmos, com exceção de RC e PI, foram aferidos no tempo 0 (T0) (com os animais sob contenção física). Todos os demais parâmetros incluindo RC e PI foram avaliados aos 5 (T5), 10 (T10), 20 (T20) e 30(T30) minutos após a indução da anestesia. Para isso, oito Araras Canindé, adultas, saudáveis ao exame clínico, pesando entre 1,043 ± 0,1 kg no grupo propofol (GP) e 1,011 ± 0,07 kg no grupo propofol/cetamina-S(+) (GPCS), foram submetidas à indução com propofol 1%, administrado ao efeito pela via intravenosa (I.V.). Em GPCS, a dose média de propofol utilizada em GP foi reduzida e administrada lentamente apenas para obtenção de relaxamento muscular antes da aplicação I.V. de cetamina-S(+). A mesma fora administrada na dose de 1,4 mg.kg-1 e para isso, era previamente diluída em solução salina 0,9% (0,06 ml de cetaminaS(+) em 1 ml de solução salina) atingindo a concentração de 0,3%. Para a infusão contínua o propofol era previamente diluído em solução salina 0,9% (7 ml de propofol em 13 ml de solução salina) para atingir a concentração de 0,35% e a cetamina-S(+), da mesma forma, para atingir a concentração de 0,15% (0,6 ml de cetamina-S(+) em 19,4 ml de solução salina). A dose média de indução de propofol em PG foi de 8,1 ± 0,89 mg.kg-1 . Em GPCS as doses médias foram de 4,9 ± 1,09 mg.kg-1 de propofol e 1.4 mg.kg-1 de cetamina-S(+). A dose de manutenção em GP foi de 1mg.kg-1min-1 . Em GPCS, as doses de manutenção foram de 0,15 mg.kg-1min1 de cetamina-S(+) e 0,5 mg.kg-1min-1 de propofol, 50% da dose de manutenção em GP. A dose média de propofol para indução foi de 8,1 ± 0,89 mg.kg-1 para GP e 4,9 ± 1,09 mg.kg-1 para GPCS. O sistema cardiovascular ficou estável em ambos os grupos. Em PG, 62,5% das araras necessitaram de ventilação manual devido à apneia. Os valores de EtCO2 e a SpO2 foram maiores em GPCS que em GP. Concluindo, como os tempos de recuperação anestésica não diferiram (p< 0,05) e dada à estabilidade cardiovascular observada, ambos os protocolos são seguros para anestesia em araras canindé, porém, pode ser necessário suporte ventilatório em ambos os protocolos. Além disso, a cetamina-S(+) combinada ao propofol possibilitou a redução das doses de indução e manutenção de propofol, comparadas ao propofol isoladamente.Universidade Federal de Mato GrossoBrasilFaculdade de Agronomia, Medicina Veterinária e Zootecnia (FAMEVZ)UFMT CUC - CuiabáPrograma de Pós-Graduação em Ciências VeterináriasGuimaraes, Luciana DambrósioConceição, Elaine Dione Venêga dahttp://lattes.cnpq.br/2270006050996462http://lattes.cnpq.br/9316629105349176Guimaraes, Luciana Dambrósio657.964.110-04http://lattes.cnpq.br/9316629105349176Conceição, Elaine Dione Venêga da570.827.821-87http://lattes.cnpq.br/2270006050996462657.964.110-04570.827.821-87Corrêa, Sandra Helena Ramiro826.530.979-15http://lattes.cnpq.br/4158238188832333Oleskovicz, Nilson866.791.209-34http://lattes.cnpq.br/3150288038945608Jorge, Adriano Alves2019-09-12T09:00:28Z2012-04-192019-09-12T09:00:28Z2012-02-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisJORGE, Adriano Alves. Anestesia intravenosa total com propofol ou propofol e cetamina-s(+) em araras canindé (Ara ararauna). 2012. 87 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal de Mato Grosso, Faculdade de Agronomia, Medicina Veterinária e Zootecnia, Cuiabá, 2012.http://ri.ufmt.br/handle/1/1427porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2019-09-16T07:02:29Zoai:localhost:1/1427Repositório InstitucionalPUBhttp://ri.ufmt.br/oai/requestjordanbiblio@gmail.comopendoar:2019-09-16T07:02:29Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)false |
dc.title.none.fl_str_mv |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
title |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
spellingShingle |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) Jorge, Adriano Alves Anestesia Ara ararauna Aves Cetamina-S(+) Propofol Psitacidae CNPQ::CIENCIAS HUMANAS::EDUCACAO Anesthesia Ara ararauna Avian Propofo Psittacidae S(+)-ketamine |
title_short |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
title_full |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
title_fullStr |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
title_full_unstemmed |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
title_sort |
Anestesia intravenosa total com propofol ou propofol e cetamina-S(+) em araras canindé (Ara ararauna) |
author |
Jorge, Adriano Alves |
author_facet |
Jorge, Adriano Alves |
author_role |
author |
dc.contributor.none.fl_str_mv |
Guimaraes, Luciana Dambrósio Conceição, Elaine Dione Venêga da http://lattes.cnpq.br/2270006050996462 http://lattes.cnpq.br/9316629105349176 Guimaraes, Luciana Dambrósio 657.964.110-04 http://lattes.cnpq.br/9316629105349176 Conceição, Elaine Dione Venêga da 570.827.821-87 http://lattes.cnpq.br/2270006050996462 657.964.110-04 570.827.821-87 Corrêa, Sandra Helena Ramiro 826.530.979-15 http://lattes.cnpq.br/4158238188832333 Oleskovicz, Nilson 866.791.209-34 http://lattes.cnpq.br/3150288038945608 |
dc.contributor.author.fl_str_mv |
