Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/9212 https://doi.org/10.1016/j.bj.2016.08.004 |
Resumo: | Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruction is still incomplete. In this review, we offer a new approach to the control of the immune response against the parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine either by directly acting on the levels of these molecules or by inducing the expression of CD39 and CD73 on the infected cell may influence the magnitude of the immune response against the parasite contributing to its growth and survival. |
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Figueiredo, Amanda Braga deTestasicca, Miriam Conceição de SouzaAfonso, Luís Carlos Crocco2017-11-29T15:05:20Z2017-11-29T15:05:20Z2016FIGUEIREDO, A. M.; TESTASICCA, M. C. de; AFONSO, L. C. C. Purinergic signaling and infection by Leishmania: a new approach to evasion of the immune response. Biomedical Journal, v. 39, p. 244-250, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S2319417016300385?via%3Dihub>. Acesso em: 15 set. 2017. 2319-4170http://www.repositorio.ufop.br/handle/123456789/9212https://doi.org/10.1016/j.bj.2016.08.004Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruction is still incomplete. In this review, we offer a new approach to the control of the immune response against the parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine either by directly acting on the levels of these molecules or by inducing the expression of CD39 and CD73 on the infected cell may influence the magnitude of the immune response against the parasite contributing to its growth and survival.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Fonte: o próprio artigo.info:eu-repo/semantics/openAccessInnate responseImmune evasionPurinergic signalingPurinergic signaling and infection by Leishmania : a new approach to evasion of the immune response.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9212/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_PurinergicSingnalingInfection.pdfARTIGO_PurinergicSingnalingInfection.pdfapplication/pdf379497http://www.repositorio.ufop.br/bitstream/123456789/9212/1/ARTIGO_PurinergicSingnalingInfection.pdfbc5d15561dde2c918cadf258c3aa2867MD51123456789/92122020-02-20 09:11:31.951oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-02-20T14:11:31Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
title |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
spellingShingle |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. Figueiredo, Amanda Braga de Innate response Immune evasion Purinergic signaling |
title_short |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
title_full |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
title_fullStr |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
title_full_unstemmed |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
title_sort |
Purinergic signaling and infection by Leishmania : a new approach to evasion of the immune response. |
author |
Figueiredo, Amanda Braga de |
author_facet |
Figueiredo, Amanda Braga de Testasicca, Miriam Conceição de Souza Afonso, Luís Carlos Crocco |
author_role |
author |
author2 |
Testasicca, Miriam Conceição de Souza Afonso, Luís Carlos Crocco |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Figueiredo, Amanda Braga de Testasicca, Miriam Conceição de Souza Afonso, Luís Carlos Crocco |
dc.subject.por.fl_str_mv |
Innate response Immune evasion Purinergic signaling |
topic |
Innate response Immune evasion Purinergic signaling |
description |
Infection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruction is still incomplete. In this review, we offer a new approach to the control of the immune response against the parasite. The ability of the parasite to modulate the levels of extracellular ATP and adenosine either by directly acting on the levels of these molecules or by inducing the expression of CD39 and CD73 on the infected cell may influence the magnitude of the immune response against the parasite contributing to its growth and survival. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-11-29T15:05:20Z |
dc.date.available.fl_str_mv |
2017-11-29T15:05:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FIGUEIREDO, A. M.; TESTASICCA, M. C. de; AFONSO, L. C. C. Purinergic signaling and infection by Leishmania: a new approach to evasion of the immune response. Biomedical Journal, v. 39, p. 244-250, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S2319417016300385?via%3Dihub>. Acesso em: 15 set. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/9212 |
dc.identifier.issn.none.fl_str_mv |
2319-4170 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.bj.2016.08.004 |
identifier_str_mv |
FIGUEIREDO, A. M.; TESTASICCA, M. C. de; AFONSO, L. C. C. Purinergic signaling and infection by Leishmania: a new approach to evasion of the immune response. Biomedical Journal, v. 39, p. 244-250, 2016. Disponível em: <http://www.sciencedirect.com/science/article/pii/S2319417016300385?via%3Dihub>. Acesso em: 15 set. 2017. 2319-4170 |
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http://www.repositorio.ufop.br/handle/123456789/9212 https://doi.org/10.1016/j.bj.2016.08.004 |
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