Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.

Detalhes bibliográficos
Autor(a) principal: Maksud, Fabiana Alves Nunes
Data de Publicação: 2017
Outros Autores: Kakehasi, Adriana Maria, Guimarães, M. F. B. R., Machado, Carla Jorge, Barbosa, Alfredo José Afonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/8773
http://dx.doi.org/10.1590/1414-431x20175977
Resumo: Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.
id UFOP_e2e27c49a903e4fea9807a2b01290ada
oai_identifier_str oai:repositorio.ufop.br:123456789/8773
network_acronym_str UFOP
network_name_str Repositório Institucional da UFOP
repository_id_str 3233
spelling Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.Gastric mucosaBone metabolismOsteoporosisRheumatoid arthritisGeneralized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.2017-09-22T12:48:47Z2017-09-22T12:48:47Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.1414-431Xhttp://www.repositorio.ufop.br/handle/123456789/8773http://dx.doi.org/10.1590/1414-431x20175977Os trabalhos publicados no periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, estão sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 31 jan. 2020.info:eu-repo/semantics/openAccessMaksud, Fabiana Alves NunesKakehasi, Adriana MariaGuimarães, M. F. B. R.Machado, Carla JorgeBarbosa, Alfredo José Afonsoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2020-01-31T12:00:50Zoai:repositorio.ufop.br:123456789/8773Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-01-31T12:00:50Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
title Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
spellingShingle Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
Maksud, Fabiana Alves Nunes
Gastric mucosa
Bone metabolism
Osteoporosis
Rheumatoid arthritis
title_short Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
title_full Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
title_fullStr Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
title_full_unstemmed Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
title_sort Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
author Maksud, Fabiana Alves Nunes
author_facet Maksud, Fabiana Alves Nunes
Kakehasi, Adriana Maria
Guimarães, M. F. B. R.
Machado, Carla Jorge
Barbosa, Alfredo José Afonso
author_role author
author2 Kakehasi, Adriana Maria
Guimarães, M. F. B. R.
Machado, Carla Jorge
Barbosa, Alfredo José Afonso
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maksud, Fabiana Alves Nunes
Kakehasi, Adriana Maria
Guimarães, M. F. B. R.
Machado, Carla Jorge
Barbosa, Alfredo José Afonso
dc.subject.por.fl_str_mv Gastric mucosa
Bone metabolism
Osteoporosis
Rheumatoid arthritis
topic Gastric mucosa
Bone metabolism
Osteoporosis
Rheumatoid arthritis
description Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-22T12:48:47Z
2017-09-22T12:48:47Z
2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.
1414-431X
http://www.repositorio.ufop.br/handle/123456789/8773
http://dx.doi.org/10.1590/1414-431x20175977
identifier_str_mv MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.
1414-431X
url http://www.repositorio.ufop.br/handle/123456789/8773
http://dx.doi.org/10.1590/1414-431x20175977
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
_version_ 1813002866555617280