Analysis of liver fragment subjected to autologous transplant at rat’s retroperitoneum.

• Autor(a) principal: Diniz, Mirla Fiuza
• Data de Publicação: 2015
• Outros Autores: Siqueira, Sávio Lana, Baumfeld, Tiago Soares, Pereira, Luis Felipe Cintra, Moreira, Filipe Garcia, Ribeiro, Gustavo Meirelles, Souza, Iure Kalinine Ferraz de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/6676; https://doi.org/10.1016/j.jss.2015.06.029
• topic: Hepatic regeneration; Autotransplantation; Experimental surgery

Background: To investigate the regeneration process of autologous implants of liver on the retroperitoneum. Methods: Thirty male Fisher rats were used divided in to group 1 (G1): studied 60 d after surgery; group 2 (G2): studied 90 d after surgery; group 3 (G3): studied 180 d after surgery; and group C (GC): animals without surgery. Hepatic fragment was processed for histologic and biochemical analysis. Results: There was inflammatory infiltrate, diffuse hydropic degeneration, necrosis, and moderate fibrosis that reduced in direct relation to the postsurgical time. The concentration of albuminwas differentbetweenGCandG1 and betweenG1 andG3 (P¼0.0007).The Catalase (CAT) was related to the time of surgery with GC being different when compared with G1, G2, and G3 (P < 0.0001). The oxidative stress measured through the thiobarbituric acid reactive substances lipid peroxidation was different between the GC and the G2 groups (P ¼ 0.0381). Conclusions: The analysis made showed hepatic regeneration in the fragment subjected to autologous transplant at the retroperitoneum