Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population

• Autor(a) principal: LIMA, Magaly do Bom Parto Lopes Vieira
• Data de Publicação: 2009
• Outros Autores: OLIVEIRA FILHO, Aldemir Branco de, CAMPOS, Júlia Furtado, MELO, Fárida Coeli de Barros Correia, NEVES, Washington Batista das, MELO, Raul Antônio Morais, LEMOS, José Alexandre Rodrigues de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFPA
• Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6876
• topic: Trombose venosa; Fator V Leiden; Sistema do grupo sanguíneo ABO; Pernambuco - Estado

Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.