Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits : chemical and biological assays.

• Autor(a) principal: Pinto, Isabelle Cristina
• Data de Publicação: 2020
• Outros Autores: Seibert, Janaína Brandão, Pinto, Luciano Silva, Santos, Vagner Rodrigues, Sousa, Rafaela F. de, Sousa, Lucas Resende Dutra, Amparo, Tatiane Roquete, Santos, Viviane Martins Rebello dos, Nascimento, Andréa Mendes do, Souza, Gustavo Henrique Bianco de, Vasconcellos, Walison Arthuso, Vieira, Paula Melo de Abreu, Andrade, Ângela Leão
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/14158; https://doi.org/10.1038/s41598-020-79257-3

Plants may contain benefcial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total refectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identifed by UPLC–QTOF–MS/MS. The release profle of favonoids and the mechanical properties of the GIC-BPE composite were assessed. The favonoids were released through a linear mechanism governing the difusion for the frst 48 h, as evidenced by the Mt √ /M∞ relatively to t, at a difusion coefcient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not difer signifcantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fbroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.