Dietary açai attenuates hepatic steatosis via adiponectin-mediated effects on lipid metabolism in high-fat diet mice.

• Autor(a) principal: Guerra, Joyce Ferreira da Costa
• Data de Publicação: 2015
• Outros Autores: Maciel, Poliane Silva, Abreu, Isabel Cristina Mallosto Emerich de, Pereira, Renata Rebeca, Silva, Maísa, Cardoso, Leandro de Morais, Sant'Ana, Helena Maria Pinheiro, Lima, Wanderson Geraldo de, Silva, Marcelo Eustáquio, Pedrosa, Maria Lúcia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/6231; https://doi.org/10.1016/j.jff.2015.01.025
• topic: Euterpe oleracea mart; Peroxisome proliferator-activated; Nonalcoholic fatty liver disease

Polyphenols, especially anthocyanins, have been considered promising for the prevention of nonalcoholic fatty liver disease (NAFLD). This study investigated whether açai (Euterpe oleracea Mart.), a source of anthocyanins and recognized as one of the new “superfruits”, could alleviate high-fat diet (HFD)-induced NAFLD in mice. In HFD mice, aqueous açai extract (AAE) administration (3 g/kg) for six weeks improved insulin resistance index and increased adiponectin mRNA expression in adipose tissue and serum levels. Furthermore, AAE decreased the total liver triacylglycerol content and attenuated HFD-induced hepatic steatosis. This reduced hepatic lipid content was associated with AAE-mediated up-regulation of genes involved in adiponectin signaling, including adiponectin receptor 2, PPAR-α, and its target gene, carnitine palmitoyltransferase. Thus, dietary açai can protect liver from steatosis through its enhancement of adiponectin levels, improvement of insulin sensitivity, and increase in PPAR-α-mediated fatty acid oxidation.