Splenectomy does not interfere with immune response to Leishmania major infection in mice.

Detalhes bibliográficos
Autor(a) principal: Maioli, Tatiani Uceli
Data de Publicação: 2007
Outros Autores: Carneiro, Cláudia Martins, Assis, Frankcinéia Aparecida de, Faria, Ana Maria Caetano de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1409
Resumo: Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.
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spelling Maioli, Tatiani UceliCarneiro, Cláudia MartinsAssis, Frankcinéia Aparecida deFaria, Ana Maria Caetano de2012-09-19T17:48:06Z2012-09-19T17:48:06Z2007MAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.00088749http://www.repositorio.ufop.br/handle/123456789/1409Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.Leishmania majorImmune protectionSpleenSplenectomy does not interfere with immune response to Leishmania major infection in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Cellular Immunology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990466243.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1409/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALARTIGO_SplenectomyInterfereImmune.pdfARTIGO_SplenectomyInterfereImmune.pdfapplication/pdf1202642http://www.repositorio.ufop.br/bitstream/123456789/1409/1/ARTIGO_SplenectomyInterfereImmune.pdf0468e09baf995dd070e3c108a94d80a9MD51123456789/14092019-04-24 10:53:27.103oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-24T14:53:27Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title Splenectomy does not interfere with immune response to Leishmania major infection in mice.
spellingShingle Splenectomy does not interfere with immune response to Leishmania major infection in mice.
Maioli, Tatiani Uceli
Leishmania major
Immune protection
Spleen
title_short Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_full Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_fullStr Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_full_unstemmed Splenectomy does not interfere with immune response to Leishmania major infection in mice.
title_sort Splenectomy does not interfere with immune response to Leishmania major infection in mice.
author Maioli, Tatiani Uceli
author_facet Maioli, Tatiani Uceli
Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
author_role author
author2 Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
author2_role author
author
author
dc.contributor.author.fl_str_mv Maioli, Tatiani Uceli
Carneiro, Cláudia Martins
Assis, Frankcinéia Aparecida de
Faria, Ana Maria Caetano de
dc.subject.por.fl_str_mv Leishmania major
Immune protection
Spleen
topic Leishmania major
Immune protection
Spleen
description Spleen is one of the largest lymphoid organs in the body; it harbors immune cells including antigen presenting cells, B and T lymphocytes. It has an important role in humoral and cellular immune responses. Herein we investigated the role of spleen in the immune response to experimental Leishmania major infection. It is known that C57BL/6 mice are resistant to L. major infection whereas BALB/c mice are susceptible. Although splenectomy was associated with reduced serum levels of IFN-gamma, absence of the spleen did not change the profile of L. major infection in the resistant C57BL/6 and BALB/c susceptible mice. Both strains of mice maintained the same profile of cytokine production in regional lymph nodes after splenectomy and responded in the same way against the infection. Only splenectomized BALB/c mice had a reduction in IL-4 and IL-10 production by lymph node cells early in infection. Our data suggest that, in localized infections, regional lymph nodes may replace efficiently the immunological role of spleen in the cellular and humoral immune responses.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2012-09-19T17:48:06Z
dc.date.available.fl_str_mv 2012-09-19T17:48:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/1409
dc.identifier.issn.none.fl_str_mv 00088749
identifier_str_mv MAIOLI, T. U. et al. Splenectomy does not interfere with immune response to Leishmania major infection in mice. Cellular Immunology, v. 249, n. 1, p. 1-7, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0008874907002225>. Acesso em: 19 set. 2012.
00088749
url http://www.repositorio.ufop.br/handle/123456789/1409
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http://www.repositorio.ufop.br/bitstream/123456789/1409/1/ARTIGO_SplenectomyInterfereImmune.pdf
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