Psychotria viridis : chemical constituents from leaves and biological properties.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/8637 |
Resumo: | The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
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Psychotria viridis : chemical constituents from leaves and biological properties.RubiaceaeThe phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.2017-08-31T15:54:16Z2017-08-31T15:54:16Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017.1678-2690http://www.repositorio.ufop.br/handle/123456789/8637Os trabalhos publicados no periódico Anais da Academia Brasileira de Ciências, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Anais da Academia Brasileira de Ciências <http://www.scielo.br/scielo.php?script=sci_serial&pid=0001-3765&lng=en&nrm=iso>. Acesso em: 23 jan. 2020.info:eu-repo/semantics/openAccessSoares, Débora Barbosa da SilvaDuarte, Lucienir PainsCavalcanti, André DiasSilva, Fernando CésarBraga, Ariadne DuarteLopes, Miriam Teresa PazTakahashi, Jacqueline AparecidaVieira Filho, Sidney Augustoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-01-26T20:54:24Zoai:repositorio.ufop.br:123456789/8637Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-01-26T20:54:24Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Psychotria viridis : chemical constituents from leaves and biological properties. |
title |
Psychotria viridis : chemical constituents from leaves and biological properties. |
spellingShingle |
Psychotria viridis : chemical constituents from leaves and biological properties. Soares, Débora Barbosa da Silva Rubiaceae |
title_short |
Psychotria viridis : chemical constituents from leaves and biological properties. |
title_full |
Psychotria viridis : chemical constituents from leaves and biological properties. |
title_fullStr |
Psychotria viridis : chemical constituents from leaves and biological properties. |
title_full_unstemmed |
Psychotria viridis : chemical constituents from leaves and biological properties. |
title_sort |
Psychotria viridis : chemical constituents from leaves and biological properties. |
author |
Soares, Débora Barbosa da Silva |
author_facet |
Soares, Débora Barbosa da Silva Duarte, Lucienir Pains Cavalcanti, André Dias Silva, Fernando César Braga, Ariadne Duarte Lopes, Miriam Teresa Paz Takahashi, Jacqueline Aparecida Vieira Filho, Sidney Augusto |
author_role |
author |
author2 |
Duarte, Lucienir Pains Cavalcanti, André Dias Silva, Fernando César Braga, Ariadne Duarte Lopes, Miriam Teresa Paz Takahashi, Jacqueline Aparecida Vieira Filho, Sidney Augusto |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Soares, Débora Barbosa da Silva Duarte, Lucienir Pains Cavalcanti, André Dias Silva, Fernando César Braga, Ariadne Duarte Lopes, Miriam Teresa Paz Takahashi, Jacqueline Aparecida Vieira Filho, Sidney Augusto |
dc.subject.por.fl_str_mv |
Rubiaceae |
topic |
Rubiaceae |
description |
The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-31T15:54:16Z 2017-08-31T15:54:16Z 2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017. 1678-2690 http://www.repositorio.ufop.br/handle/123456789/8637 |
identifier_str_mv |
SOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017. 1678-2690 |
url |
http://www.repositorio.ufop.br/handle/123456789/8637 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1813002833747771392 |