Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT

Detalhes bibliográficos
Autor(a) principal: Souza, Paulo César Fernandes de
Data de Publicação: 2017
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFMT
Texto Completo: http://ri.ufmt.br/handle/1/4265
Resumo: Cervical cancer is considered a public health problem because of its magnitude and occurrence in developing and less developed countries. Objective: To analyze the mortality rate, mortality and population survival in cervical cancer patients in Greater Cuiabá- MT. Methods: An ecological retrospective temporal and longitudinal series of five-year global survival, using information from the Mortality Information System and the PopulationBased Cancer Registry of Greater Cuiabá-MT. Incidence and mortality rates, standardized by the world standard population and gross rates were calculated from the population denominations made available by the Brazilian Institute of Geography and Statistics. Trend analysis was performed using the Joinpoint regression to estimate the Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC). The survival time was estimated from the date of diagnosis until the date of death and its probability accumulated by the Kaplan - Meier method, and to verify differences in the survival curves, the log - rank test was performed and Cox proportional hazards were calculated. Results: Cervical cancer incidence and mortality rates were higher than 20 new cases per 100,000 women and 5 deaths per 100,000 women. The trend of cervical cancer mortality, without redistribution and after redistribution, was a statistically significant reduction throughout the period (APC = -1.0% CI95% -2.0, -0.0 and -1.8; -0.2 p <0.05) respectively. The incidence of carcinoma in situ presented a tendency for stability and for cancer of the invading cervix, there was a reduction (APC = -8.4% CI95% -12.2; -4.1 p <0.05). At age, the trend remained stable in mortality, except for 60-69 years, there was a reduction (APC = -3.9% CI95% -6.9; -0.9) and in the incidence there was a reduction in the age groups from 30 to 69 years for invasive cervical cancer, and in situ there was an increase in the age group ≤ 30 years (APC = 21.1% CI95%: 2.4; 43.2). In relation to survival, 916 new cases of invasive cervical cancer were followed in the period from 01/01/2000 to 12/31/2014. Overall survival in the first year was 82.43%, in five years, 63.06%. In the Cox proportional hazards model, there was an increased risk of death for the age category ≥ 60 years (RR 1.87, 95% CI: 1.42, 2.46) and in the other neoplasms group (RR 2.14, 95%: 1.30, 3.51). Conclusion: The trend was to reduce the incidence of invasive cervical cancer and stability to carcinoma in situ. Mortality was reduced. However, observed patterns of incidence, mortality and overall survival were similar to those in the developing and least developed regions of the world, reflecting failures in access to early detection as well as timely provision of adequate treatment.
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spelling Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MTNeoplasias do colo do úteroIncidênciaMortalidadeTendênciasSobrevidaCNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVAUterine cervical neoplasmsIncidenceMortalityTrendSurvivalCervical cancer is considered a public health problem because of its magnitude and occurrence in developing and less developed countries. Objective: To analyze the mortality rate, mortality and population survival in cervical cancer patients in Greater Cuiabá- MT. Methods: An ecological retrospective temporal and longitudinal series of five-year global survival, using information from the Mortality Information System and the PopulationBased Cancer Registry of Greater Cuiabá-MT. Incidence and mortality rates, standardized by the world standard population and gross rates were calculated from the population denominations made available by the Brazilian Institute of Geography and Statistics. Trend analysis was performed using the Joinpoint regression to estimate the Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC). The survival time was estimated from the date of diagnosis until the date of death and its probability accumulated by the Kaplan - Meier method, and to verify differences in the survival curves, the log - rank test was performed and Cox proportional hazards were calculated. Results: Cervical cancer incidence and mortality rates were higher than 20 new cases per 100,000 women and 5 deaths per 100,000 women. The trend of cervical cancer mortality, without redistribution and after redistribution, was a statistically significant reduction throughout the period (APC = -1.0% CI95% -2.0, -0.0 and -1.8; -0.2 p <0.05) respectively. The incidence of carcinoma in situ presented a tendency for stability and for cancer of the invading cervix, there was a reduction (APC = -8.4% CI95% -12.2; -4.1 p <0.05). At age, the trend remained stable in mortality, except for 60-69 years, there was a reduction (APC = -3.9% CI95% -6.9; -0.9) and in the incidence there was a reduction in the age groups from 30 to 69 years for invasive cervical cancer, and in situ there was an increase in the age group ≤ 30 years (APC = 21.1% CI95%: 2.4; 43.2). In relation to survival, 916 new cases of invasive cervical cancer were followed in the period from 01/01/2000 to 12/31/2014. Overall survival in the first year was 82.43%, in five years, 63.06%. In the Cox proportional hazards