Fast detection of arbitrarily shaped disease clusters.

• Autor(a) principal: Assunção, Renato Martins
• Data de Publicação: 2006
• Outros Autores: Costa, Marcelo Azevedo, Tavares, Andréa Iabrudi, Ferreira, Sabino José
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1766
• topic: Disease clusters; Scan statistics; Spatial cluster; Spatial statistics

Disease cluster detection and evaluation have commonly used spatial statistics methods that scan the map with a fixed circular window to locate candidate clusters. Recently, there has been interest in searching for clusters with arbitrary shape. The circular scan test retains high power of detecting a cluster, but does not necessarily identify the exact regions contained in a non-circular cluster particularly well. We propose, implement and evaluate a new procedure that is fast and produces clusters estimates of arbitrary shape in a rich class of possible cluster candidates. We showed that our methods contain the so-called upper level set method as a particular case. We present a power study of our method and, among other results, the main conclusion is that the likelihood-based arbitrarily shaped scan method is not appropriate to _nd a cluster estimate. When the parameter space includes the set of all possible spatial clusters in a map, a large and discrete parameter space, maximum likely cluster estimates tend to overestimate the true cluster by a large extent. This calls for a new approach different from the maximum likelihood method for this important public health problem.