Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/1398 |
Resumo: | In order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively. |
id |
UFOP_5da558a0b533556e6e81c8ffd953b88f |
---|---|
oai_identifier_str |
oai:localhost:123456789/1398 |
network_acronym_str |
UFOP |
network_name_str |
Repositório Institucional da UFOP |
repository_id_str |
3233 |
spelling |
Silva, Neide MariaVieira, Júlio César MenezesCarneiro, Cláudia MartinsTafuri, Wagner Luiz2012-09-19T14:04:32Z2012-09-19T14:04:32Z2009SILVA, N. M. et al. Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Experimental Parasitology, v. 123, n. 1, p. 65-72, set. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489409001490>. Acesso em: 19 set. 2012.00144894http://www.repositorio.ufop.br/handle/123456789/1398In order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively.InflammationProtozoaToxoplasma gondiiToxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281420279890.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1398/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALARTIGO_ToxoplasmaGondiiRole.pdfARTIGO_ToxoplasmaGondiiRole.pdfapplication/pdf742269http://www.repositorio.ufop.br/bitstream/123456789/1398/1/ARTIGO_ToxoplasmaGondiiRole.pdfa64e6da782c0048c784ddee2b372adc4MD51123456789/13982019-03-08 11:11:38.332oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-08T16:11:38Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
title |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
spellingShingle |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Silva, Neide Maria Inflammation Protozoa Toxoplasma gondii |
title_short |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
title_full |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
title_fullStr |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
title_full_unstemmed |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
title_sort |
Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. |
author |
Silva, Neide Maria |
author_facet |
Silva, Neide Maria Vieira, Júlio César Menezes Carneiro, Cláudia Martins Tafuri, Wagner Luiz |
author_role |
author |
author2 |
Vieira, Júlio César Menezes Carneiro, Cláudia Martins Tafuri, Wagner Luiz |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Neide Maria Vieira, Júlio César Menezes Carneiro, Cláudia Martins Tafuri, Wagner Luiz |
dc.subject.por.fl_str_mv |
Inflammation Protozoa Toxoplasma gondii |
topic |
Inflammation Protozoa Toxoplasma gondii |
description |
In order to examine the role of IFN-c, TNFRp55 and iNOS in inflammatory reaction during toxoplasmosis, IFN-c_/_, TNFRp55_/_ and iNOS_/_ mice were experimentally infected with Toxoplasma gondii ME-49 strain. The organs of the mice were evaluated for histology and immunohistochemistry in detection of tissue parasitism and iNOS positive cells. IFN-c_/_ mice presented mild inflammation in peripheral organs associated with a high parasitism and mortality in the acute phase of infection. In contrast, the peripheral organs of WT, TNFRp55_/_ and iNOS_/_ mice, presented a significant inflammatory reaction and low tissue parasitism in the same period of infection. The inflammatory lesions and tissue parasitism were increased and more severe in the Central Nervous System (CNS) of TNFRp55_/_ and iNOS_/_ with a progression of infection, when compared to WT mice. In these knockout animals, the inflammatory changes were associated with low levels or no expression of iNOS in TNFRp55_/_ and iNOS_/_ mice, respectively. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2012-09-19T14:04:32Z |
dc.date.available.fl_str_mv |
2012-09-19T14:04:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, N. M. et al. Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Experimental Parasitology, v. 123, n. 1, p. 65-72, set. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489409001490>. Acesso em: 19 set. 2012. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/1398 |
dc.identifier.issn.none.fl_str_mv |
00144894 |
identifier_str_mv |
SILVA, N. M. et al. Toxoplasma gondii : the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection. Experimental Parasitology, v. 123, n. 1, p. 65-72, set. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489409001490>. Acesso em: 19 set. 2012. 00144894 |
url |
http://www.repositorio.ufop.br/handle/123456789/1398 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
bitstream.url.fl_str_mv |
http://www.repositorio.ufop.br/bitstream/123456789/1398/5/license.txt http://www.repositorio.ufop.br/bitstream/123456789/1398/1/ARTIGO_ToxoplasmaGondiiRole.pdf |
bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 a64e6da782c0048c784ddee2b372adc4 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1801685780798636032 |