Protective effects of quercetin on livers from mice exposed to long-term cigarette smoke.

• Autor(a) principal: Machado Júnior, Pedro Alves
• Data de Publicação: 2020
• Outros Autores: Araújo, Natália Pereira da Silva, Souza, Ana Beatriz Farias de, Castro, Thalles de Freitas, Oliveira, Michel Ângelo das Graças Silva, Costa, Guilherme de Paula, Matos, Natália Alves de, Vieira, Paula Melo de Abreu, Silva, André Talvani Pedrosa da, Bezerra, Frank Silva, Cangussú, Silvia Dantas
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/13786; https://doi.org/10.1155/2020/2196207

Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.