Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/8773 http://dx.doi.org/10.1590/1414-431x20175977 |
Resumo: | Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide. |
id |
UFOP_e2e27c49a903e4fea9807a2b01290ada |
---|---|
oai_identifier_str |
oai:repositorio.ufop.br:123456789/8773 |
network_acronym_str |
UFOP |
network_name_str |
Repositório Institucional da UFOP |
repository_id_str |
3233 |
spelling |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.Gastric mucosaBone metabolismOsteoporosisRheumatoid arthritisGeneralized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.2017-09-22T12:48:47Z2017-09-22T12:48:47Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.1414-431Xhttp://www.repositorio.ufop.br/handle/123456789/8773http://dx.doi.org/10.1590/1414-431x20175977Os trabalhos publicados no periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, estão sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 31 jan. 2020.info:eu-repo/semantics/openAccessMaksud, Fabiana Alves NunesKakehasi, Adriana MariaGuimarães, M. F. B. R.Machado, Carla JorgeBarbosa, Alfredo José Afonsoengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2020-01-31T12:00:50Zoai:repositorio.ufop.br:123456789/8773Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-01-31T12:00:50Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
title |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
spellingShingle |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Maksud, Fabiana Alves Nunes Gastric mucosa Bone metabolism Osteoporosis Rheumatoid arthritis |
title_short |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
title_full |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
title_fullStr |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
title_full_unstemmed |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
title_sort |
Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. |
author |
Maksud, Fabiana Alves Nunes |
author_facet |
Maksud, Fabiana Alves Nunes Kakehasi, Adriana Maria Guimarães, M. F. B. R. Machado, Carla Jorge Barbosa, Alfredo José Afonso |
author_role |
author |
author2 |
Kakehasi, Adriana Maria Guimarães, M. F. B. R. Machado, Carla Jorge Barbosa, Alfredo José Afonso |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Maksud, Fabiana Alves Nunes Kakehasi, Adriana Maria Guimarães, M. F. B. R. Machado, Carla Jorge Barbosa, Alfredo José Afonso |
dc.subject.por.fl_str_mv |
Gastric mucosa Bone metabolism Osteoporosis Rheumatoid arthritis |
topic |
Gastric mucosa Bone metabolism Osteoporosis Rheumatoid arthritis |
description |
Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-22T12:48:47Z 2017-09-22T12:48:47Z 2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017. 1414-431X http://www.repositorio.ufop.br/handle/123456789/8773 http://dx.doi.org/10.1590/1414-431x20175977 |
identifier_str_mv |
MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017. 1414-431X |
url |
http://www.repositorio.ufop.br/handle/123456789/8773 http://dx.doi.org/10.1590/1414-431x20175977 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1813002866555617280 |