Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.

Detalhes bibliográficos
Autor(a) principal: Amaral, Ricardo Guimarães
Data de Publicação: 2020
Outros Autores: Gomes, Silvana Vieira Floresta, Andrade, Luciana Nalone, Santos, Sara Albuquerque dos, Severino, Patrícia, Albuquerque Júnior, Ricardo Luiz Cavalcanti de, Souto, Eliana B., Brandão, Geraldo Célio, Santos, Sandra Lauton, David, Jorge Mauricio, Carvalho, Adriana Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/14092
https://doi.org/10.3390/molecules25204814
Resumo: Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.
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spelling Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.Natural productsCancerPassiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.2021-12-06T19:04:21Z2021-12-06T19:04:21Z2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAMARAL, R. G. et al. Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract. Molecules, v. 25, p. 4814, 2020. Disponível em: <https://www.mdpi.com/1420-3049/25/20/4814>. Acesso em: 10 jun. 2021.1420-3049http://www.repositorio.ufop.br/jspui/handle/123456789/14092https://doi.org/10.3390/molecules25204814This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Fonte: o PDF do artigo.info:eu-repo/semantics/openAccessAmaral, Ricardo GuimarãesGomes, Silvana Vieira FlorestaAndrade, Luciana NaloneSantos, Sara Albuquerque dosSeverino, PatríciaAlbuquerque Júnior, Ricardo Luiz Cavalcanti deSouto, Eliana B.Brandão, Geraldo CélioSantos, Sandra LautonDavid, Jorge MauricioCarvalho, Adriana Andradeengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2021-12-06T19:04:29Zoai:repositorio.ufop.br:123456789/14092Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332021-12-06T19:04:29Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
title Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
spellingShingle Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
Amaral, Ricardo Guimarães
Natural products
Cancer
title_short Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
title_full Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
title_fullStr Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
title_full_unstemmed Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
title_sort Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
author Amaral, Ricardo Guimarães
author_facet Amaral, Ricardo Guimarães
Gomes, Silvana Vieira Floresta
Andrade, Luciana Nalone
Santos, Sara Albuquerque dos
Severino, Patrícia
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Souto, Eliana B.
Brandão, Geraldo Célio
Santos, Sandra Lauton
David, Jorge Mauricio
Carvalho, Adriana Andrade
author_role author
author2 Gomes, Silvana Vieira Floresta
Andrade, Luciana Nalone
Santos, Sara Albuquerque dos
Severino, Patrícia
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Souto, Eliana B.
Brandão, Geraldo Célio
Santos, Sandra Lauton
David, Jorge Mauricio
Carvalho, Adriana Andrade
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amaral, Ricardo Guimarães
Gomes, Silvana Vieira Floresta
Andrade, Luciana Nalone
Santos, Sara Albuquerque dos
Severino, Patrícia
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Souto, Eliana B.
Brandão, Geraldo Célio
Santos, Sandra Lauton
David, Jorge Mauricio
Carvalho, Adriana Andrade
dc.subject.por.fl_str_mv Natural products
Cancer
topic Natural products
Cancer
description Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021-12-06T19:04:21Z
2021-12-06T19:04:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv AMARAL, R. G. et al. Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract. Molecules, v. 25, p. 4814, 2020. Disponível em: <https://www.mdpi.com/1420-3049/25/20/4814>. Acesso em: 10 jun. 2021.
1420-3049
http://www.repositorio.ufop.br/jspui/handle/123456789/14092
https://doi.org/10.3390/molecules25204814
identifier_str_mv AMARAL, R. G. et al. Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract. Molecules, v. 25, p. 4814, 2020. Disponível em: <https://www.mdpi.com/1420-3049/25/20/4814>. Acesso em: 10 jun. 2021.
1420-3049
url http://www.repositorio.ufop.br/jspui/handle/123456789/14092
https://doi.org/10.3390/molecules25204814
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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