Influence of gender and estrous cycle in the forced swim test in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/3389 |
Resumo: | The present work aimed at studying the influence of the estrous cycle in the forced swim test, an animal model of depression. For this, 44 male and female Wistar rats were divided into five groups according to the hormonal state in the first day of the study: metaestrus (N = 12), diestrus (N = 8), proestrus (N = 7), estrous (N = 6) and males (N = 11). They were housed in groups of five, with water and food ad libitum under a 12/12 h light/dark cycle. Females were screened daily for the estrous cycle. The animals were subjected to two swimming sessions in a glass cylinder with water up to 15 cm at 28±2º C. The data of the first five minutes of a 15-min first session were compared to those of a 5-min second session 24 h later. The results indicate that the latency to the first immobility was substantially reduced in the second session and was longer for females in diestrus and proestrus in the first session. The results also indicate that females in diestrus and proestrus exhibited less immobility than males in the first session; females in diestrus also exhibited less immobility than females in metaestrus. Females in metaestrus and diestrus, as well as males, did not present the decrease in total immobility times in the second session. The present results are analyzed in terms of differential effects of progesterone and estrogen on a learning component and an affective component. |
id |
UFPA_dec42648389dc11a66a3ca4d3b9ae093 |
---|---|
oai_identifier_str |
oai:repositorio.ufpa.br:2011/3389 |
network_acronym_str |
UFPA |
network_name_str |
Repositório Institucional da UFPA |
repository_id_str |
2123 |
spelling |
2013-01-28T14:41:49Z2013-01-28T14:41:49Z2008-12GOUVEIA JR., Amauri et al. Influence of gender and estrous cycle in the forced swim test in rats. Psychology & Neuroscience. Rio de Janeiro, v. 1, n. 2, p. 191-197, jul./dez. 2008. Disponível em: <http://www.scielo.br/pdf/pn/v1n2/v1n2a12.pdf>. Acesso em: 25 jan. 2013. <http://dx.doi.org/10.3922/j.psns.2008.2.012>.1983-3288http://repositorio.ufpa.br/jspui/handle/2011/3389The present work aimed at studying the influence of the estrous cycle in the forced swim test, an animal model of depression. For this, 44 male and female Wistar rats were divided into five groups according to the hormonal state in the first day of the study: metaestrus (N = 12), diestrus (N = 8), proestrus (N = 7), estrous (N = 6) and males (N = 11). They were housed in groups of five, with water and food ad libitum under a 12/12 h light/dark cycle. Females were screened daily for the estrous cycle. The animals were subjected to two swimming sessions in a glass cylinder with water up to 15 cm at 28±2º C. The data of the first five minutes of a 15-min first session were compared to those of a 5-min second session 24 h later. The results indicate that the latency to the first immobility was substantially reduced in the second session and was longer for females in diestrus and proestrus in the first session. The results also indicate that females in diestrus and proestrus exhibited less immobility than males in the first session; females in diestrus also exhibited less immobility than females in metaestrus. Females in metaestrus and diestrus, as well as males, did not present the decrease in total immobility times in the second session. The present results are analyzed in terms of differential effects of progesterone and estrogen on a learning component and an affective component.engDiferenciação sexualCiclo estralInfluência de gêneroInfluence of gender and estrous cycle in the forced swim test in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGOUVEIA JUNIOR, AmauriAFONSECA, Taciana LucasOLIVEIRA, Caio Maximino deDOMINGUEZ, RobertoCARVALHO, Silvio Morato deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_InfluenceGenderEstrous.pdfArtigo_InfluenceGenderEstrous.pdfapplication/pdf391605http://repositorio.ufpa.br/oai/bitstream/2011/3389/1/Artigo_InfluenceGenderEstrous.pdf1bfbfdab400650146597ba30178ac6b2MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/3389/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52license_textlicense_texttext/html; charset=utf-80http://repositorio.ufpa.br/oai/bitstream/2011/3389/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823599http://repositorio.ufpa.br/oai/bitstream/2011/3389/4/license_rdf9e2b7f6edbd693264102b96ece20428aMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81996http://repositorio.ufpa.br/oai/bitstream/2011/3389/5/license.txt4b350777eea7a4b1ae7cd9a06fd687a1MD55TEXTArtigo_InfluenceGenderEstrous.pdf.txtArtigo_InfluenceGenderEstrous.pdf.txtExtracted texttext/plain38566http://repositorio.ufpa.br/oai/bitstream/2011/3389/6/Artigo_InfluenceGenderEstrous.pdf.txt6790515e79dace5cea630c29d52f14b6MD562011/33892017-10-16 12:57:38.171oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232017-10-16T15:57:38Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.pt_BR.fl_str_mv |
