ASSOCIAÇÃO ENTRE NÍVEIS SÉRICOS DE VITAMINA D E CÂNCER COLORRETAL: UMA REVISÃO SISTEMÁTICA

• Autor(a) principal: Camargo, Tiane
• Data de Publicação: 2020
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional Universidade Franciscana
• Texto Completo: http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/877
• topic: Fatores de risco. Intestino. Neoplasias. Vitamina D.; Risk factors. Intestine. Neoplasms. Vitamin D.; Ciências da Saúde e da Vida

Currently, one of the world's major public health problems is cancer, which is a chronic, degenerative disease that affects various dimensions of human life, causing economic impact on society because it needs long-term, costly specialized treatment. Colorectal cancer (CRC) has epidemiological relevance worldwide as it is the third most commonly diagnosed malignant neoplasm and the fourth leading cause of cancer death. In Brazil it is the third most frequent cancer in men and the second among women. CRC is a multifactorial disease influenced by genetic, environmental and lifestyle-related factors. Among these factors, the possible influence of vitamin D has been increasingly studied. With the understanding of several aspects of vitamin D physiology, from biochemical and molecular studies, its active form, D 1,25-dihydroxyvitamin, was recognized as a steroid hormone integrating a metabolic axis: the endocrinological system D vitamin; which was pointed out as a regulator of proliferation and differentiation of human cancer cells. Due to this fact, the main objective of this work is to evaluate the association of serum levels of D vitamin with CRC. This is a systematic review-type study, which occurred in the period between August 2018 and January 2020. The present work contributes to medical literature that measures the compilation of several studies, evidence that the effect of vitamin D appears to be positive on prevention or survival in patients with CRC.