Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/11017 |
Resumo: | Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species. |
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Ferraz Filha, Zilma SchimithFerrari, Fernanda CristinaAraújo, Marcela Carolina de Paula MichelBernardes, Ana Catharina Fernandes Pereira FerreiraGuimarães, Dênia Antunes Saúde2019-04-15T14:36:46Z2019-04-15T14:36:46Z2017FERRAZ FILHA, Z. S. et al. Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 1-11, 2017. Disponível em: <https://www.hindawi.com/journals/ecam/2017/2712108/>. Acesso em: 25 fev. 2019.17414288http://www.repositorio.ufop.br/handle/123456789/11017Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigoinfo:eu-repo/semantics/openAccessEffects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/11017/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_EffectsAqueousExtract.pdfARTIGO_EffectsAqueousExtract.pdfapplication/pdf1951675http://www.repositorio.ufop.br/bitstream/123456789/11017/1/ARTIGO_EffectsAqueousExtract.pdf8e0f5589df67b7890dc80083d5801290MD51123456789/110172019-04-15 10:36:46.863oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-15T14:36:46Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
title |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
spellingShingle |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Ferraz Filha, Zilma Schimith |
title_short |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
title_full |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
title_fullStr |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
title_full_unstemmed |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
title_sort |
Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. |
author |
Ferraz Filha, Zilma Schimith |
author_facet |
Ferraz Filha, Zilma Schimith Ferrari, Fernanda Cristina Araújo, Marcela Carolina de Paula Michel Bernardes, Ana Catharina Fernandes Pereira Ferreira Guimarães, Dênia Antunes Saúde |
author_role |
author |
author2 |
Ferrari, Fernanda Cristina Araújo, Marcela Carolina de Paula Michel Bernardes, Ana Catharina Fernandes Pereira Ferreira Guimarães, Dênia Antunes Saúde |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ferraz Filha, Zilma Schimith Ferrari, Fernanda Cristina Araújo, Marcela Carolina de Paula Michel Bernardes, Ana Catharina Fernandes Pereira Ferreira Guimarães, Dênia Antunes Saúde |
description |
Tabebuia species (Bignoniaceae) have long been used in folk medicine as anti-inflammatory, antirheumatic, antimicrobial, and antitumor. The aim of this study was to investigate if aqueous extract from the leaves (AEL) of Tabebuia roseoalba (Ridl.) Sandwith, Bignoniaceae, and its constituents could be useful to decrease serum uric acid levels and restrain the gout inflammatory process. HPLC analysis identified caffeic acid and chlorogenic acid in AEL. Antihyperuricemic effects and inhibition of liver XOD (xanthine oxidoreductase) by AEL and identified compounds were evaluated in hyperuricemic mice. Anti-inflammatory activity was evaluated on MSU (monosodium urate) crystal-induced paw edema. In addition, AEL antioxidant activity in vitro was evaluated. AEL, caffeic, and chlorogenic acids were able to reduce serum uric acid levels in hyperuricemic mice probably through inhibition of liver xanthine oxidase activity and significantly decreased the paw edema induced by MSU crystals. AEL showed significant antioxidant activity in all evaluated assays. The results show that the AEL of Tabebuia roseoalba can be a promising agent for treatment for gout and inflammatory diseases. We suggest that caffeic and chlorogenic acids may be responsible for the activities demonstrated by the species. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2019-04-15T14:36:46Z |
dc.date.available.fl_str_mv |
2019-04-15T14:36:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERRAZ FILHA, Z. S. et al. Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 1-11, 2017. Disponível em: <https://www.hindawi.com/journals/ecam/2017/2712108/>. Acesso em: 25 fev. 2019. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/11017 |
dc.identifier.issn.none.fl_str_mv |
17414288 |
identifier_str_mv |
FERRAZ FILHA, Z. S. et al. Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation. Evidence-based Complementary and Alternative Medicine, v. 2017, p. 1-11, 2017. Disponível em: <https://www.hindawi.com/journals/ecam/2017/2712108/>. Acesso em: 25 fev. 2019. 17414288 |
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http://www.repositorio.ufop.br/handle/123456789/11017 |
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eng |
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eng |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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