Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion.
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/11512 http://dx.doi.org/10.21577/0100-4042.20170345 |
Resumo: | Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations. |
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Gonçalves, Marlucy da CruzSantos, Viviane Martins Rebello dosTaylor, Jason GuyPerasoli, Fernanda BarçanteSantos, Orlando David Henrique dosRabelo, Ana Carolina SilveiraRossoni Junior, Joamyr VictorCosta, Daniela CaldeiraCazati, Thiago2019-06-10T14:06:13Z2019-06-10T14:06:13Z2019GOLÇALVES, M. da C. Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. Quimica Nova, v. 42, n. 4, p. 365-370, 2019. Disponível em: <http://quimicanova.sbq.org.br/imagebank/pdf/AR20180381.pdf>. Acesso em: 19 mar. 2019.1678-7064http://www.repositorio.ufop.br/handle/123456789/11512http://dx.doi.org/10.21577/0100-4042.20170345Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations.This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessSun protection factorSunscreenPhoto protectionOrganic synthesisQuercetinPreparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/11512/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_PreparationCharacterizationQuercetin-Tetraethyl.pdfARTIGO_PreparationCharacterizationQuercetin-Tetraethyl.pdfapplication/pdf1129532http://www.repositorio.ufop.br/bitstream/123456789/11512/1/ARTIGO_PreparationCharacterizationQuercetin-Tetraethyl.pdff4f94ad2bd87d239ec92d421f051e251MD51123456789/115122019-06-10 10:06:13.257oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-06-10T14:06:13Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
title |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
spellingShingle |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. Gonçalves, Marlucy da Cruz Sun protection factor Sunscreen Photo protection Organic synthesis Quercetin |
title_short |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
title_full |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
title_fullStr |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
title_full_unstemmed |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
title_sort |
Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. |
author |
Gonçalves, Marlucy da Cruz |
author_facet |
Gonçalves, Marlucy da Cruz Santos, Viviane Martins Rebello dos Taylor, Jason Guy Perasoli, Fernanda Barçante Santos, Orlando David Henrique dos Rabelo, Ana Carolina Silveira Rossoni Junior, Joamyr Victor Costa, Daniela Caldeira Cazati, Thiago |
author_role |
author |
author2 |
Santos, Viviane Martins Rebello dos Taylor, Jason Guy Perasoli, Fernanda Barçante Santos, Orlando David Henrique dos Rabelo, Ana Carolina Silveira Rossoni Junior, Joamyr Victor Costa, Daniela Caldeira Cazati, Thiago |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gonçalves, Marlucy da Cruz Santos, Viviane Martins Rebello dos Taylor, Jason Guy Perasoli, Fernanda Barçante Santos, Orlando David Henrique dos Rabelo, Ana Carolina Silveira Rossoni Junior, Joamyr Victor Costa, Daniela Caldeira Cazati, Thiago |
dc.subject.por.fl_str_mv |
Sun protection factor Sunscreen Photo protection Organic synthesis Quercetin |
topic |
Sun protection factor Sunscreen Photo protection Organic synthesis Quercetin |
description |
Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-06-10T14:06:13Z |
dc.date.available.fl_str_mv |
2019-06-10T14:06:13Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOLÇALVES, M. da C. Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. Quimica Nova, v. 42, n. 4, p. 365-370, 2019. Disponível em: <http://quimicanova.sbq.org.br/imagebank/pdf/AR20180381.pdf>. Acesso em: 19 mar. 2019. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/11512 |
dc.identifier.issn.none.fl_str_mv |
1678-7064 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.21577/0100-4042.20170345 |
identifier_str_mv |
GOLÇALVES, M. da C. Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion. Quimica Nova, v. 42, n. 4, p. 365-370, 2019. Disponível em: <http://quimicanova.sbq.org.br/imagebank/pdf/AR20180381.pdf>. Acesso em: 19 mar. 2019. 1678-7064 |
url |
http://www.repositorio.ufop.br/handle/123456789/11512 http://dx.doi.org/10.21577/0100-4042.20170345 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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Universidade Federal de Ouro Preto (UFOP) |
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UFOP |
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UFOP |
reponame_str |
Repositório Institucional da UFOP |
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Repositório Institucional da UFOP |
bitstream.url.fl_str_mv |
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