model, there was an increased risk of death for the age category ≥ 60 years (RR 1.87, 95% CI: 1.42, 2.46) and in the other neoplasms group (RR 2.14, 95%: 1.30, 3.51). Conclusion: The trend was to reduce the incidence of invasive cervical cancer and stability to carcinoma in situ. Mortality was reduced. However, observed patterns of incidence, mortality and overall survival were similar to those in the developing and least developed regions of the world, reflecting failures in access to early detection as well as timely provision of adequate treatment.O câncer do colo do útero é considerado um problema de saúde pública em virtude da sua magnitude e ocorrência em países em desenvolvimento e menos desenvolvidos. Objetivo: analisar a tendência da incidência, mortalidade e a sobrevida populacional para o câncer do colo do útero na Grande Cuiabá-MT. Método: Estudo ecológico de série temporal e longitudinal retrospectivo de sobrevida global de cinco anos, em que utilizou-se informações do Sistema de Informações sobre Mortalidade e do Registro de Câncer de Base Populacional da Grande Cuiabá. Foram calculadas taxas de incidência e de mortalidade, padronizadas pela população padrão mundial e taxas brutas a partir dos denominadores populacionais disponibilizados pelo Instituto Brasileiro de Geografia e Estatística. As análises das tendências foram realizadas por meio da regressão de Joinpoint para estimar a Variação Percentual Anual (APC – do inglês, Annual Percent Change) e a Variação Percentual Média Anual (AAPC – do inglês, Average Annual Percent Change). O tempo de sobrevida foi estimado da data de diagnóstico até a data do óbito e sua probabilidade acumulada pelo método Kaplan – Meier, e para verificar diferenças nas curvas de sobrevida foi realizado o teste de log-rank e calculado os riscos proporcionais de Cox. Resultados: As taxas de incidência e mortalidade por câncer do colo útero foram superiores a 20 casos novos por 100 mil mulheres e de 5 óbitos por 100 mil mulheres. A tendência da mortalidade por câncer do colo do útero, sem redistribuição e após redistribuição, foi de redução estatisticamente significativa em todo periodo (APC = -1,0% IC95% -2,0; -0,0 e -1,8; -0,2 p<0,05) respectivamente. A incidência de carcinoma in situ apresentou tendência de estabilidade e para o câncer do colo útero invasor, houve redução (APC = -8,4% IC95% -12,2; -4,1 p<0,05). Nas idades a tendência se manteve estável na mortalidade, exceto de 60 a 69 anos houve redução (APC = -3.9% IC95% -6,9; -0,9) e na incidência foi houve redução nas faixas etárias a partir dos 30 a 69 anos para o câncer do colo útero invasor, e para in situ houve aumento na faixa etária ≤ 30 anos (APC = 21.1% IC95%: 2.4; 43,2). Em relação à sobrevida foram seguidos 916 casos novos de câncer do colo do útero invasor, no período de 01/01/2000 a 31/12/2014. A sobrevida global no primeiro ano foi de 82,43%, em cinco anos de 63,06%. No ajuste do modelo de risco proporcionais de Cox foi verificado risco de óbito aumentado para a categoria idade ≥ 60 anos (RR 1,87 IC95%: 1,42; 2,46) e no grupo outras neoplasias (RR 2,14 IC95%: 1,30; 3,51). Conclusão: A tendência foi de redução da incidência do câncer do colo do útero invasor e de estabilidade para o carcinoma in situ. A mortalidade apresentou redução. No entanto, os padrões observados da incidência, da mortalidade e da sobrevida global foram semelhantes aos apresentados nas regiões em desenvolvimento e menos desenvolvidas no mundo, o que reflete falhas no acesso a detecção precoce, bem como a oferta de tratamento adequado em tempo oportuno.Universidade Federal de Mato GrossoBrasilInstituto de Saúde Coletiva (ISC)UFMT CUC - CuiabáPrograma de Pós-Graduação em Saúde ColetivaEspinosa, Mariano Martínezhttp://lattes.cnpq.br/9561670286584410Espinosa, Mariano Martínez132.155.378-18http://lattes.cnpq.br/9561670286584410Galvão, Noemi Dreyer707.520.010-00http://lattes.cnpq.br/7456965189206572132.155.378-18Santos, Marceli de Oliveira823.241.077-91http://lattes.cnpq.br/2419778639256416Souza, Paulo César Fernandes de2023-06-22T16:18:29Z2017-06-012023-06-22T16:18:29Z2017-03-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSOUZA, Paulo César Fernandes de. Câncer do colo do útero: tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT. 2017. 148 f. Dissertação (Mestrado em Saúde Coletiva) - Universidade Federal de Mato Grosso, Instituto de Saúde Coletiva, Cuiabá, 2017.http://ri.ufmt.br/handle/1/4265porinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMTinstname:Universidade Federal de Mato Grosso (UFMT)instacron:UFMT2023-06-23T07:11:45Zoai:localhost:1/4265Repositório InstitucionalPUBhttp://ri.ufmt.br/oai/requestjordanbiblio@gmail.comopendoar:2023-06-23T07:11:45Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)false
dc.title.none.fl_str_mv Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
title Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
spellingShingle Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
Souza, Paulo César Fernandes de
Neoplasias do colo do útero
Incidência
Mortalidade
Tendências
Sobrevida
CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA
Uterine cervical neoplasms
Incidence
Mortality
Trend
Survival
title_short Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
title_full Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
title_fullStr Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
title_full_unstemmed Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
