Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy

Detalhes bibliográficos
Autor(a) principal: VIEIRA, José Luiz Fernandes
Data de Publicação: 2009
Outros Autores: GOMES, Andreza de Lourdes Souza, BORGES, Larissa Maria Guimarães, GUIMARÃES, Erika Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://www.repositorio.ufpa.br:8080/jspui/handle/2011/2426
Resumo: Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.
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spelling 2011-12-16T11:43:56Z2011-12-16T11:43:56Z2009-04VIEIRA, José L. F. et al. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 51, n. 2, p. 109-110, mar./abr. 2009. Disponível em: <http://www.scielo.br/pdf/rimtsp/v51n2/09.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S0036-46652009000200009.0036-4665http://www.repositorio.ufpa.br:8080/jspui/handle/2011/2426Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.engQuininaMalária falciparumCromatografiaAmazônia brasileiraRelationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapyRelação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária por Plasmodium falciparum não complicada em terapia via oralinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVIEIRA, José Luiz FernandesGOMES, Andreza de Lourdes SouzaBORGES, Larissa Maria GuimarãesGUIMARÃES, Erika Rodriguesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_RelationshipBetweenPlasma.pdfArtigo_RelationshipBetweenPlasma.pdfapplication/pdf90160http://repositorio.ufpa.br/oai/bitstream/2011/2426/1/Artigo_RelationshipBetweenPlasma.pdfa15084b6c40d65154bb016f7b5ddc616MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-852http://repositorio.ufpa.br/oai/bitstream/2011/2426/2/license_url3d480ae6c91e310daba2020f8787d6f9MD52license_textlicense_texttext/html; charset=utf-80http://repositorio.ufpa.br/oai/bitstream/2011/2426/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823892http://repositorio.ufpa.br/oai/bitstream/2011/2426/4/license_rdfafd5dad10b1d1e6dc10c8c5d25222c7aMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.ufpa.br/oai/bitstream/2011/2426/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55TEXTArtigo_RelationshipBetweenPlasma.pdf.txtArtigo_RelationshipBetweenPlasma.pdf.txtExtracted texttext/plain8508http://repositorio.ufpa.br/oai/bitstream/2011/2426/6/Artigo_RelationshipBetweenPlasma.pdf.txt33c378017c36e3d971a67c033231da9cMD562011/24262019-05-23 10:25:56.078oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232019-05-23T13:25:56Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false
dc.title.pt_BR.fl_str_mv Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
dc.title.alternative.pt_BR.fl_str_mv Relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária por Plasmodium falciparum não complicada em terapia via oral
title Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
spellingShingle Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
VIEIRA, José Luiz Fernandes
Quinina
Malária falciparum
Cromatografia
Amazônia brasileira
title_short Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
title_full Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
title_fullStr Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
title_full_unstemmed Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
title_sort Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy
author VIEIRA, José Luiz Fernandes
author_facet VIEIRA, José Luiz Fernandes
GOMES, Andreza de Lourdes Souza
BORGES, Larissa Maria Guimarães
GUIMARÃES, Erika Rodrigues
author_role author
author2 GOMES, Andreza de Lourdes Souza
BORGES, Larissa Maria Guimarães
GUIMARÃES, Erika Rodrigues
author2_role author
author
author
dc.contributor.author.fl_str_mv VIEIRA, José Luiz Fernandes
GOMES, Andreza de Lourdes Souza
BORGES, Larissa Maria Guimarães
GUIMARÃES, Erika Rodrigues
dc.subject.por.fl_str_mv Quinina
Malária falciparum
Cromatografia
Amazônia brasileira
topic Quinina
Malária falciparum
Cromatografia
Amazônia brasileira
description Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.
publishDate 2009
dc.date.issued.fl_str_mv 2009-04
dc.date.accessioned.fl_str_mv 2011-12-16T11:43:56Z
dc.date.available.fl_str_mv 2011-12-16T11:43:56Z
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dc.identifier.citation.fl_str_mv VIEIRA, José L. F. et al. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 51, n. 2, p. 109-110, mar./abr. 2009. Disponível em: <http://www.scielo.br/pdf/rimtsp/v51n2/09.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S0036-46652009000200009.
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identifier_str_mv VIEIRA, José L. F. et al. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 51, n. 2, p. 109-110, mar./abr. 2009. Disponível em: <http://www.scielo.br/pdf/rimtsp/v51n2/09.pdf>. Acesso em: 14 dez. 2011. http://dx.doi.org/10.1590/S0036-46652009000200009.
0036-4665
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