Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults.

• Autor(a) principal: Volp, Ana Carolina Pinheiro
• Data de Publicação: 2012
• Outros Autores: Barbosa, Kiriaque Barra Ferreira, Bressan, Josefina
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/2120
• topic: Inflammation; Triacylglycerols; Metabolic syndrome; Body composition; Obesity

Objective: To evaluate the association between serum concentrations of complement factor-3 (C3) with anthropometric, biochemical, and lifestyle features in healthyyoungadults. Methods: From 157 younghealthyadults 18 to 35 y old, anthropometric measurements and body composition, systolic and diastolic blood pressures, and lifestyle data were collected and analyzed. Blood samples were collected after a 12-h fast for the determination of glucose, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, insulin, C3, ceruloplasmin, and uric acid. Results: Complement factor-3 correlated directly with bodymass index (r = 0.23417, P = 0.0032), bodyfatmass (bioelectrical impedance analysis; r = 0.33407, P < 0.0001), percentage of bodyfat (bioelectrical impedance analysis; r = 0.26873, P = 0.0007), waist circumference (r = 0.21266, P = 0.0075), insulin (r = 0.26152, P = 0.0009), homeostasis model assessment of insulin resistance (r = 0.24831, P = 0.0017), total cholesterol (r = 0.23335, P = 0.0033), triacylglycerols (r = 0.38435, P < 0.0001), and other outcome measurements. In the multiple linear regression analysis, triacylglycerols (r2 = 0.1379, P < 0.0001) and bodyfatmass (bioelectrical impedance analysis; r2 = 0.0621, P = 0.0010) were independently associated with the C3 concentration after adjusting for age, gender, smoking status, and physical activity. Conclusion: Complement factor-3 seems to be related to several anthropometric and biochemical measurements in healthyyoungadults. These results demonstrate an independent role of triacylglycerols, a component of the metabolic syndrome, and bodyfatmass as possiblepredictors of C3 concentrations. Thus, C3 can be used as an early marker for metabolic syndrome manifestations.