MODELAGEM MATEMÁTICA DE PERFIS DE LIBERAÇÃO DE FÁRMACOS A PARTIR DE NANOCARREADORES

• Autor(a) principal: Pires, Rafaeli Oleques
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Universidade Franciscana
• Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/491
• topic: Nanociência; Modelagem Matemática; Nanocarreador; Nanoscience; Mathematical Modelling; Nanocarrier; Biociências e Nanomateriais

From the 60s, a debate about a new and promising world-wide technologies started, and it was called nanotechnology. Together with the global growth, many fields of research had started to use in their studies, for example, in the pharmaceutical area. Among these innovations, we can include the discovery of new composites, biodegradable products and the development of carries in nanoscale. Among the most used nanocarries there are nanosphere and nanocapsules, showing controlled release compared to conventional drug delivery systems. The release process was studied by some authors that described this process using mathematical equations, one for each use. However, actually, there is no mathematical equation that represents the behavior of the nanocarries, emphasizing the factors relevant at nanoscale. Then, the present study analyzed a specific carrier - nanocapsule - to develop a mathematical equation that represents the behavior of the drug release from polymeric nanocapsules. For the construction of the mathematical model, we used mathematical modeling as methodology. We proved there isn’t change in particle size during the release process, when used poly ( -caprolactone). After that, we noticed that the parameters that interfere in the release process were drug solubility in the oil core of nanocapsule and the encapsulation efficiency. Based in these two parameters, the mathematical model was constructed and then validated, showing to be an good model to describe the drug release profiles from nanocapsules.