title_sort Câncer do colo do útero : tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT
author Souza, Paulo César Fernandes de
author_facet Souza, Paulo César Fernandes de
author_role author
dc.contributor.none.fl_str_mv Espinosa, Mariano Martínez
http://lattes.cnpq.br/9561670286584410
Espinosa, Mariano Martínez
132.155.378-18
http://lattes.cnpq.br/9561670286584410
Galvão, Noemi Dreyer
707.520.010-00
http://lattes.cnpq.br/7456965189206572
132.155.378-18
Santos, Marceli de Oliveira
823.241.077-91
http://lattes.cnpq.br/2419778639256416
dc.contributor.author.fl_str_mv Souza, Paulo César Fernandes de
dc.subject.por.fl_str_mv Neoplasias do colo do útero
Incidência
Mortalidade
Tendências
Sobrevida
CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA
Uterine cervical neoplasms
Incidence
Mortality
Trend
Survival
topic Neoplasias do colo do útero
Incidência
Mortalidade
Tendências
Sobrevida
CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA
Uterine cervical neoplasms
Incidence
Mortality
Trend
Survival
description Cervical cancer is considered a public health problem because of its magnitude and occurrence in developing and less developed countries. Objective: To analyze the mortality rate, mortality and population survival in cervical cancer patients in Greater Cuiabá- MT. Methods: An ecological retrospective temporal and longitudinal series of five-year global survival, using information from the Mortality Information System and the PopulationBased Cancer Registry of Greater Cuiabá-MT. Incidence and mortality rates, standardized by the world standard population and gross rates were calculated from the population denominations made available by the Brazilian Institute of Geography and Statistics. Trend analysis was performed using the Joinpoint regression to estimate the Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC). The survival time was estimated from the date of diagnosis until the date of death and its probability accumulated by the Kaplan - Meier method, and to verify differences in the survival curves, the log - rank test was performed and Cox proportional hazards were calculated. Results: Cervical cancer incidence and mortality rates were higher than 20 new cases per 100,000 women and 5 deaths per 100,000 women. The trend of cervical cancer mortality, without redistribution and after redistribution, was a statistically significant reduction throughout the period (APC = -1.0% CI95% -2.0, -0.0 and -1.8; -0.2 p <0.05) respectively. The incidence of carcinoma in situ presented a tendency for stability and for cancer of the invading cervix, there was a reduction (APC = -8.4% CI95% -12.2; -4.1 p <0.05). At age, the trend remained stable in mortality, except for 60-69 years, there was a reduction (APC = -3.9% CI95% -6.9; -0.9) and in the incidence there was a reduction in the age groups from 30 to 69 years for invasive cervical cancer, and in situ there was an increase in the age group ≤ 30 years (APC = 21.1% CI95%: 2.4; 43.2). In relation to survival, 916 new cases of invasive cervical cancer were followed in the period from 01/01/2000 to 12/31/2014. Overall survival in the first year was 82.43%, in five years, 63.06%. In the Cox proportional hazards model, there was an increased risk of death for the age category ≥ 60 years (RR 1.87, 95% CI: 1.42, 2.46) and in the other neoplasms group (RR 2.14, 95%: 1.30, 3.51). Conclusion: The trend was to reduce the incidence of invasive cervical cancer and stability to carcinoma in situ. Mortality was reduced. However, observed patterns of incidence, mortality and overall survival were similar to those in the developing and least developed regions of the world, reflecting failures in access to early detection as well as timely provision of adequate treatment.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
2017-03-30
2023-06-22T16:18:29Z
2023-06-22T16:18:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv SOUZA, Paulo César Fernandes de. Câncer do colo do útero: tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT. 2017. 148 f. Dissertação (Mestrado em Saúde Coletiva) - Universidade Federal de Mato Grosso, Instituto de Saúde Coletiva, Cuiabá, 2017.
http://ri.ufmt.br/handle/1/4265
identifier_str_mv SOUZA, Paulo César Fernandes de. Câncer do colo do útero: tendências de incidência, mortalidade e sobrevida na grande Cuiabá-MT. 2017. 148 f. Dissertação (Mestrado em Saúde Coletiva) - Universidade Federal de Mato Grosso, Instituto de Saúde Coletiva, Cuiabá, 2017.
url http://ri.ufmt.br/handle/1/4265
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language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Mato Grosso
Brasil
Instituto de Saúde Coletiva (ISC)
UFMT CUC - Cuiabá
Programa de Pós-Graduação em Saúde Coletiva
publisher.none.fl_str_mv Universidade Federal de Mato Grosso
Brasil
Instituto de Saúde Coletiva (ISC)
UFMT CUC - Cuiabá
Programa de Pós-Graduação em Saúde Coletiva
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMT
instname:Universidade Federal de Mato Grosso (UFMT)
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instname_str Universidade Federal de Mato Grosso (UFMT)
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institution UFMT
reponame_str Repositório Institucional da UFMT
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repository.name.fl_str_mv Repositório Institucional da UFMT - Universidade Federal de Mato Grosso (UFMT)
repository.mail.fl_str_mv jordanbiblio@gmail.com
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