Jorge, Adriano Alves |
dc.subject.por.fl_str_mv |
Anestesia Ara ararauna Aves Cetamina-S(+) Propofol Psitacidae CNPQ::CIENCIAS HUMANAS::EDUCACAO Anesthesia Ara ararauna Avian Propofo Psittacidae S(+)-ketamine |
topic |
Anestesia Ara ararauna Aves Cetamina-S(+) Propofol Psitacidae CNPQ::CIENCIAS HUMANAS::EDUCACAO Anesthesia Ara ararauna Avian Propofo Psittacidae S(+)-ketamine |
description |
The Blue and Gold Macaws (Ara ararauna) are classified as great psittacine birds and have a wide distribution in South American countries. The aim of this study was to evaluate the effects of two protocols of total intravenous anesthesia (TIVA) over the cardiovascular, respiratory systems and the recovery time, to establish safe doses and to determine whether S(+)-ketamine is effective for offsetting the side effects of propofol for anesthesia in blue and gold macaws. The analyzed parameters included included heart rate (HR), non-invasive systolic arterial pressure (SAP), respiratory frequency (ƒ), peripheral O2 saturation in hemoglobin (SpO2) , end tidal CO2 (EtCO2), cloacal temperature (CT), corneal reflex (CR) and response to inter-digital pinch (IP). All of these parameter except for CR and IP were analyzed in T0 (with the animals physically restrained). All the other parameters including CR and IP were analyzed in 5 (T5), 10 (T10), 20 (T20) and 30 (30) minutes following the induction of anesthesia. For this, eight blue and gold macaws, adults, healthy to the clinical examination, weighting 1.043±0,1 kg in the propofol group (PG) and 1.011±0,07 kg in the propofol/S(+)-ketamine group (PSKG), were submitted to intravenous (I.V.) induction with 1% propofol administered to the effect. In the PSKG, the mean propofol dose used for induction in the PG was reduced and slowly administrated, sufficiently to obtain a degree of muscle relaxation prior to the I.V. administration of S(+)-ketamine. The S(+)-ketamine was administered in a dose of 1.4 mg.kg-1 and for the administration it was previously diluted with 0.9% saline (0,06 ml of S(+)-ketamine with 1 ml of saline) to become a 0.3% S(+)-ketamine solution. For the continuous rate infusion (CRI) propofol was previously diluted in 0.9% saline (7 ml of propofol with 13 ml of saline) so that its concentration was 0.35% and so was the S(+)-ketamine diluted to reach the concentration of 0.15% (0.6 ml of S(+)-ketamine with 19.4 ml of saline). The maintenance dose in the PG was 1 mg.kg-1min1. In the PSKG, the maintenance doses were 0.15 mg.kg-1min-1 of S(+)-ketamine and 0.5 mg.kg-1min-1 of propofol, 50% less than the maintenance dose from the PG. The mean propofol induction dose (±SD) was 8.1 ± 0.89 mg.kg-1 (PG). In the PSKG, the mean doses were 4.9 ± 1.09 mg.kg-1 of propofol and 1.4 mg.kg-1 of S(+)-ketamine. The cardiovascular system was stable in both groups. In the PG, 62.5% of the macaws required ventilation support due to apnea. The EtCO2 and the SpO2values were higher in the PSKG than in the PG. In conclusion, given that the recovery times did not differ between the groups and cardiovascular stability that was provided, both protocols are safe for anesthetizing blue and gold macaws. Assisted ventilation may be required for both protocols and, S(+)-ketamine reduced the induction and maintenance doses of propofol when compared to propofol alone. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-19 2012-02-27 2019-09-12T09:00:28Z 2019-09-12T09:00:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
JORGE, Adriano Alves. Anestesia intravenosa total com propofol ou propofol e cetamina-s(+) em araras canindé (Ara ararauna). 2012. 87 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal de Mato Grosso, Faculdade de Agronomia, Medicina Veterinária e Zootecnia, Cuiabá, 2012. http://ri.ufmt.br/handle/1/1427 |
identifier_str_mv |
JORGE, Adriano Alves. Anestesia intravenosa total com propofol ou propofol e cetamina-s(+) em araras canindé (Ara ararauna). 2012. 87 f. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal de Mato Grosso, Faculdade de Agronomia, Medicina Veterinária e Zootecnia, Cuiabá, 2012. |
url |
http://ri.ufmt.br/handle/1/1427 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Faculdade de Agronomia, Medicina Veterinária e Zootecnia (FAMEVZ) UFMT CUC - Cuiabá Programa de Pós-Graduação em Ciências Veterinárias |
publisher.none.fl_str_mv |
Universidade Federal de Mato Grosso Brasil Faculdade de Agronomia, Medicina Veterinária e Zootecnia (FAMEVZ) UFMT CUC - Cuiabá Programa de Pós-Graduação em Ciências Veterinárias |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMT instname:Universidade Federal de Mato Grosso (UFMT) instacron:UFMT |
instname_str |
Universidade Federal de Mato Grosso (UFMT) |
instacron_str |
UFMT |
institution |
UFMT |
reponame_str |
Repositório Institucional da UFMT |
collection |
Repositório Institucional da UFMT |
repository.name.fl_str_mv |
Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT) |
repository.mail.fl_str_mv |
jordanbiblio@gmail.com |
_version_ |
1800846261337718784 |