Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.

• Autor(a) principal: Benedicto, Augusto Vieira Lima
• Data de Publicação: 2016
• Outros Autores: Correa, Rodrigo de Souza, Graminha, Angelica Ellen, Kuznetsov, Aleksey Evgenyevich, Ellena, Javier Alcides, Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Batista, Alzir Azevedo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/7066; http://dx.doi.org/10.5935/0103-5053.20150237
• topic: Ruthenium complexes; Pyrimidine-2-thiolate; Diphosphine ligand; Cytotoxity - tuberculosis

The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA.