A tetravalent dengue nanoparticle stimulates antibody production in mice.
Main Author: | |
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Publication Date: | 2012 |
Other Authors: | , , , , , , , , , , |
Format: | Article |
Language: | por |
Source: | Repositório Institucional da UFOP |
Download full: | http://www.repositorio.ufop.br/handle/123456789/7383 https://doi.org/10.1186/1477-3155-10-13 |
Summary: | Dengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. Currently, there are no licensed vaccines or antiviral drugs to prevent or treat dengue infections. Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines. |
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Silva, ElisângelaOrsi, MarianaAndrade, Ângela LeãoDomingues, Rosana ZacariasSilva, Breno de MelloAraújo, Helena dePimenta, Paulo Filemon PaolucciDiamond, MichaelRocha, EliseuKroon, Erna GeessienMalaquias, Luiz Cosme CottaCoelho, Luiz2017-03-16T13:34:41Z2017-03-16T13:34:41Z2012SILVA, E. F. et al. A tetravalent dengue nanoparticle stimulates antibody production in mice. Journal of Nanobiotechnology, v. 10, p. 13, 2012. Disponível em: <https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-10-13> Acesso em: 19 fev. 2017.1477-3155http://www.repositorio.ufop.br/handle/123456789/7383https://doi.org/10.1186/1477-3155-10-13Dengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. Currently, there are no licensed vaccines or antiviral drugs to prevent or treat dengue infections. Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessInactivated Dengue vírusNanoparticlesHumoral responseA tetravalent dengue nanoparticle stimulates antibody production in mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleporreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/7383/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_TetravalentDengueNanoparticle.pdfARTIGO_TetravalentDengueNanoparticle.pdfapplication/pdf557851http://www.repositorio.ufop.br/bitstream/123456789/7383/1/ARTIGO_TetravalentDengueNanoparticle.pdfeab656b5a62e97b933690a46b5145411MD51123456789/73832019-11-01 09:10:37.494oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-11-01T13:10:37Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
title |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
spellingShingle |
A tetravalent dengue nanoparticle stimulates antibody production in mice. Silva, Elisângela Inactivated Dengue vírus Nanoparticles Humoral response |
title_short |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
title_full |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
title_fullStr |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
title_full_unstemmed |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
title_sort |
A tetravalent dengue nanoparticle stimulates antibody production in mice. |
author |
Silva, Elisângela |
author_facet |
Silva, Elisângela Orsi, Mariana Andrade, Ângela Leão Domingues, Rosana Zacarias Silva, Breno de Mello Araújo, Helena de Pimenta, Paulo Filemon Paolucci Diamond, Michael Rocha, Eliseu Kroon, Erna Geessien Malaquias, Luiz Cosme Cotta Coelho, Luiz |
author_role |
author |
author2 |
Orsi, Mariana Andrade, Ângela Leão Domingues, Rosana Zacarias Silva, Breno de Mello Araújo, Helena de Pimenta, Paulo Filemon Paolucci Diamond, Michael Rocha, Eliseu Kroon, Erna Geessien Malaquias, Luiz Cosme Cotta Coelho, Luiz |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Elisângela Orsi, Mariana Andrade, Ângela Leão Domingues, Rosana Zacarias Silva, Breno de Mello Araújo, Helena de Pimenta, Paulo Filemon Paolucci Diamond, Michael Rocha, Eliseu Kroon, Erna Geessien Malaquias, Luiz Cosme Cotta Coelho, Luiz |
dc.subject.por.fl_str_mv |
Inactivated Dengue vírus Nanoparticles Humoral response |
topic |
Inactivated Dengue vírus Nanoparticles Humoral response |
description |
Dengue is a major public health problem worldwide, especially in the tropical and subtropical regions of the world. Infection with a single Dengue virus (DENV) serotype causes a mild, self-limiting febrile illness called dengue fever. However, a subset of patients experiencing secondary infection with a different serotype progresses to the severe form of the disease, dengue hemorrhagic fever/dengue shock syndrome. Currently, there are no licensed vaccines or antiviral drugs to prevent or treat dengue infections. Biodegradable nanoparticles coated with proteins represent a promising method for in vivo delivery of vaccines. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2017-03-16T13:34:41Z |
dc.date.available.fl_str_mv |
2017-03-16T13:34:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, E. F. et al. A tetravalent dengue nanoparticle stimulates antibody production in mice. Journal of Nanobiotechnology, v. 10, p. 13, 2012. Disponível em: <https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-10-13> Acesso em: 19 fev. 2017. |
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http://www.repositorio.ufop.br/handle/123456789/7383 |
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1477-3155 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1186/1477-3155-10-13 |
identifier_str_mv |
SILVA, E. F. et al. A tetravalent dengue nanoparticle stimulates antibody production in mice. Journal of Nanobiotechnology, v. 10, p. 13, 2012. Disponível em: <https://jnanobiotechnology.biomedcentral.com/articles/10.1186/1477-3155-10-13> Acesso em: 19 fev. 2017. 1477-3155 |
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http://www.repositorio.ufop.br/handle/123456789/7383 https://doi.org/10.1186/1477-3155-10-13 |
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