Psychotria viridis : chemical constituents from leaves and biological properties.

Detalhes bibliográficos
Autor(a) principal: Soares, Débora Barbosa da Silva
Data de Publicação: 2017
Outros Autores: Duarte, Lucienir Pains, Cavalcanti, André Dias, Silva, Fernando César, Braga, Ariadne Duarte, Lopes, Miriam Teresa Paz, Takahashi, Jacqueline Aparecida, Vieira Filho, Sidney Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/8637
Resumo: The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.
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spelling Psychotria viridis : chemical constituents from leaves and biological properties.RubiaceaeThe phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.2017-08-31T15:54:16Z2017-08-31T15:54:16Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017.1678-2690http://www.repositorio.ufop.br/handle/123456789/8637Os trabalhos publicados no periódico Anais da Academia Brasileira de Ciências, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Anais da Academia Brasileira de Ciências <http://www.scielo.br/scielo.php?script=sci_serial&pid=0001-3765&lng=en&nrm=iso>. Acesso em: 23 jan. 2020.info:eu-repo/semantics/openAccessSoares, Débora Barbosa da SilvaDuarte, Lucienir PainsCavalcanti, André DiasSilva, Fernando CésarBraga, Ariadne DuarteLopes, Miriam Teresa PazTakahashi, Jacqueline AparecidaVieira Filho, Sidney Augustoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-01-26T20:54:24Zoai:repositorio.ufop.br:123456789/8637Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-01-26T20:54:24Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Psychotria viridis : chemical constituents from leaves and biological properties.
title Psychotria viridis : chemical constituents from leaves and biological properties.
spellingShingle Psychotria viridis : chemical constituents from leaves and biological properties.
Soares, Débora Barbosa da Silva
Rubiaceae
title_short Psychotria viridis : chemical constituents from leaves and biological properties.
title_full Psychotria viridis : chemical constituents from leaves and biological properties.
title_fullStr Psychotria viridis : chemical constituents from leaves and biological properties.
title_full_unstemmed Psychotria viridis : chemical constituents from leaves and biological properties.
title_sort Psychotria viridis : chemical constituents from leaves and biological properties.
author Soares, Débora Barbosa da Silva
author_facet Soares, Débora Barbosa da Silva
Duarte, Lucienir Pains
Cavalcanti, André Dias
Silva, Fernando César
Braga, Ariadne Duarte
Lopes, Miriam Teresa Paz
Takahashi, Jacqueline Aparecida
Vieira Filho, Sidney Augusto
author_role author
author2 Duarte, Lucienir Pains
Cavalcanti, André Dias
Silva, Fernando César
Braga, Ariadne Duarte
Lopes, Miriam Teresa Paz
Takahashi, Jacqueline Aparecida
Vieira Filho, Sidney Augusto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Débora Barbosa da Silva
Duarte, Lucienir Pains
Cavalcanti, André Dias
Silva, Fernando César
Braga, Ariadne Duarte
Lopes, Miriam Teresa Paz
Takahashi, Jacqueline Aparecida
Vieira Filho, Sidney Augusto
dc.subject.por.fl_str_mv Rubiaceae
topic Rubiaceae
description The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β- sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-31T15:54:16Z
2017-08-31T15:54:16Z
2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017.
1678-2690
http://www.repositorio.ufop.br/handle/123456789/8637
identifier_str_mv SOARES, D. B. S. et al. Psychotria viridis: chemical constituents from leaves and biological properties. Anais da Academia Brasileira de Ciências, v. 89, p. 927-938, 2017. Disponível em: <http://www.scielo.br/scielo.php?pid=S0001-37652017000300927&script=sci_arttext>. Acesso em: 29 ago. 2017.
1678-2690
url http://www.repositorio.ufop.br/handle/123456789/8637
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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