VARIÁVEIS CLINICOPATOLÓGICAS E PERFIL IMUNO-HISTOQUÍMICO NO CÂNCER DE MAMA

• Autor(a) principal: Schaffer, Beatriz Graff
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Universidade Franciscana
• Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/933
• topic: Câncer de mama; aspectos sociodemográficos; receptores hormonais; imuno-histoquímica; subtipos moleculares.; Breast cancer; sociodemographic aspects; hormone receptors; immunohistochemistry; molecular subtypes.; Ciências da Saúde e da Vida

Breast cancer (CM) is the most commonly diagnosed form of cancer among women and represents a quarter of all female cancers. Disregarding non-melanoma skin tumors, it occupies the first most frequent position in all brazilian regions. Among the risk factors established for CM, individual, lifestyle and environmental conditions stand out that increase the probability of developing the pathology, as they can contribute to tumor initiation and progression. Usually, breast carcinomas are classified into subgroups based on histological type and grade, presence of lymphatic invasion, lymph node metastasis and expression of predictive markers such as hormone receptors and the HER2 oncoprotein. This study identified the sociodemographic profile and clinicopathological conditions of women with CM treated in a public service in the central region of Rio Grande do Sul. As sociodemographic aspects, the mean age, skin color, marital status, education level, city of residence and profession was considered. For the definition of the groups according to immunohistochemical profile, we chose a classification based on the evaluation of estrogen and progesterone receptors, Ki67 cell proliferation index and HER2 overexpression, grouped into four subtypes: luminal A, luminal B-HER2 + or - , negative triple and overexpressed HER2. Were studied 132 women with an average age of 59 years (± 12.7), of whom they declared themselves to be white (79.5%), with a partner (53.8%) and 65.2% having studied up to nine years. The most exercised activity among them was agriculture (28.0%). They used contraceptives for 10 years (median) 75.8% and did not undergo hormone replacement therapy 86.4%. At diagnosis, 71.5% had grade II tumor and 55.7% had lymph node involvement. Invasive ductal carcinoma was the most common histological type (87.9%). The most frequent molecular subtypes were Luminal B (42.4%) and Luminal A (37.9%), followed by the negative triple (12.9%) and HER2 overexpression (6.8%). Women with Luminal A subtype were older (P=0.016), also had up to nine years of schooling, while women with HER2 overexpression and negative triple, more than nine years of formal study (P=0.042). Women with Luminal A subtype most often performed household activities (P=0.004). In the present study, we identified invasive ductal carcinoma and the Luminal B subtype as the most prevalent in the participants. The factors age, education level and activity performed were associated with molecular subgroups in this population. These results can be considered favorable considering that most women with CM have a molecular subtype of good prognosis, being responsive to treatment with hormone therapy.