Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/959 |
Resumo: | The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total |
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Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.Canine visceral leishmaniasisParasite burdenImmunoglobulin avidityThe clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total2012-07-04T15:11:55Z2012-07-04T15:11:55Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfTEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012.03044017http://www.repositorio.ufop.br/handle/123456789/959O periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280860053397.info:eu-repo/semantics/openAccessTeixeira Neto, Rafael GonçalvesGiunchetti, Rodolfo CordeiroCarneiro, Cláudia MartinsVitor, Ricardo Wagner de AlmeidaVital, Wendel CouraQuaresma, Patrícia FláviaKer, Henrique GamaMelo, Lutiana Amaral deGontijo, Célia Maria FerreiraReis, Alexandre Barbosaengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-02-25T15:12:42Zoai:repositorio.ufop.br:123456789/959Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-25T15:12:42Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
title |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
spellingShingle |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Teixeira Neto, Rafael Gonçalves Canine visceral leishmaniasis Parasite burden Immunoglobulin avidity |
title_short |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
title_full |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
title_fullStr |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
title_full_unstemmed |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
title_sort |
Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. |
author |
Teixeira Neto, Rafael Gonçalves |
author_facet |
Teixeira Neto, Rafael Gonçalves Giunchetti, Rodolfo Cordeiro Carneiro, Cláudia Martins Vitor, Ricardo Wagner de Almeida Vital, Wendel Coura Quaresma, Patrícia Flávia Ker, Henrique Gama Melo, Lutiana Amaral de Gontijo, Célia Maria Ferreira Reis, Alexandre Barbosa |
author_role |
author |
author2 |
Giunchetti, Rodolfo Cordeiro Carneiro, Cláudia Martins Vitor, Ricardo Wagner de Almeida Vital, Wendel Coura Quaresma, Patrícia Flávia Ker, Henrique Gama Melo, Lutiana Amaral de Gontijo, Célia Maria Ferreira Reis, Alexandre Barbosa |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira Neto, Rafael Gonçalves Giunchetti, Rodolfo Cordeiro Carneiro, Cláudia Martins Vitor, Ricardo Wagner de Almeida Vital, Wendel Coura Quaresma, Patrícia Flávia Ker, Henrique Gama Melo, Lutiana Amaral de Gontijo, Célia Maria Ferreira Reis, Alexandre Barbosa |
dc.subject.por.fl_str_mv |
Canine visceral leishmaniasis Parasite burden Immunoglobulin avidity |
topic |
Canine visceral leishmaniasis Parasite burden Immunoglobulin avidity |
description |
The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2012-07-04T15:11:55Z 2012-07-04T15:11:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
TEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012. 03044017 http://www.repositorio.ufop.br/handle/123456789/959 |
identifier_str_mv |
TEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012. 03044017 |
url |
http://www.repositorio.ufop.br/handle/123456789/959 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1813002835068977152 |