NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Universidade Franciscana |
Texto Completo: | http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/789 |
Resumo: | Nanotechnology is an interdisciplinary scientific field where it is possible to manipulate, alter and develop new materials at the nanoscale, changing their properties. It finds applications in the sectors of energy, electronics, pharmacy medicine and cosmetology. In the pharmaceutical and cosmetic areas there is the production of nanocarriers for pharmaceuticals, which can protect, encapsulate and release pharmacologically active compounds. In our study we chose the nanoemulsion as carrier, since it is widely used as a vehicle for drugs, by the cosmetic and pharmaceutical industry. The nanoemulsion has better sensory characteristics maintaining a non-oily texture. The drug used was diosgenin. Diosgenin is a steroidal sapogenin found in roots of wild yam (Dioscorea villosa). Diosgenin has a structure similar to progesterone and estradiol and is used as a chemical precursor in the industrial preparation of oral contraceptive pills and steroid hormones. The general objective was to produce and evaluate diosgenin containing nanoemulsions, aiming at the choice of a stable formulation. Nanoemulsions at concentrations 1 mg/mL, 3 mg/mL and 5 mg/mL were produced using the high energy emulsification method. A spectrophotometric method was co-validated in the visible region to identify Diosgenin in nanoemulsions. The physico-chemical characterization and the stability study at different temperatures allowed to evaluate formulations of diosgenin nanoemulsions at concentration 1mg / mL and white nanocapsules for 90 days. The characterization of the diosgenin containing nanoemulsions showed a nanometric and homogeneous particle diameter, with negative zeta potential, low polydispersity index and slightly acidic pH, which guarantees the quality and stability of the diosgenin nanoemulsion, compatibility for topical use and the possibility reaching the deepest layers of the skin, potentializing the effects of diosgenin. The best condition for storage of nanoemulsions without losing their physico-chemical characteristics during the 90-day period was under refrigeration. |
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Gomes, PatríciaMortari, Sérgio RobertoWingert , Nathalie RibeiroRhoden, Cristiano Rodrigo BohnEsimann, Priscila2019-08-26T20:36:37Z2019-03-28Esimann, Priscila. NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE. 2019. 59f. Universidade Franciscana. Santa Maria - RShttp://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/789Nanotechnology is an interdisciplinary scientific field where it is possible to manipulate, alter and develop new materials at the nanoscale, changing their properties. It finds applications in the sectors of energy, electronics, pharmacy medicine and cosmetology. In the pharmaceutical and cosmetic areas there is the production of nanocarriers for pharmaceuticals, which can protect, encapsulate and release pharmacologically active compounds. In our study we chose the nanoemulsion as carrier, since it is widely used as a vehicle for drugs, by the cosmetic and pharmaceutical industry. The nanoemulsion has better sensory characteristics maintaining a non-oily texture. The drug used was diosgenin. Diosgenin is a steroidal sapogenin found in roots of wild yam (Dioscorea villosa). Diosgenin has a structure similar to progesterone and estradiol and is used as a chemical precursor in the industrial preparation of oral contraceptive pills and steroid hormones. The general objective was to produce and evaluate diosgenin containing nanoemulsions, aiming at the choice of a stable formulation. Nanoemulsions at concentrations 1 mg/mL, 3 mg/mL and 5 mg/mL were produced using the high energy emulsification method. A spectrophotometric method was co-validated in the visible region to identify Diosgenin in nanoemulsions. The physico-chemical characterization and the stability study at different temperatures allowed to evaluate formulations of diosgenin nanoemulsions at concentration 1mg / mL and white nanocapsules for 90 days. The characterization of the diosgenin containing nanoemulsions showed a nanometric and homogeneous particle diameter, with negative zeta potential, low polydispersity index and slightly acidic pH, which guarantees the quality and stability of the diosgenin nanoemulsion, compatibility for topical use and the possibility reaching the deepest layers of the skin, potentializing the effects of diosgenin. The best condition for storage of nanoemulsions without losing their physico-chemical characteristics during the 90-day period was under refrigeration.A nanotecnologia é um campo científico interdisciplinar onde é possivel manipular, alterar e desenvolver novos materiais em escala nanométrica, ocorrendo alteração de suas propriedades. Encontra aplicações nos setores de energia, eletrônica, medicina farmácia e cosmetologia. Nas áreas farmacêutica e de cosméticos ocorre a produção de nanocarreadores para fármacos, podendo proteger, encapsular e liberar compostos farmacologicamente ativos. Em nosso estudo escolhemos a nanoemulsão como carreador, pois é largamente utilizada como veículo para fámacos, pela indústria cosmética e farmacêutica. A nanoemulsão possui melhores características sensoriais mantendo uma textura não-oleosa. O fármaco utilizado foi a Diosgenina. A Diosgenina é uma sapogenina esteroidal, encontrada em raízes do inhame selvagem (Dioscorea villosa). A Diosgenina possui estrutura semelhante à progesterona e ao estradiol e é usada como um precursor químico na preparação industrial de pílulas anticoncepcionais orais e hormônios esteroides. O objetivo geral foi produzir e avaliar nanoemulsões contendo Diosgenina, visando a escolha de uma formulação estável. Foram produzidas nanoemulsões nas concentrações 1mg/mL, 3mg/mL e 5mg/mL utilizando o método de emulsificação sob alta energia. Foi co-validado um método por espectrofotometria na região do visível para identificar a Diosgenina nas nanoemulsões. A caracterização físico-química