Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab

Detalhes bibliográficos
Autor(a) principal: ALMEIDA, Izabela Negrão Frota de
Data de Publicação: 2015
Outros Autores: ALMEIDA, Luciana Negrão Frota de, SOBRINHO, Edmundo Frota de Almeida, GOMES, Bruno Duarte, SOUZA, Givago da Silva, ROSA, Alexandre Antonio Marques, SILVEIRA, Luiz Carlos de Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/10874
http://dx.doi.org/10.5935/0004-2749.20150027
Resumo: To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.
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spelling 2019-04-05T19:05:03Z2019-04-05T19:05:03Z2015-06-02ALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.0004-2749http://repositorio.ufpa.br/jspui/handle/2011/10874http://dx.doi.org/10.5935/0004-2749.20150027To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.Submitted by Amanda Garcia Gomes (amandagarcia.biblio2015@gmail.com) on 2019-04-05T12:19:11Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Article_OpticalCoherenceTomography.pdf: 689326 bytes, checksum: 73bec69f7a6f453d629218b88e46e7a5 (MD5)Approved for entry into archive by João Paulo Pastana Neves (joaopastana@ufpa.br) on 2019-04-05T19:05:03Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Article_OpticalCoherenceTomography.pdf: 689326 bytes, checksum: 73bec69f7a6f453d629218b88e46e7a5 (MD5)Made available in DSpace on 2019-04-05T19:05:03Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Article_OpticalCoherenceTomography.pdf: 689326 bytes, checksum: 73bec69f7a6f453d629218b88e46e7a5 (MD5) Previous issue date: 2015-06-02GOMES, Bruno Duarte. Universidade Federal do Pará, Instituto de Ciências Biológicas (ICB)engUniversidade Federal do ParáUFPABrasilArquivos Brasileiros de Oftalmologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492015000200010&lng=pt&nrm=isoreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAMacular degeneration/drug therapyAntibodiesTomography optical coherenceElectroretinographyIntravitreal injectionsOptical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumabTomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://lattes.cnpq.br/1740867152012675http://lattes.cnpq.br/2667980094488362http://lattes.cnpq.br/4949910049652505http://lattes.cnpq.br/4932238030330851http://lattes.cnpq.br/5705421011644718http://lattes.cnpq.br/4972772795172243http://lattes.cnpq.br/9383834641490219ALMEIDA, Izabela Negrão Frota deALMEIDA, Luciana Negrão Frota deSOBRINHO, Edmundo Frota de AlmeidaGOMES, Bruno DuarteSOUZA, Givago da SilvaROSA, Alexandre Antonio MarquesSILVEIRA, Luiz Carlos de Limainfo:eu-repo/semantics/openAccessORIGINALArticle_OpticalCoherenceTomography.pdfArticle_OpticalCoherenceTomography.pdfapplication/pdf689326https://repositorio.ufpa.br/oai/bitstream/2011/10874/1/Article_OpticalCoherenceTomography.pdf73bec69f7a6f453d629218b88e46e7a5MD51CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.pt_BR.fl_str_mv Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
dc.title.alternative.pt_BR.fl_str_mv Tomografia de coerência óptica e eletrorretinografia multifocal de pacientes com degeneração macular relacionada à idade, neovascular avançada, antes, durante e após o tratamento com ranibizumabe
title Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
spellingShingle Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
ALMEIDA, Izabela Negrão Frota de
Macular degeneration/drug therapy
Antibodies
Tomography optical coherence
Electroretinography
Intravitreal injections
title_short Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
title_full Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
title_fullStr Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
title_full_unstemmed Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
title_sort Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age related macular degeneration before, during, and after treatment with ranibizumab
author ALMEIDA, Izabela Negrão Frota de
author_facet ALMEIDA, Izabela Negrão Frota de
