Different infective forms trigger distinct immune response in experimental Chagas disease.
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
dARK ID: | ark:/61566/001300000ccqj |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/4257 https://doi.org/10.1371/journal.pone.0032912 |
Resumo: | Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface. Thus, aspects related to the variability that the forms of T. cruzi interacts with host cells may lead to fundamental implications on the immune response against this parasite and, consequently, the clinical evolution of Chagas disease. We have shown that BT infected mice presented higher levels of parasitemia during all the acute phase of infection. Moreover, the infection with either MT or BT forms resulted in increased levels of total leukocytes, monocytes and lymphocytes, specifically later for MT and earlier for BT. The infection with BT forms presented earlier production of proinflammatory cytokine TNF-a and later of IFN-c by both T cells subpopulations. This event was accompanied by an early cardiac inflammation with an exacerbation of this process at the end of the acute phase. On the other hand, infection with MT forms result in an early production of IFN-c, with subsequent control in the production of this cytokine by IL-10, which provided to these animals an immunomodulatory profile in the end of the acute phase. These results are in agreement with what was found for cardiac inflammation where animals infected with MT forms showed intense cardiac inflammation later at infection, with a decrease in the same at the end of this phase. In summary, our findings emphasize the importance of taking into account the inoculums source of T. cruzi, since vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during the acute phase that may influence relevant biological aspects of chronic Chagas disease. |
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Different infective forms trigger distinct immune response in experimental Chagas disease.Trypanosoma cruziChagas diseaseAlthough metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface. Thus, aspects related to the variability that the forms of T. cruzi interacts with host cells may lead to fundamental implications on the immune response against this parasite and, consequently, the clinical evolution of Chagas disease. We have shown that BT infected mice presented higher levels of parasitemia during all the acute phase of infection. Moreover, the infection with either MT or BT forms resulted in increased levels of total leukocytes, monocytes and lymphocytes, specifically later for MT and earlier for BT. The infection with BT forms presented earlier production of proinflammatory cytokine TNF-a and later of IFN-c by both T cells subpopulations. This event was accompanied by an early cardiac inflammation with an exacerbation of this process at the end of the acute phase. On the other hand, infection with MT forms result in an early production of IFN-c, with subsequent control in the production of this cytokine by IL-10, which provided to these animals an immunomodulatory profile in the end of the acute phase. These results are in agreement with what was found for cardiac inflammation where animals infected with MT forms showed intense cardiac inflammation later at infection, with a decrease in the same at the end of this phase. In summary, our findings emphasize the importance of taking into account the inoculums source of T. cruzi, since vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during the acute phase that may influence relevant biological aspects of chronic Chagas disease.2015-01-19T16:33:48Z2015-01-19T16:33:48Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfVIEIRA, P. M. de A. Different infective forms trigger distinct immune response in experimental Chagas disease. Plos One, v. 7, n. 3 p. e32912, 2012. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032912>. Acesso em: 12 ago. 2014.1932-6203http://www.repositorio.ufop.br/handle/123456789/4257https://doi.org/10.1371/journal.pone.0032912ark:/61566/001300000ccqjOs trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <https://www.plos.org/open-access>. Acesso em: 03 jan. 2017.info:eu-repo/semantics/openAccessVieira, Paula Melo de AbreuFranscisco, Amanda FortesMachado, Evandro Marques de MenezesNogueira, Nívia CarolinaFonseca, Kátia da SilvaReis, Alexandre BarbosaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisTafuri, Washington LuizCarneiro, Cláudia Martinsengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2024-11-10T23:39:38Zoai:repositorio.ufop.br:123456789/4257Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-11-10T23:39:38Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
title |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
spellingShingle |
Different infective forms trigger distinct immune response in experimental Chagas disease. Vieira, Paula Melo de Abreu Trypanosoma cruzi Chagas disease |
title_short |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
title_full |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
title_fullStr |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
title_full_unstemmed |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
title_sort |
Different infective forms trigger distinct immune response in experimental Chagas disease. |
author |
Vieira, Paula Melo de Abreu |
author_facet |
Vieira, Paula Melo de Abreu Franscisco, Amanda Fortes Machado, Evandro Marques de Menezes Nogueira, Nívia Carolina Fonseca, Kátia da Silva Reis, Alexandre Barbosa Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Tafuri, Washington Luiz Carneiro, Cláudia Martins |
author_role |
author |
author2 |
Franscisco, Amanda Fortes Machado, Evandro Marques de Menezes Nogueira, Nívia Carolina Fonseca, Kátia da Silva Reis, Alexandre Barbosa Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Tafuri, Washington Luiz Carneiro, Cláudia Martins |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Paula Melo de Abreu Franscisco, Amanda Fortes Machado, Evandro Marques de Menezes Nogueira, Nívia Carolina Fonseca, Kátia da Silva Reis, Alexandre Barbosa Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Tafuri, Washington Luiz Carneiro, Cláudia Martins |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Chagas disease |
topic |
Trypanosoma cruzi Chagas disease |
description |
Although metacyclic and blood trypomastigotes are completely functional in relation to parasite-host interaction and/or target cell invasion, they differ in the molecules present on the surface. Thus, aspects related to the variability that the forms of T. cruzi interacts with host cells may lead to fundamental implications on the immune response against this parasite and, consequently, the clinical evolution of Chagas disease. We have shown that BT infected mice presented higher levels of parasitemia during all the acute phase of infection. Moreover, the infection with either MT or BT forms resulted in increased levels of total leukocytes, monocytes and lymphocytes, specifically later for MT and earlier for BT. The infection with BT forms presented earlier production of proinflammatory cytokine TNF-a and later of IFN-c by both T cells subpopulations. This event was accompanied by an early cardiac inflammation with an exacerbation of this process at the end of the acute phase. On the other hand, infection with MT forms result in an early production of IFN-c, with subsequent control in the production of this cytokine by IL-10, which provided to these animals an immunomodulatory profile in the end of the acute phase. These results are in agreement with what was found for cardiac inflammation where animals infected with MT forms showed intense cardiac inflammation later at infection, with a decrease in the same at the end of this phase. In summary, our findings emphasize the importance of taking into account the inoculums source of T. cruzi, since vectorial or transfusional routes of T. cruzi infection may trigger distinct parasite-host interactions during the acute phase that may influence relevant biological aspects of chronic Chagas disease. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2015-01-19T16:33:48Z 2015-01-19T16:33:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
VIEIRA, P. M. de A. Different infective forms trigger distinct immune response in experimental Chagas disease. Plos One, v. 7, n. 3 p. e32912, 2012. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032912>. Acesso em: 12 ago. 2014. 1932-6203 http://www.repositorio.ufop.br/handle/123456789/4257 https://doi.org/10.1371/journal.pone.0032912 |
dc.identifier.dark.fl_str_mv |
ark:/61566/001300000ccqj |
identifier_str_mv |
VIEIRA, P. M. de A. Different infective forms trigger distinct immune response in experimental Chagas disease. Plos One, v. 7, n. 3 p. e32912, 2012. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0032912>. Acesso em: 12 ago. 2014. 1932-6203 ark:/61566/001300000ccqj |
url |
http://www.repositorio.ufop.br/handle/123456789/4257 https://doi.org/10.1371/journal.pone.0032912 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
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Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
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1817705789351002112 |