Copaiba oil effect under different pathways in mice subjected to sepsis

Detalhes bibliográficos
Autor(a) principal: BOTELHO, Nara Macedo
Data de Publicação: 2014
Outros Autores: SILVEIRA, Edvaldo Lima, LOPES, Letícia Nobre, SANTOS, Felipe Augusto Folha, TEIXEIRA, Renan Kleber Costa, SILVA, Thaís Travassos da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6335
http://dx.doi.org/10.1590/S0102-86502014000800008
Resumo: PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
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spelling 2015-02-24T15:28:27Z2015-02-24T15:28:27Z2014-08BOTELHO, Nara Macedo et al. Copaiba oil effect under different pathways in mice subjected to sepsis. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 528-531, Aug. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000800008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6335. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/6335http://dx.doi.org/10.1590/S0102-86502014000800008PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoSILVEIRA, E. L. 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dc.title.en.fl_str_mv Copaiba oil effect under different pathways in mice subjected to sepsis
title Copaiba oil effect under different pathways in mice subjected to sepsis
spellingShingle Copaiba oil effect under different pathways in mice subjected to sepsis
BOTELHO, Nara Macedo
Plantas medicinais
Óleo de copaíba
Doenças peritoneais
Rato como animal de laboratório
Balsams
Peritoneal diseases
Ligation
Mice
title_short Copaiba oil effect under different pathways in mice subjected to sepsis
title_full Copaiba oil effect under different pathways in mice subjected to sepsis
title_fullStr Copaiba oil effect under different pathways in mice subjected to sepsis
title_full_unstemmed Copaiba oil effect under different pathways in mice subjected to sepsis
title_sort Copaiba oil effect under different pathways in mice subjected to sepsis
author BOTELHO, Nara Macedo
author_facet BOTELHO, Nara Macedo
SILVEIRA, Edvaldo Lima
LOPES, Letícia Nobre
SANTOS, Felipe Augusto Folha
TEIXEIRA, Renan Kleber Costa
SILVA, Thaís Travassos da
author_role author
author2 SILVEIRA, Edvaldo Lima
LOPES, Letícia Nobre
SANTOS, Felipe Augusto Folha
TEIXEIRA, Renan Kleber Costa
SILVA, Thaís Travassos da
author2_role author
author
author
author
author
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5088569652644480
http://lattes.cnpq.br/7986498092293019
http://lattes.cnpq.br/4734095669999459
http://lattes.cnpq.br/3144112004152037
http://lattes.cnpq.br/5246017785240786
http://lattes.cnpq.br/7391648610716249
dc.contributor.author.fl_str_mv BOTELHO, Nara Macedo
SILVEIRA, Edvaldo Lima
LOPES, Letícia Nobre
SANTOS, Felipe Augusto Folha
TEIXEIRA, Renan Kleber Costa
SILVA, Thaís Travassos da
dc.subject.por.fl_str_mv Plantas medicinais
Óleo de copaíba
Doenças peritoneais
Rato como animal de laboratório
topic Plantas medicinais
Óleo de copaíba
Doenças peritoneais
Rato como animal de laboratório
Balsams
Peritoneal diseases
Ligation
Mice
dc.subject.eng.fl_str_mv Balsams
Peritoneal diseases
Ligation
Mice
description PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS: Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutaneous group: submitted a CLP, and treat with copaiba oil by subcutaneous injection. After the death of the histological analysis were performed. The Kaplan-Meier curves of surviving time were realized. RESULTS: All animals that received copaiba, regardless of the route used, survived longer when compared to the control group (p<0.0001), whereas the survival time ranged from 20 hours for the control group up to 32 hours for the animals of gavage group and 52 for subcutaneous group. The animals that received gavage copaiba lived about and about 20 hours unless the subcutaneous group (p=0.0042). There was no statistical difference when compared the intensity of inflammatory response (p>0.05). CONCLUSION: Prophylactic subcutaneous administration of copaiba in mice subjected to severe sepsis by cecal ligation and puncture, resulted in a survival time higher than non-use or use of this oil by gavage.
publishDate 2014
dc.date.issued.fl_str_mv 2014-08
dc.date.accessioned.fl_str_mv 2015-02-24T15:28:27Z
dc.date.available.fl_str_mv 2015-02-24T15:28:27Z
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dc.identifier.citation.fl_str_mv BOTELHO, Nara Macedo et al. Copaiba oil effect under different pathways in mice subjected to sepsis. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 528-531, Aug. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000800008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6335. Acesso em:.
dc.identifier.uri.fl_str_mv http://repositorio.ufpa.br/jspui/handle/2011/6335
dc.identifier.issn.none.fl_str_mv 1678-2674
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0102-86502014000800008
identifier_str_mv BOTELHO, Nara Macedo et al. Copaiba oil effect under different pathways in mice subjected to sepsis. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 528-531, Aug. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000800008. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6335. Acesso em:.
1678-2674
url http://repositorio.ufpa.br/jspui/handle/2011/6335
http://dx.doi.org/10.1590/S0102-86502014000800008
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