Influência da composição corporal nos efeitos de um programa de treinamento físico sobre o perfil glicêmico, estresse oxidativo e inflamação sistêmica de diabéticos tipo 2: um ensaio clinico randomizado

• Autor(a) principal: Pereira, Valter Azevedo
• Data de Publicação: 2017
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/13057
• topic: Diabetes mellitus tipo 2; Exercício físico; Saúde; Type 2 diabetes mellitus; Exercise; Health; Diabetes mellitus tipo 2; Ejercicio; Salud; CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA

The outcomes of the diabetes is not only the hyperglycemia, but also the high levels of the oxidative stress and systemic inflammation promoting tissue damage. While this, body fat reduces glycemic control producing substances that inhibit periphery glucose absorption. On the other hand, training promotes glycemic control, decrease of oxidative stress and inflammation in these patients. However, any not studies evaluated if the body fat was an intervenient factor. The aim of this study was to determine, the influence of body fat on the effects promoted of a aerobic training program on glycemic profile, oxidative stress and systemic inflammation in type 2 diabetics patients. Twenty-two diabetics participated this study (13 men’s), 55,4±6 years old and BMI 29,1±5. They were randomly divided in exercise group (n=11) and control group (n=11). Volunteers of the exercise group participated the 12 weeks of aerobic training, 3 times a week, progressive volume (20 to 60 minutes) and progressive intensity (50% to 85% VO2máx). Before and after the program, the volunteers participated to a cardiorespiratory test, body composition evaluation with dual energy X-ray absorptiometry (DXA), fasting blood collect to analyze the glucose levels, glycosylated hemoglobin (Hb1ac), insulin, HOMA index, malondialdeído (MDA), total antioxidante capacity (CAT) and C reactive protein (PCR). Moreover, food consumption evaluates were perform at baseline, middle and end the program. New blood collects were performed every two weeks to accompany the blood glucose behavior. Data were analyzed by ANOVA two way test, with Bonferroni post hoc and linear correlation tests (Pearson or Spearman), following the data distribution. The training program promoted a significant increase of 12% on cardiorespiratory capacity (p=0,01), but, despite this improve, there was not modifications on body composition, fasting glucose (-25,4 mg/dl, p=0,78), Hb1ac (-0,10%, p=0,46), insulin (+0,38 UI/ml, p=0,20), HOMA index (-0,67, p=0,26), MDA (-0,16 µmol/L, p=0,65), CAT (-1,45%, p=0,61) e PCR (-0,36 mg/L, p=0,39). The control group showed reduction on fasting glucose (29,3 mg/dL, p=0,78), without difference to exercise group. For others variables did not had any significant alterations. Correlation tests using initial body composition and changes in the same variables with changes on glycemic profile, oxidative stress and systemic inflammation, showed relation between initial weight and change in MDA (r=0,62 e p=0,04), as well as among change in weigth and BMI and HOMA-IR (r=-0,87 e p=0,02). Twelve weeks of aerobic training improve the cardiorespiratory capacity of overweight/obesity type 2 diabetics, but do not improve the glycemic profile. Body adiposity not had influence on outcomes of the glycemic profile, oxidative stress and systemic inflammation after training.