Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/6076 https://doi.org/10.1016/j.vetpar.2014.08.022 |
Resumo: | Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukin |
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Leal, Gleisiane Gomes de AlmeidaRoatt, Bruno MendesSoares, Rodrigo Dian de Oliveira AguiarCarneiro, Cláudia MartinsGiunchetti, Rodolfo CordeiroCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisFrancisco, Amanda FortesCardoso, Jamille Mirelle de OliveiraMathias, Fernando Augusto SiqueiraOliveira, Rodrigo Corrêa deCarneiro, MariângelaVital, Wendel CouraReis, Alexandre Barbosa2016-01-15T16:44:45Z2016-01-15T16:44:45Z2014LEAL, G. G. de A. et al. Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Veterinary Parasitology, v. 205, p. 472-482, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304401714004762>. Acesso em: 15 out. 2015.0304-4017http://www.repositorio.ufop.br/handle/123456789/6076https://doi.org/10.1016/j.vetpar.2014.08.022Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukinImmunophenotypingCytokinesCanine visceral leishmaniasisImmunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Veterinary Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3732990764611.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/6076/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_ImmunologicalProfileResistance.pdfARTIGO_ImmunologicalProfileResistance.pdfapplication/pdf479109http://www.repositorio.ufop.br/bitstream/123456789/6076/1/ARTIGO_ImmunologicalProfileResistance.pdf313a36d0bbb0775d269b879a78ed8071MD51123456789/60762019-08-26 12:51:22.099oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-08-26T16:51:22Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
title |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
spellingShingle |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Leal, Gleisiane Gomes de Almeida Immunophenotyping Cytokines Canine visceral leishmaniasis |
title_short |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
title_full |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
title_fullStr |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
title_full_unstemmed |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
title_sort |
Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. |
author |
Leal, Gleisiane Gomes de Almeida |
author_facet |
Leal, Gleisiane Gomes de Almeida Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Carneiro, Cláudia Martins Giunchetti, Rodolfo Cordeiro Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Francisco, Amanda Fortes Cardoso, Jamille Mirelle de Oliveira Mathias, Fernando Augusto Siqueira Oliveira, Rodrigo Corrêa de Carneiro, Mariângela Vital, Wendel Coura Reis, Alexandre Barbosa |
author_role |
author |
author2 |
Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Carneiro, Cláudia Martins Giunchetti, Rodolfo Cordeiro Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Francisco, Amanda Fortes Cardoso, Jamille Mirelle de Oliveira Mathias, Fernando Augusto Siqueira Oliveira, Rodrigo Corrêa de Carneiro, Mariângela Vital, Wendel Coura Reis, Alexandre Barbosa |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Leal, Gleisiane Gomes de Almeida Roatt, Bruno Mendes Soares, Rodrigo Dian de Oliveira Aguiar Carneiro, Cláudia Martins Giunchetti, Rodolfo Cordeiro Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Francisco, Amanda Fortes Cardoso, Jamille Mirelle de Oliveira Mathias, Fernando Augusto Siqueira Oliveira, Rodrigo Corrêa de Carneiro, Mariângela Vital, Wendel Coura Reis, Alexandre Barbosa |
dc.subject.por.fl_str_mv |
Immunophenotyping Cytokines Canine visceral leishmaniasis |
topic |
Immunophenotyping Cytokines Canine visceral leishmaniasis |
description |
Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukin |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2016-01-15T16:44:45Z |
dc.date.available.fl_str_mv |
2016-01-15T16:44:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LEAL, G. G. de A. et al. Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Veterinary Parasitology, v. 205, p. 472-482, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304401714004762>. Acesso em: 15 out. 2015. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/6076 |
dc.identifier.issn.none.fl_str_mv |
0304-4017 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.vetpar.2014.08.022 |
identifier_str_mv |
LEAL, G. G. de A. et al. Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum. Veterinary Parasitology, v. 205, p. 472-482, 2014. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0304401714004762>. Acesso em: 15 out. 2015. 0304-4017 |
url |
http://www.repositorio.ufop.br/handle/123456789/6076 https://doi.org/10.1016/j.vetpar.2014.08.022 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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