ALMEIDA, Luciana Negrão Frota de
SOBRINHO, Edmundo Frota de Almeida
GOMES, Bruno Duarte
SOUZA, Givago da Silva
ROSA, Alexandre Antonio Marques
SILVEIRA, Luiz Carlos de Lima
author_role author
author2 ALMEIDA, Luciana Negrão Frota de
SOBRINHO, Edmundo Frota de Almeida
GOMES, Bruno Duarte
SOUZA, Givago da Silva
ROSA, Alexandre Antonio Marques
SILVEIRA, Luiz Carlos de Lima
author2_role author
author
author
author
author
author
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1740867152012675
http://lattes.cnpq.br/2667980094488362
http://lattes.cnpq.br/4949910049652505
http://lattes.cnpq.br/4932238030330851
http://lattes.cnpq.br/5705421011644718
http://lattes.cnpq.br/4972772795172243
http://lattes.cnpq.br/9383834641490219
dc.contributor.author.fl_str_mv ALMEIDA, Izabela Negrão Frota de
ALMEIDA, Luciana Negrão Frota de
SOBRINHO, Edmundo Frota de Almeida
GOMES, Bruno Duarte
SOUZA, Givago da Silva
ROSA, Alexandre Antonio Marques
SILVEIRA, Luiz Carlos de Lima
dc.subject.por.fl_str_mv Macular degeneration/drug therapy
Antibodies
Tomography optical coherence
Electroretinography
Intravitreal injections
topic Macular degeneration/drug therapy
Antibodies
Tomography optical coherence
Electroretinography
Intravitreal injections
description To evaluate retinal morphology and function of patients with advanced neovascular age-related macular degeneration (AMD) before, during, and after treatment with ranibizumab. Methods: Twenty-one eyes diagnosed with advanced AMD were studied with optical coherence tomography (OCT) and multifocal electroretinography (mfERG). Three intravitreal injections of ranibizumab were administered at 1-month intervals. Evaluations were performed before the first injection (D0) and at 30 (D30), 60 (D60), and 90 days (D90) after the first injection and compared to an age-matched control group (n=21 eyes). Results: The thickness of macular retinal layers increased before treatment due to the presence of intraretinal fluid. A thick retinal pigment epithelium-choriocapillaris complex (RPE-CC) suggested the presence of choroidal neovascular membrane. Intraretinal edema decreased after treatment (P<0.01), but persisting RPE-CC thickness resulted in a subretinal scar. Three different annular retinal areas were studied with mfERG (from center to periphery: rings R1, R2, and R3). The amplitude of the first negative component (N1) decreased in R1, R2, and R3 at D30, D60, and D90 when compared with that in controls (P<0.05); the N1 implicit time was delayed in R3 at D30 (P<0.05). The amplitude of the first positive component (P1) was reduced in R1 and R2 at D30, D60, and D90 when compared with that in controls (P<0.01); the P1 implicit time was delayed in R1 at D0 and D60 (P<0.05), in R2 at D0, D30, and D90 (P<0.01), and in R3 at D30 and D60 (P<0.05). Conclusion: Ranibizumab reduces intraretinal edema, even in advanced cases. Central macular activity appeared to increase after the initiation of treatment, improving over time.
publishDate 2015
dc.date.issued.fl_str_mv 2015-06-02
dc.date.accessioned.fl_str_mv 2019-04-05T19:05:03Z
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dc.identifier.citation.fl_str_mv ALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.
dc.identifier.uri.fl_str_mv http://repositorio.ufpa.br/jspui/handle/2011/10874
dc.identifier.issn.pt_BR.fl_str_mv 0004-2749
dc.identifier.doi.pt_BR.fl_str_mv http://dx.doi.org/10.5935/0004-2749.20150027
identifier_str_mv ALMEIDA, Izabela Negrão Frota de et al. Optical coherence tomography and multifocal electroretinography of patients with advanced neovascular age-related macular degeneration before, during, and after treatment with ranibizumab. Arquivos Brasileiros Oftalmologia, São Paulo, v. 78, n. 2, p. 105-109, abr 2015. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10874. Acesso em:.
0004-2749
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http://dx.doi.org/10.5935/0004-2749.20150027
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