Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.

Detalhes bibliográficos
Autor(a) principal: Cangussu, Luiza Michelle
Data de Publicação: 2009
Outros Autores: Castro, Uberdan Guilherme Mendes de, Machado, Raquel do Pilar, Silva, Marcelo Eustáquio, Ferreira, Patrícia Maria, Santos, Robson Augusto Souza dos, Santos, Maria José Campagnole dos, Alzamora, Andréia Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/1105
Resumo: In the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as observed in Sham rats. In both Sham and 2K1C, the hypotensive effect of Ang II and Ang-(1-7) at the CVLM was blocked, for up to 30 min, by previous CVLM microinjection of the Ang II AT 1 receptor antagonist, Losartan, and Ang-(1-7) Mas antagonist, A-779, respectively. As expected, the baroreflex bradycardia was lower in 2K1C in comparison to Sham rats. CVLM microinjection of A-779 improved the sensitivity of baroreflex bradycardia in 2K1C hypertensive rats. In contrast, Losartan had no effect on the baroreflex bradycardia in either 2K1C or Sham rats. These results suggest that Ang-(1-7) at the CVLM may contribute to the low sensitivity of the baroreflex control of heart rate in renovascular hypertensive rats
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spelling Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.Caudal ventrolateral medullaBaroreflex control of heart rateAngiotensin IIIn the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as observed in Sham rats. In both Sham and 2K1C, the hypotensive effect of Ang II and Ang-(1-7) at the CVLM was blocked, for up to 30 min, by previous CVLM microinjection of the Ang II AT 1 receptor antagonist, Losartan, and Ang-(1-7) Mas antagonist, A-779, respectively. As expected, the baroreflex bradycardia was lower in 2K1C in comparison to Sham rats. CVLM microinjection of A-779 improved the sensitivity of baroreflex bradycardia in 2K1C hypertensive rats. In contrast, Losartan had no effect on the baroreflex bradycardia in either 2K1C or Sham rats. These results suggest that Ang-(1-7) at the CVLM may contribute to the low sensitivity of the baroreflex control of heart rate in renovascular hypertensive rats2012-07-12T19:15:30Z2012-07-12T19:15:30Z2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCANGUSSU, L. M. et al. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, v. 30, n. 10, p. 1921-1927, out. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978109002666>. Acesso em: 12 jul. 2012.01969781http://www.repositorio.ufop.br/handle/123456789/1105O periódico Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3285361083380.info:eu-repo/semantics/openAccessCangussu, Luiza MichelleCastro, Uberdan Guilherme Mendes deMachado, Raquel do PilarSilva, Marcelo EustáquioFerreira, Patrícia MariaSantos, Robson Augusto Souza dosSantos, Maria José Campagnole dosAlzamora, Andréia Carvalhoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-02-27T14:22:32Zoai:repositorio.ufop.br:123456789/1105Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-27T14:22:32Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
title Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
spellingShingle Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
Cangussu, Luiza Michelle
Caudal ventrolateral medulla
Baroreflex control of heart rate
Angiotensin II
title_short Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
title_full Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
title_fullStr Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
title_full_unstemmed Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
title_sort Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia.
author Cangussu, Luiza Michelle
author_facet Cangussu, Luiza Michelle
Castro, Uberdan Guilherme Mendes de
Machado, Raquel do Pilar
Silva, Marcelo Eustáquio
Ferreira, Patrícia Maria
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
author_role author
author2 Castro, Uberdan Guilherme Mendes de
Machado, Raquel do Pilar
Silva, Marcelo Eustáquio
Ferreira, Patrícia Maria
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cangussu, Luiza Michelle
Castro, Uberdan Guilherme Mendes de
Machado, Raquel do Pilar
Silva, Marcelo Eustáquio
Ferreira, Patrícia Maria
Santos, Robson Augusto Souza dos
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
dc.subject.por.fl_str_mv Caudal ventrolateral medulla
Baroreflex control of heart rate
Angiotensin II
topic Caudal ventrolateral medulla
Baroreflex control of heart rate
Angiotensin II
description In the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as observed in Sham rats. In both Sham and 2K1C, the hypotensive effect of Ang II and Ang-(1-7) at the CVLM was blocked, for up to 30 min, by previous CVLM microinjection of the Ang II AT 1 receptor antagonist, Losartan, and Ang-(1-7) Mas antagonist, A-779, respectively. As expected, the baroreflex bradycardia was lower in 2K1C in comparison to Sham rats. CVLM microinjection of A-779 improved the sensitivity of baroreflex bradycardia in 2K1C hypertensive rats. In contrast, Losartan had no effect on the baroreflex bradycardia in either 2K1C or Sham rats. These results suggest that Ang-(1-7) at the CVLM may contribute to the low sensitivity of the baroreflex control of heart rate in renovascular hypertensive rats
publishDate 2009
dc.date.none.fl_str_mv 2009
2012-07-12T19:15:30Z
2012-07-12T19:15:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CANGUSSU, L. M. et al. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, v. 30, n. 10, p. 1921-1927, out. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978109002666>. Acesso em: 12 jul. 2012.
01969781
http://www.repositorio.ufop.br/handle/123456789/1105
identifier_str_mv CANGUSSU, L. M. et al. Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolateral medulla of renovascular hypertensive rats restores baroreflex bradycardia. Peptides, v. 30, n. 10, p. 1921-1927, out. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0196978109002666>. Acesso em: 12 jul. 2012.
01969781
url http://www.repositorio.ufop.br/handle/123456789/1105
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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