e o estudo de estabilidade em diferentes temperaturas permitiu avaliar formulações de nanoemulsões de diosgenina na concentração 1mg/mL e nanocápsulas brancas por 90 dias. A caracterização das nanoemulsões contendo diosgenina mostrou diâmetro médio de partícula na escala nanométrica e homogênea, com potencial zeta negativo, baixo índice de polidispersão e pH levemente ácido, o que garantem a qualidade e estabilidade da nanoemulsão de diosgenina, compatibilidade para uso tópico e a possibilidade de alcance nas camadas mais profundas da pele, potencializando os efeitos da diosgenina. A melhor condição para o armazenamento das nanoemulsões sem perder suas características físico-químicas durante o período de 90 dias foi sob refrigeração (geladeira).Submitted by MARCIA ROVADOSCHI (marciar@unifra.br) on 2019-08-26T20:36:37Z No. of bitstreams: 2 Dissertacao_PriscilaEismann.pdf: 1081060 bytes, checksum: 2ac9ed5f3ebc2df9a3ff1f317be78de1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2019-08-26T20:36:37Z (GMT). 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dc.title.por.fl_str_mv |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
title |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
spellingShingle |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE Esimann, Priscila Nanocarreadores, Hormônio Esteroide, Estabilidade, Nanotecnologia Nanocarriers, Steroid Hormone , Stability, Nanotechnology Nanociências |
title_short |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
title_full |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
title_fullStr |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
title_full_unstemmed |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
title_sort |
NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE |
author |
Esimann, Priscila |
author_facet |
Esimann, Priscila |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Gomes, Patrícia |
dc.contributor.advisor-co1.fl_str_mv |
Mortari, Sérgio Roberto |
dc.contributor.referee1.fl_str_mv |
Wingert , Nathalie Ribeiro |
dc.contributor.referee2.fl_str_mv |
Rhoden, Cristiano Rodrigo Bohn |
dc.contributor.author.fl_str_mv |
Esimann, Priscila |
contributor_str_mv |
Gomes, Patrícia Mortari, Sérgio Roberto Wingert , Nathalie Ribeiro Rhoden, Cristiano Rodrigo Bohn |
dc.subject.por.fl_str_mv |
Nanocarreadores, Hormônio Esteroide, Estabilidade, Nanotecnologia |
topic |
Nanocarreadores, Hormônio Esteroide, Estabilidade, Nanotecnologia Nanocarriers, Steroid Hormone , Stability, Nanotechnology Nanociências |
dc.subject.eng.fl_str_mv |
Nanocarriers, Steroid Hormone , Stability, Nanotechnology |
dc.subject.cnpq.fl_str_mv |
Nanociências |
description |
Nanotechnology is an interdisciplinary scientific field where it is possible to manipulate, alter and develop new materials at the nanoscale, changing their properties. It finds applications in the sectors of energy, electronics, pharmacy medicine and cosmetology. In the pharmaceutical and cosmetic areas there is the production of nanocarriers for pharmaceuticals, which can protect, encapsulate and release pharmacologically active compounds. In our study we chose the nanoemulsion as carrier, since it is widely used as a vehicle for drugs, by the cosmetic and pharmaceutical industry. The nanoemulsion has better sensory characteristics maintaining a non-oily texture. The drug used was diosgenin. Diosgenin is a steroidal sapogenin found in roots of wild yam (Dioscorea villosa). Diosgenin has a structure similar to progesterone and estradiol and is used as a chemical precursor in the industrial preparation of oral contraceptive pills and steroid hormones. The general objective was to produce and evaluate diosgenin containing nanoemulsions, aiming at the choice of a stable formulation. Nanoemulsions at concentrations 1 mg/mL, 3 mg/mL and 5 mg/mL were produced using the high energy emulsification method. A spectrophotometric method was co-validated in the visible region to identify Diosgenin in nanoemulsions. The physico-chemical characterization and the stability study at different temperatures allowed to evaluate formulations of diosgenin nanoemulsions at concentration 1mg / mL and white nanocapsules for 90 days. The characterization of the diosgenin containing nanoemulsions showed a nanometric and homogeneous particle diameter, with negative zeta potential, low polydispersity index and slightly acidic pH, which guarantees the quality and stability of the diosgenin nanoemulsion, compatibility for topical use and the possibility reaching the deepest layers of the skin, potentializing the effects of diosgenin. The best condition for storage of nanoemulsions without losing their physico-chemical characteristics during the 90-day period was under refrigeration. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-08-26T20:36:37Z |
dc.date.issued.fl_str_mv |
2019-03-28 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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dc.identifier.citation.fl_str_mv |
Esimann, Priscila. NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE. 2019. 59f. Universidade Franciscana. Santa Maria - RS |
dc.identifier.uri.fl_str_mv |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/789 |
identifier_str_mv |
Esimann, Priscila. NANOEMULSÕES CONTENDO DIOSGENINA: PRODUÇÃO E ESTUDO DE ESTABILIDADE. 2019. 59f. Universidade Franciscana. Santa Maria - RS |
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http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/789 |
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por |
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por |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Franciscana |
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Programa de Pós-Graduação em Nanociências |
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UFN |
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Brasil |
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Biociências e Nanomateriais |
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Universidade Franciscana |
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