Caracterização do estado sólido de dispersões sólidas de nifedipino obtidas por secagem por aspersão.

• Autor(a) principal: Baltazar, Lays de Oliveira
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/570
• topic: Ciências da Saúde: Farmácia; Nifedipino; Análise térmica; Estabilidade

The drug nifedipine p ractically insoluble in water used therapeutically as calcium antagonists for the treatment of angina and anti - hypertensive agent. This study aimed at the characterization studies of the solid state and thermal stability of nifedipine, as its solid dispers ions (SD) obtained by spray drying, investigating the physical interactions of the drug and the excipients, correlating the thermal data and X - ray diffraction, as well as the quantification of the drug released in the process of disoolução. For this purpos e, we use the thermal analysis Differential Scanning Calorimetry (DSC) DSC photovisual, Differential Thermal Analysis (DTA) and thermogravimetry (TG). Solid dispersions were prepared by spray drying with different excipients, sodium lauryl sulfate (SLS), p olyvinyl pyrrolidone (PVP), polyethylene glycol 400 and 6000 (PEG 400 and PEG 6000). Both the dynamic TG and DTA curves of excipients and SDs were obtained at heating rate 10 ° C min - 1. DSC curves showed the drug fusion occurring in the range reported in t he literature, while its dynamic TG and DTA curves show differences in the thermodecomposition temperature ranges with increasing ratio. It was observed that DS had a higher stability compared to the pure drug. The XRD patterns of the DS showed diffraction pattern of amorphous substance, unlike the pure drug. In dissolving the solid dispersion, both with PVP as the LSS resulted in increased dissolution of nifedipine (43% ± 1.06 and 18 ± 6.94% after 5 minutes, respectively) in the middle of USP phosphate buf fer pH 7.5, and means USP gastric fluid without enzyme pH 1.2 with 0.5% (w / v) Sodium Lauryl Sulfate (62.43% ± 7.01 and 27.90 ± 2.7 after 5 minutes) compared with dr ug (0.45 % ± 0.24 at 5 minutes).