Estudo de estabilidade de medicamentos antibacterianos no âmbito hospitalar e identificação de vias de degradação.

• Autor(a) principal: Costa, Leonardo Wagner Maia da
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/572
• topic: ESTABILIDADE; FARMÁCIA HOSPITALAR; ANTIBACTERIANOS; QUÍMICA FARMACÊUTICA

All medications whether natural or synthetic change with time under the action of various environmental factors ( temperature, light , humidity ) . In this work are referred to the factors of which the stability participates , as well as the degradation processes more frequent. The decomposition of drugs requiring it is determined the period of its validity . Thus pharmaceutical companies estimate t he lifetime , in order to determine the amount of time that the medicine is in accordance with the specifications recommended by regulatory authorities . The process of determining the useful life of a drug is designated as stability analysis . The studies of the stability of drugs and medicines are designed , by means of mathematical and experimental models in order to provide insight into the mechanism of degradation and the estimated date of expiration ( half - life ) or another time for which obtain a ce rtain percentage of degradation. There are several factors that influence the stability of a drug , they being the extrinsic and intrinsic . In recent years Brazil in addition to an increase in medication use , there was also a need for greater control by the antibacterial , forcing pharmaceutical companies producing a good quality product , but also demanded more rigor in hospitals to control dispensing control and stability of drugs , since most of them require prior preparation for administration to pati ents, but they are the beneficiaries of the advancement in recent years of pharmaceutical care and pharmaceutical care within it , along with the hospital pharmacy brought to patient plus more security by having a multidisciplinary team with greater rigor forward to the effectiveness of the drugs . Much of these medications that require a previous dissolution in specific solvents , these in turn differ from each other as to the time of stability are closely related to the chemistry of the drug , as well as interaction with the excipients / diluents . In this work were treated major classes of antibacterial drugs most consumed in Brazil , but also through a literature review its main mechanisms and degradation products