Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats.
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/4351 https://doi.org/10.1016/S0006-8993(97)00115-7 |
Resumo: | The Bezold-Jarisch _B-J. reflex was activated by serotonin _5-HT, i.v.. before and 10 min after bilateral microinjection of increasing doses of kynurenic acid, a non-selective antagonist of excitatory amino acid _EAA. receptors, into the commissural nucleus tractus solitarii _NTS. of sino-aortic deafferentated _SAD. and sham-operated _SO. unanesthetized rats. Increasing doses of kynurenic acid produced a dose-dependent blockade of the bradycardic and hypotensive responses to B-J reflex activation in both SO _from 0.1 to 10.0 nmolr100 nl. and SAD _from 0.1 to 2.0 nmolr100 nl.. Comparison of the effect of kynurenic acid on the hypotension and bradycardic dose–response curves showed a significant difference between SO and SAD rats, indicating that smaller doses of kynurenic acid are required in SAD rats than in SO rats to block the neurotransmission of the B-J reflex in the NTS. The data also showed that bilateral microinjection of kynurenic acid into the NTS at doses of 0.5 _131"7 vs. 115"8 mmHg. and 2.0 nmolr100 nl _140"11 vs. 116"9 mmHg. produced an acute and significant increase in the basal mean arterial pressure of SAD rats similar to that observed with the same doses in SO rats, which was back to control values 5–10 min later. The increase in basal mean arterial pressure immediately after kynurenic acid microinjection into the NTS of SAD rats suggests that in the absence of the arterial baroreceptors, the B-J reflex plays an important role in the autonomic regulation of the circulation. The data also show different dose–response curves for hypotension and bradycardia in response to B-J reflex activation in SAD than in SO rats in the presence of increasing doses of kynurenic acid into the NTS, indicating that the neurotransmission of the B-J reflex in the NTS of SAD rats is more sensitive to the blockade of the EAA receptors than in SO rats. |
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Chianca Júnior, Deoclécio AlvesBonagamba, Leni Gomes HeckMachado, Benedito Honório2015-01-22T15:13:44Z2015-01-22T15:13:44Z1997CHIANCA JÚNIOR, D. A.; BONAGAMBA, L. G. H.; MACHADO, B. H. Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. Brain Research , v. 756, n.01, p. 46-51, 1997. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0006899397001157>. Acesso em: 08 nov. 2014.0006-8993http://www.repositorio.ufop.br/handle/123456789/4351https://doi.org/10.1016/S0006-8993(97)00115-7The Bezold-Jarisch _B-J. reflex was activated by serotonin _5-HT, i.v.. before and 10 min after bilateral microinjection of increasing doses of kynurenic acid, a non-selective antagonist of excitatory amino acid _EAA. receptors, into the commissural nucleus tractus solitarii _NTS. of sino-aortic deafferentated _SAD. and sham-operated _SO. unanesthetized rats. Increasing doses of kynurenic acid produced a dose-dependent blockade of the bradycardic and hypotensive responses to B-J reflex activation in both SO _from 0.1 to 10.0 nmolr100 nl. and SAD _from 0.1 to 2.0 nmolr100 nl.. Comparison of the effect of kynurenic acid on the hypotension and bradycardic dose–response curves showed a significant difference between SO and SAD rats, indicating that smaller doses of kynurenic acid are required in SAD rats than in SO rats to block the neurotransmission of the B-J reflex in the NTS. The data also showed that bilateral microinjection of kynurenic acid into the NTS at doses of 0.5 _131"7 vs. 115"8 mmHg. and 2.0 nmolr100 nl _140"11 vs. 116"9 mmHg. produced an acute and significant increase in the basal mean arterial pressure of SAD rats similar to that observed with the same doses in SO rats, which was back to control values 5–10 min later. The increase in basal mean arterial pressure immediately after kynurenic acid microinjection into the NTS of SAD rats suggests that in the absence of the arterial baroreceptors, the B-J reflex plays an important role in the autonomic regulation of the circulation. The data also show different dose–response curves for hypotension and bradycardia in response to B-J reflex activation in SAD than in SO rats in the presence of increasing doses of kynurenic acid into the NTS, indicating that the neurotransmission of the B-J reflex in the NTS of SAD rats is more sensitive to the blockade of the EAA receptors than in SO rats.Afferent C-fiberCardiopulmonary receptorExcitatory amino acid receptorNeurogenic hypertensionNeurotransmissionNeurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Brain Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314361480357.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/4351/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_NeurotransmissionBenzoldJarisch.pdfARTIGO_NeurotransmissionBenzoldJarisch.pdfapplication/pdf217038http://www.repositorio.ufop.br/bitstream/123456789/4351/1/ARTIGO_NeurotransmissionBenzoldJarisch.pdf70bf3447c146b36d7e495934eef7fee5MD51123456789/43512019-06-12 11:34:41.908oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-06-12T15:34:41Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
