Hematological alterations during experimental canine infection by Trypanosoma cruzi.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFOP |
| Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/6016 http://dx.doi.org/10.1590/S1984-29612012000200015 |
Resumo: | Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T. cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas. |
| id |
UFOP_c8d5765d41c2dba8d58e27ee9ec445e5 |
|---|---|
| oai_identifier_str |
oai:localhost:123456789/6016 |
| network_acronym_str |
UFOP |
| network_name_str |
Repositório Institucional da UFOP |
| repository_id_str |
3233 |
| spelling |
Guedes, Paulo Marcos da MattaVeloso, Vanja MariaMineo, Tiago Wilson PatriarcaSilva, Juliana SantiagoCrepalde, Geovam PereiraCaldas, Ivo SantanaNascimento, Manuela Sales LimaLana, Marta deChiari, EglerGalvão, Lúcia Maria da CunhaBahia, Maria Terezinha2016-01-12T17:05:48Z2016-01-12T17:05:48Z2012GUEDES, P. M. M. et al. Hematological alterations during experimental canine infection by Trypanosoma cruzi. Revista Brasileira de Parasitologia Veterinária, v. 21, n. 2, p. 151-156, 2012. Dispoinível em: <http://www.scielo.br/pdf/rbpv/v21n2/v21n2a15.pdf>. Acesso em: 21 out. 2015.1984-2961http://www.repositorio.ufop.br/handle/123456789/6016http://dx.doi.org/10.1590/S1984-29612012000200015Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T. cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas.To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosoma cruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Simultaneously, we observed anemia, leukocytosis and lymphocytosis. Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T. cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease.Trypanosoma cruziBeagle dogsParasitemiaLymphocytosisHematological alterations during experimental canine infection by Trypanosoma cruzi.Alterações hematológicas durante a infecção canina experimental por Trypanosoma cruzi.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTodo o conteúdo do periódico Revista Brasileira de Parasitologia Veterinária, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Revista Brasileira de Parasitologia Veterinária <http://www.scielo.br/scielo.php?script=sci_serial&pid=1984-2961&lng=en&nrm=iso>. Acesso em: 19 jan. 2017.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/6016/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_HematologicalAlterationsDuring.pdfARTIGO_HematologicalAlterationsDuring.pdfapplication/pdf589414http://www.repositorio.ufop.br/bitstream/123456789/6016/1/ARTIGO_HematologicalAlterationsDuring.pdf01db013b649275ff457570ca560ec67cMD51123456789/60162019-08-23 14:15:42.076oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-08-23T18:15:42Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
| dc.title.pt_BR.fl_str_mv |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| dc.title.alternative.pt_BR.fl_str_mv |
Alterações hematológicas durante a infecção canina experimental por Trypanosoma cruzi. |
| title |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| spellingShingle |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. Guedes, Paulo Marcos da Matta Trypanosoma cruzi Beagle dogs Parasitemia Lymphocytosis |
| title_short |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| title_full |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| title_fullStr |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| title_full_unstemmed |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| title_sort |
Hematological alterations during experimental canine infection by Trypanosoma cruzi. |
| author |
Guedes, Paulo Marcos da Matta |
| author_facet |
Guedes, Paulo Marcos da Matta Veloso, Vanja Maria Mineo, Tiago Wilson Patriarca Silva, Juliana Santiago Crepalde, Geovam Pereira Caldas, Ivo Santana Nascimento, Manuela Sales Lima Lana, Marta de Chiari, Egler Galvão, Lúcia Maria da Cunha Bahia, Maria Terezinha |
| author_role |
author |
| author2 |
Veloso, Vanja Maria Mineo, Tiago Wilson Patriarca Silva, Juliana Santiago Crepalde, Geovam Pereira Caldas, Ivo Santana Nascimento, Manuela Sales Lima Lana, Marta de Chiari, Egler Galvão, Lúcia Maria da Cunha Bahia, Maria Terezinha |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Guedes, Paulo Marcos da Matta Veloso, Vanja Maria Mineo, Tiago Wilson Patriarca Silva, Juliana Santiago Crepalde, Geovam Pereira Caldas, Ivo Santana Nascimento, Manuela Sales Lima Lana, Marta de Chiari, Egler Galvão, Lúcia Maria da Cunha Bahia, Maria Terezinha |
| dc.subject.por.fl_str_mv |
Trypanosoma cruzi Beagle dogs Parasitemia Lymphocytosis |
| topic |
Trypanosoma cruzi Beagle dogs Parasitemia Lymphocytosis |
| description |
Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, observou-se anemia, leucocitose e linfocitose. Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T. cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas. |
| publishDate |
2012 |
| dc.date.issued.fl_str_mv |
2012 |
| dc.date.accessioned.fl_str_mv |
2016-01-12T17:05:48Z |
| dc.date.available.fl_str_mv |
2016-01-12T17:05:48Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
GUEDES, P. M. M. et al. Hematological alterations during experimental canine infection by Trypanosoma cruzi. Revista Brasileira de Parasitologia Veterinária, v. 21, n. 2, p. 151-156, 2012. Dispoinível em: <http://www.scielo.br/pdf/rbpv/v21n2/v21n2a15.pdf>. Acesso em: 21 out. 2015. |
| dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/6016 |
| dc.identifier.issn.none.fl_str_mv |
1984-2961 |
| dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S1984-29612012000200015 |
| identifier_str_mv |
GUEDES, P. M. M. et al. Hematological alterations during experimental canine infection by Trypanosoma cruzi. Revista Brasileira de Parasitologia Veterinária, v. 21, n. 2, p. 151-156, 2012. Dispoinível em: <http://www.scielo.br/pdf/rbpv/v21n2/v21n2a15.pdf>. Acesso em: 21 out. 2015. 1984-2961 |
| url |
http://www.repositorio.ufop.br/handle/123456789/6016 http://dx.doi.org/10.1590/S1984-29612012000200015 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| instname_str |
Universidade Federal de Ouro Preto (UFOP) |
| instacron_str |
UFOP |
| institution |
UFOP |
| reponame_str |
Repositório Institucional da UFOP |
| collection |
Repositório Institucional da UFOP |
| bitstream.url.fl_str_mv |
http://www.repositorio.ufop.br/bitstream/123456789/6016/2/license.txt http://www.repositorio.ufop.br/bitstream/123456789/6016/1/ARTIGO_HematologicalAlterationsDuring.pdf |
| bitstream.checksum.fl_str_mv |
c2ffdd99e58acf69202dff00d361f23a 01db013b649275ff457570ca560ec67c |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
| repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
| _version_ |
1801685757749886976 |