Influence of gender and estrous cycle in the forced swim test in rats |
title |
Influence of gender and estrous cycle in the forced swim test in rats |
spellingShingle |
Influence of gender and estrous cycle in the forced swim test in rats GOUVEIA JUNIOR, Amauri Diferenciação sexual Ciclo estral Influência de gênero |
title_short |
Influence of gender and estrous cycle in the forced swim test in rats |
title_full |
Influence of gender and estrous cycle in the forced swim test in rats |
title_fullStr |
Influence of gender and estrous cycle in the forced swim test in rats |
title_full_unstemmed |
Influence of gender and estrous cycle in the forced swim test in rats |
title_sort |
Influence of gender and estrous cycle in the forced swim test in rats |
author |
GOUVEIA JUNIOR, Amauri |
author_facet |
GOUVEIA JUNIOR, Amauri AFONSECA, Taciana Lucas OLIVEIRA, Caio Maximino de DOMINGUEZ, Roberto CARVALHO, Silvio Morato de |
author_role |
author |
author2 |
AFONSECA, Taciana Lucas OLIVEIRA, Caio Maximino de DOMINGUEZ, Roberto CARVALHO, Silvio Morato de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
GOUVEIA JUNIOR, Amauri AFONSECA, Taciana Lucas OLIVEIRA, Caio Maximino de DOMINGUEZ, Roberto CARVALHO, Silvio Morato de |
dc.subject.por.fl_str_mv |
Diferenciação sexual Ciclo estral Influência de gênero |
topic |
Diferenciação sexual Ciclo estral Influência de gênero |
description |
The present work aimed at studying the influence of the estrous cycle in the forced swim test, an animal model of depression. For this, 44 male and female Wistar rats were divided into five groups according to the hormonal state in the first day of the study: metaestrus (N = 12), diestrus (N = 8), proestrus (N = 7), estrous (N = 6) and males (N = 11). They were housed in groups of five, with water and food ad libitum under a 12/12 h light/dark cycle. Females were screened daily for the estrous cycle. The animals were subjected to two swimming sessions in a glass cylinder with water up to 15 cm at 28±2º C. The data of the first five minutes of a 15-min first session were compared to those of a 5-min second session 24 h later. The results indicate that the latency to the first immobility was substantially reduced in the second session and was longer for females in diestrus and proestrus in the first session. The results also indicate that females in diestrus and proestrus exhibited less immobility than males in the first session; females in diestrus also exhibited less immobility than females in metaestrus. Females in metaestrus and diestrus, as well as males, did not present the decrease in total immobility times in the second session. The present results are analyzed in terms of differential effects of progesterone and estrogen on a learning component and an affective component. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-12 |
dc.date.accessioned.fl_str_mv |
2013-01-28T14:41:49Z |
dc.date.available.fl_str_mv |
2013-01-28T14:41:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOUVEIA JR., Amauri et al. Influence of gender and estrous cycle in the forced swim test in rats. Psychology & Neuroscience. Rio de Janeiro, v. 1, n. 2, p. 191-197, jul./dez. 2008. Disponível em: <http://www.scielo.br/pdf/pn/v1n2/v1n2a12.pdf>. Acesso em: 25 jan. 2013. <http://dx.doi.org/10.3922/j.psns.2008.2.012>. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/3389 |
dc.identifier.issn.none.fl_str_mv |
1983-3288 |
identifier_str_mv |
GOUVEIA JR., Amauri et al. Influence of gender and estrous cycle in the forced swim test in rats. Psychology & Neuroscience. Rio de Janeiro, v. 1, n. 2, p. 191-197, jul./dez. 2008. Disponível em: <http://www.scielo.br/pdf/pn/v1n2/v1n2a12.pdf>. Acesso em: 25 jan. 2013. <http://dx.doi.org/10.3922/j.psns.2008.2.012>. 1983-3288 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/3389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFPA instname:Universidade Federal do Pará (UFPA) instacron:UFPA |
instname_str |
Universidade Federal do Pará (UFPA) |
instacron_str |
UFPA |
institution |
UFPA |
reponame_str |
Repositório Institucional da UFPA |
collection |
Repositório Institucional da UFPA |
bitstream.url.fl_str_mv |
http://repositorio.ufpa.br/oai/bitstream/2011/3389/1/Artigo_InfluenceGenderEstrous.pdf http://repositorio.ufpa.br/oai/bitstream/2011/3389/2/license_url http://repositorio.ufpa.br/oai/bitstream/2011/3389/3/license_text http://repositorio.ufpa.br/oai/bitstream/2011/3389/4/license_rdf http://repositorio.ufpa.br/oai/bitstream/2011/3389/5/license.txt http://repositorio.ufpa.br/oai/bitstream/2011/3389/6/Artigo_InfluenceGenderEstrous.pdf.txt |
bitstream.checksum.fl_str_mv |
1bfbfdab400650146597ba30178ac6b2 fd26723f8d7edacdb29e3f03465c3b03 d41d8cd98f00b204e9800998ecf8427e 9e2b7f6edbd693264102b96ece20428a 4b350777eea7a4b1ae7cd9a06fd687a1 6790515e79dace5cea630c29d52f14b6 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA) |
repository.mail.fl_str_mv |
riufpabc@ufpa.br |
_version_ |
1801771833732628480 |