title |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
spellingShingle |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. Chianca Júnior, Deoclécio Alves Afferent C-fiber Cardiopulmonary receptor Excitatory amino acid receptor Neurogenic hypertension Neurotransmission |
title_short |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
title_full |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
title_fullStr |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
title_full_unstemmed |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
title_sort |
Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. |
author |
Chianca Júnior, Deoclécio Alves |
author_facet |
Chianca Júnior, Deoclécio Alves Bonagamba, Leni Gomes Heck Machado, Benedito Honório |
author_role |
author |
author2 |
Bonagamba, Leni Gomes Heck Machado, Benedito Honório |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Chianca Júnior, Deoclécio Alves Bonagamba, Leni Gomes Heck Machado, Benedito Honório |
dc.subject.por.fl_str_mv |
Afferent C-fiber Cardiopulmonary receptor Excitatory amino acid receptor Neurogenic hypertension Neurotransmission |
topic |
Afferent C-fiber Cardiopulmonary receptor Excitatory amino acid receptor Neurogenic hypertension Neurotransmission |
description |
The Bezold-Jarisch _B-J. reflex was activated by serotonin _5-HT, i.v.. before and 10 min after bilateral microinjection of increasing doses of kynurenic acid, a non-selective antagonist of excitatory amino acid _EAA. receptors, into the commissural nucleus tractus solitarii _NTS. of sino-aortic deafferentated _SAD. and sham-operated _SO. unanesthetized rats. Increasing doses of kynurenic acid produced a dose-dependent blockade of the bradycardic and hypotensive responses to B-J reflex activation in both SO _from 0.1 to 10.0 nmolr100 nl. and SAD _from 0.1 to 2.0 nmolr100 nl.. Comparison of the effect of kynurenic acid on the hypotension and bradycardic dose–response curves showed a significant difference between SO and SAD rats, indicating that smaller doses of kynurenic acid are required in SAD rats than in SO rats to block the neurotransmission of the B-J reflex in the NTS. The data also showed that bilateral microinjection of kynurenic acid into the NTS at doses of 0.5 _131"7 vs. 115"8 mmHg. and 2.0 nmolr100 nl _140"11 vs. 116"9 mmHg. produced an acute and significant increase in the basal mean arterial pressure of SAD rats similar to that observed with the same doses in SO rats, which was back to control values 5–10 min later. The increase in basal mean arterial pressure immediately after kynurenic acid microinjection into the NTS of SAD rats suggests that in the absence of the arterial baroreceptors, the B-J reflex plays an important role in the autonomic regulation of the circulation. The data also show different dose–response curves for hypotension and bradycardia in response to B-J reflex activation in SAD than in SO rats in the presence of increasing doses of kynurenic acid into the NTS, indicating that the neurotransmission of the B-J reflex in the NTS of SAD rats is more sensitive to the blockade of the EAA receptors than in SO rats. |
publishDate |
1997 |
dc.date.issued.fl_str_mv |
1997 |
dc.date.accessioned.fl_str_mv |
2015-01-22T15:13:44Z |
dc.date.available.fl_str_mv |
2015-01-22T15:13:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CHIANCA JÚNIOR, D. A.; BONAGAMBA, L. G. H.; MACHADO, B. H. Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. Brain Research , v. 756, n.01, p. 46-51, 1997. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0006899397001157>. Acesso em: 08 nov. 2014. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/4351 |
dc.identifier.issn.none.fl_str_mv |
0006-8993 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/S0006-8993(97)00115-7 |
identifier_str_mv |
CHIANCA JÚNIOR, D. A.; BONAGAMBA, L. G. H.; MACHADO, B. H. Neurotransmission of the Bezold-Jarisch reflex in the nucleus tractus solitarii of sino-aortic deafferentated rats. Brain Research , v. 756, n.01, p. 46-51, 1997. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0006899397001157>. Acesso em: 08 nov. 2014. 0006-8993 |
url |
http://www.repositorio.ufop.br/handle/123456789/4351 https://doi.org/10.1016/S0006-8993(97)00115-7 |
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