Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.

Detalhes bibliográficos
Autor(a) principal: Teixeira Neto, Rafael Gonçalves
Data de Publicação: 2010
Outros Autores: Giunchetti, Rodolfo Cordeiro, Carneiro, Cláudia Martins, Vitor, Ricardo Wagner de Almeida, Vital, Wendel Coura, Quaresma, Patrícia Flávia, Ker, Henrique Gama, Melo, Lutiana Amaral de, Gontijo, Célia Maria Ferreira, Reis, Alexandre Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/959
Resumo: The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total
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spelling Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.Canine visceral leishmaniasisParasite burdenImmunoglobulin avidityThe clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total2012-07-04T15:11:55Z2012-07-04T15:11:55Z2010info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfTEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012.03044017http://www.repositorio.ufop.br/handle/123456789/959O periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280860053397.info:eu-repo/semantics/openAccessTeixeira Neto, Rafael GonçalvesGiunchetti, Rodolfo CordeiroCarneiro, Cláudia MartinsVitor, Ricardo Wagner de AlmeidaVital, Wendel CouraQuaresma, Patrícia FláviaKer, Henrique GamaMelo, Lutiana Amaral deGontijo, Célia Maria FerreiraReis, Alexandre Barbosaengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-02-25T15:12:42Zoai:repositorio.ufop.br:123456789/959Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-25T15:12:42Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
title Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
spellingShingle Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
Teixeira Neto, Rafael Gonçalves
Canine visceral leishmaniasis
Parasite burden
Immunoglobulin avidity
title_short Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
title_full Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
title_fullStr Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
title_full_unstemmed Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
title_sort Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis.
author Teixeira Neto, Rafael Gonçalves
author_facet Teixeira Neto, Rafael Gonçalves
Giunchetti, Rodolfo Cordeiro
Carneiro, Cláudia Martins
Vitor, Ricardo Wagner de Almeida
Vital, Wendel Coura
Quaresma, Patrícia Flávia
Ker, Henrique Gama
Melo, Lutiana Amaral de
Gontijo, Célia Maria Ferreira
Reis, Alexandre Barbosa
author_role author
author2 Giunchetti, Rodolfo Cordeiro
Carneiro, Cláudia Martins
Vitor, Ricardo Wagner de Almeida
Vital, Wendel Coura
Quaresma, Patrícia Flávia
Ker, Henrique Gama
Melo, Lutiana Amaral de
Gontijo, Célia Maria Ferreira
Reis, Alexandre Barbosa
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira Neto, Rafael Gonçalves
Giunchetti, Rodolfo Cordeiro
Carneiro, Cláudia Martins
Vitor, Ricardo Wagner de Almeida
Vital, Wendel Coura
Quaresma, Patrícia Flávia
Ker, Henrique Gama
Melo, Lutiana Amaral de
Gontijo, Célia Maria Ferreira
Reis, Alexandre Barbosa
dc.subject.por.fl_str_mv Canine visceral leishmaniasis
Parasite burden
Immunoglobulin avidity
topic Canine visceral leishmaniasis
Parasite burden
Immunoglobulin avidity
description The clinical status and tissue parasite burden of the skin and spleen of 40 dogs naturally infected with Leishmania chagasi (syn. Leishmania infantum), together with 5 uninfected control dogs, were assessed. On the basis of the clinical evaluation, infected dogs were classified as asymptomatic (AD) or symptomatic (SD). Infected animals were also grouped according to their parasite load as exhibiting low (LP), medium (MP) and high (HP) parasitism. The results indicated a high parasite load in the skin samples of SD animals in relation to the AD group. The serum immunoglobin isotype profiles of the studied animals revealed increased levels of IgG 1 in the AD and LP dogs, whereas high levels of IgG 2 were correlated with SD and HP dogs. The avidity index (AI) of IgG total in the SD group was high in comparison of that of the AD group. Moreover, animals with a larger parasite burden either in the spleen or skin showed higher AI values than animals with lower parasitism. Based on these findings, it is suggested that CVL commences with an asymptomatic clinical form with low parasitism, high production of IgG 1 and low affinity of IgG total molecules, and evolves into a symptomatic clinical form with higher parasitism intensity, higher IgG 2 levels, and high affinity of IgG total
publishDate 2010
dc.date.none.fl_str_mv 2010
2012-07-04T15:11:55Z
2012-07-04T15:11:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv TEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012.
03044017
http://www.repositorio.ufop.br/handle/123456789/959
identifier_str_mv TEIXEIRA NETO, R. G. T. et al. Relationship of Leishmania-specific IgG levels and IgG avidity with parasite density and clinical signs in canine leishmaniasis. Veterinary Parasitology, v. 169, n.1-2, p. 248-257, 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304401710000427>. Acesso em: 20 ago. 2012.
03044017
url http://www.repositorio.ufop.br/handle/123456789/959
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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