ASSOCIAÇÃO ENTRE CONDIÇÕES BUCAIS E CÂNCER DE MAMA

• Autor(a) principal: Sensever, Felipe de Araujo
• Data de Publicação: 2019
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Universidade Franciscana
• Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/721
• topic: Câncer de mama; doença periodontal; periodontite; perda de dente; saúde bucal.; Breast cancer; periodontal disease; periodontitis; tooth loss; oral health.; Ciências da Saúde e da Vida

Breast cancer (BC) is one of the three most common cancers worldwide and the most common among women. Periodontitis is a prevalent infectious-inflammatory disease and is known to be associated with systemic diseases. Infectious agents and inflammatory mediators of the oral environment can cause a high and sustained systemic inflammatory condition, which may promote the pathogenesis of cancer. On the other hand, therapies against BC can cause oral complications, including mucositis, xerostomia, neurosensorial and palate changes, gingival bleeding and increased tooth loss (TL). The dissertation presents two articles. Article 1 aimed to systematically review the literature and analyze published studies seeking an association between periodontitis and BC. The search strategy was elaborated according to the searched databases, in order to find publications that investigated this theme. According to pre-established selection criteria, the resulting articles were first evaluated by title and abstract, and those included in this first phase were read in full for data extraction. The methodological quality and risk of bias of the studies were evaluated and the statistical analysis was performed. The results of the meta-analysis showed that individuals with periodontitis had a 19% higher chance of developing BC. When the periodontal clinical parameters were analyzed, no such association was observed. Patients with periodontitis are more likely to present BC, however, when periodontal clinical parameters are used to diagnose periodontitis, this association ceases to exist. Article 2 assessed the occurrence of TL and associated factors in women with BC. This is a cross-sectional study with 150 women with BC undergoing treatment at the Hospital Universitário de Santa Maria (HUSM). An interview composed of a structured questionnaire was performed to collect the variables and an oral examination to evaluate the TL. The occurrence of TL was associated with demographic variables, odontological indices and with BC characteristics. After adjustment, the occurrence of more than 12 missing teeth was 3.28 and 3.29 times higher in women with more uncommon BC and who used tamoxifen for more than 12 months, respectively. Age over 55 years, referrals made from the public health service, less use of dental services and less occurrence of dental caries were also associated with TL. Thus, demographic and dental variables, more unusual BC diagnoses, and longer tamoxifen use were associated with severe tooth loss in BC survivors.