Efeito da quimioterapia na percepção visual de mulheres mastectomizadas

• Autor(a) principal: Silva, Haydêe Cassé da
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/tede/7020
• topic: Drogas antineoplásicas; Quimioterapia; Percepção visual; Mastectomia; Função de sensibilidade ao contraste; Antineoplastic drugs; Chemotherapy; Visual perception; Mastectomy; Function of contrast sensitivity; CIENCIAS HUMANAS::PSICOLOGIA

The antineoplastic drugs used in systemic treatment of cancer by interfering with the mechanisms of survival, and cell migration proliferation. By systemic, these drugs can reach the central nervous system causing possible reactions in normal cells, including regions of the visual cortex, responsible for visual perception. The role of contrast sensitivity (FSC) has been used to characterize the process by which the visual system processes the information of the various frequencies of stimuli received by sensory stimuli perceived. So, this study aimed to investigate whether the agents of antineoplastic drugs can alter the sensory threshold in women that used for the systemic treatment of breast carcinoma, using the FSC as a tool. Respecting ethical aspects necessary to conduct the study, 20 volunteers participated in the tests, with normal or corrected visual acuity, ten users of antineoplastic drugs administered in six cycles of the FAC scheme - 5- fluorouracil, doxorubicin and cyclophosphamide (Experimental Group, EG) and ten volunteers without condition and without identifiable antineoplastics use of drugs (Control Group, CG). Measures of sensory threshold were performed at the Laboratory of Perception, Neuroscience and Behavior, using visual stimuli of spatial frequencies of 0.25, 1, 4 and 8 c/deg (cycle per degree of visual angle). The stimuli were generated in shades of gray and on a video monitor at 150 cm from the screen. It used to be an experimental design with repeated measures and put psychophysical forced-choice with two alternatives of choice. The procedure for measuring the sensitivity was the presentation of successive pairs of simple stimuli (test and neutral) and the volunteers were asked to choose among them always, that contained the frequency space. Three consecutive correct responses were necessary to reduce the amount of contrast in a indeed and an error to increase it (20%). Each frequency space was estimated twice for each participant, generating 240 values of thresholds for contrast. The data were grouped into tables and spreadsheets in Microsoft Office sociodemographic profile of the second sample, the iron values of contrast for maximum and minimum frequency space for the two groups.The analysis of variance for measures spread showed a significant difference between the threshold contrast of EG and the CG (F (1,238) = 23.97, p<0001), in the other words, there was variation in contrast sensitivity between the groups. At the highest spatial frequency (8 cpg) women in the control group were 1.6 more sensitive than the experimental group, analyzing how the post-hoc Tukey test (p<0001). You can guarantee, then, that the variation in contrast sensitivity among women of EG and CG can be caused, possibly by using the FAC scheme administered for the treatment of breast carcinoma. Therefore, the hypothesis that women mastectomized when subjected to treatment with drugs antineoplastics may have changed their visual perception is confirmed and accepted.