Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
dARK ID: | ark:/61566/001300000h9nb |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/9940 https://www.sciencedirect.com/science/article/pii/S0753332217351478 |
Resumo: | Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection. |
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Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.Candida sppFluconazoleBiodistributionNanocapsulesCandida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection.2018-05-15T14:12:04Z2018-05-15T14:12:04Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018. 07533322http://www.repositorio.ufop.br/handle/123456789/9940https://www.sciencedirect.com/science/article/pii/S0753332217351478ark:/61566/001300000h9nbAssis, Danielle Nogueira deAraújo, Raquel SilvaFuscaldi, Leonardo LimaDiniz, Simone Odília Antunes FernandesMosqueira, Vanessa Carla FurtadoCardoso, Valbert Nascimentoinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-11-11T06:21:46Zoai:repositorio.ufop.br:123456789/9940Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-11-11T06:21:46Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
title |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
spellingShingle |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Assis, Danielle Nogueira de Candida spp Fluconazole Biodistribution Nanocapsules |
title_short |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
title_full |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
title_fullStr |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
title_full_unstemmed |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
title_sort |
Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. |
author |
Assis, Danielle Nogueira de |
author_facet |
Assis, Danielle Nogueira de Araújo, Raquel Silva Fuscaldi, Leonardo Lima Diniz, Simone Odília Antunes Fernandes Mosqueira, Vanessa Carla Furtado Cardoso, Valbert Nascimento |
author_role |
author |
author2 |
Araújo, Raquel Silva Fuscaldi, Leonardo Lima Diniz, Simone Odília Antunes Fernandes Mosqueira, Vanessa Carla Furtado Cardoso, Valbert Nascimento |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Assis, Danielle Nogueira de Araújo, Raquel Silva Fuscaldi, Leonardo Lima Diniz, Simone Odília Antunes Fernandes Mosqueira, Vanessa Carla Furtado Cardoso, Valbert Nascimento |
dc.subject.por.fl_str_mv |
Candida spp Fluconazole Biodistribution Nanocapsules |
topic |
Candida spp Fluconazole Biodistribution Nanocapsules |
description |
Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-15T14:12:04Z 2018-05-15T14:12:04Z 2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018. 07533322 http://www.repositorio.ufop.br/handle/123456789/9940 https://www.sciencedirect.com/science/article/pii/S0753332217351478 |
dc.identifier.dark.fl_str_mv |
ark:/61566/001300000h9nb |
identifier_str_mv |
ASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018. 07533322 ark:/61566/001300000h9nb |
url |
http://www.repositorio.ufop.br/handle/123456789/9940 https://www.sciencedirect.com/science/article/pii/S0753332217351478 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1817705807101296640 |