Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB

Detalhes bibliográficos
Autor(a) principal: Agripino, Gustavo Gomes
Data de Publicação: 2010
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/19550
Resumo: This study aimed to determine the epidemiological profile of salivary glands diseases and perform the reclassification of the salivary glands tumors diagnosed within the period from 2003 to 2009, in the referral hospital to cancer diagnosis and treatment of João Pessoa city, Paraíba State, according to World Health Organization’s classification/2005. A retrospective study was performed, by review of 181 cases of patients with lesions in the major and minor salivary glands, including 104 men (57.1%) and 78 women (42.9%), mean age 49 years. The malignant epithelial tumors were more prevalent in the sixth and seventh decades of life (n = 14, 65.2%) and benign in the fourth decade (n = 12, 30.8%). Regarding the location, the parotid gland was the preferably located of benign epithelial tumors (n = 29, 74.4%), malignant epithelial neoplasms were preferentially distributed in the minor glands (n = 13, 60.9%). The most frequent benign tumor was pleomorphic adenoma (n = 31, 79.4%), followed by Warthin's tumor (n = 3, 7.7%) and myoepithelioma (n = 3, 7.7%). The most prevalent malignant neoplasms were: adenocarcinoma NOS (n = 6, 26.1%), adenoid cystic carcinoma (n = 5, 21.7%) and mucoepidermoid carcinoma (n = 4; 17.4). Among the cases reviewed, 56 were reclassified (30.9%), and the tumor that suffered the greatest number of reclassification was adenocarcinoma NOS (n = 13; 23.2%). The scores of coincidence among original and revised diagnosis was "great" within the benign epithelial tumors (Kappa = 0.867, p <0.05); "good" within the epithelial malignant neoplasms (kappa = 0.693, p <0.05); within the haematolynphoid tumors (Kappa = 0.797, p <0.05) and secondary tumors (Kappa = 0.451, p <0.05) those scores was considered as "moderate"; finally, the scores was "perfect" for soft tissue tumors (Kappa = 1, 00, p <0.05). We conclude that the salivary gland diseases present significant prevalence into the studied population, and pleomorphic adenoma was the most prevalent benign epithelial tumor and adenocarcinoma NOS the main malignant variant.
id UFPB_ca5819c49e82d6817f607d819a858202
oai_identifier_str oai:repositorio.ufpb.br:123456789/19550
network_acronym_str UFPB
network_name_str Biblioteca Digital de Teses e Dissertações da UFPB
repository_id_str
spelling Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PBDoenças da bocaGlândulas salivaresNeoplasias das glândulas salivaresMouth diseasesSalivary glandsSalivary gland neoplasmsCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAThis study aimed to determine the epidemiological profile of salivary glands diseases and perform the reclassification of the salivary glands tumors diagnosed within the period from 2003 to 2009, in the referral hospital to cancer diagnosis and treatment of João Pessoa city, Paraíba State, according to World Health Organization’s classification/2005. A retrospective study was performed, by review of 181 cases of patients with lesions in the major and minor salivary glands, including 104 men (57.1%) and 78 women (42.9%), mean age 49 years. The malignant epithelial tumors were more prevalent in the sixth and seventh decades of life (n = 14, 65.2%) and benign in the fourth decade (n = 12, 30.8%). Regarding the location, the parotid gland was the preferably located of benign epithelial tumors (n = 29, 74.4%), malignant epithelial neoplasms were preferentially distributed in the minor glands (n = 13, 60.9%). The most frequent benign tumor was pleomorphic adenoma (n = 31, 79.4%), followed by Warthin's tumor (n = 3, 7.7%) and myoepithelioma (n = 3, 7.7%). The most prevalent malignant neoplasms were: adenocarcinoma NOS (n = 6, 26.1%), adenoid cystic carcinoma (n = 5, 21.7%) and mucoepidermoid carcinoma (n = 4; 17.4). Among the cases reviewed, 56 were reclassified (30.9%), and the tumor that suffered the greatest number of reclassification was adenocarcinoma NOS (n = 13; 23.2%). The scores of coincidence among original and revised diagnosis was "great" within the benign epithelial tumors (Kappa = 0.867, p <0.05); "good" within the epithelial malignant neoplasms (kappa = 0.693, p <0.05); within the haematolynphoid tumors (Kappa = 0.797, p <0.05) and secondary tumors (Kappa = 0.451, p <0.05) those scores was considered as "moderate"; finally, the scores was "perfect" for soft tissue tumors (Kappa = 1, 00, p <0.05). We conclude that the salivary gland diseases present significant prevalence into the studied population, and pleomorphic adenoma was the most prevalent benign epithelial tumor and adenocarcinoma NOS the main malignant variant.NenhumaA presente pesquisa teve como objetivo determinar o perfil epidemiológico das doenças das glândulas salivares e realizar a reclassificação das neoplasias das glândulas salivares, diagnosticadas no período de 2003 a 2009, no hospital de referência para o diagnóstico e tratamento do câncer da cidade de João Pessoa/PB, de acordo com a classificação da OMS/2005. Para tanto, foi realizado um estudo retrospectivo com revisão de 181 casos de pacientes com lesão em glândulas maiores e menores, sendo 104 homens (57,1%) e 78 mulheres (42,9%), com idade média 49 anos. Os tumores epiteliais malignos foram mais prevalentes na sexta e sétima décadas de vida (n=14; 65,2%) e os benignos na quarta década (n=12; 30,8%). Com relação à localização, a glândula parótida foi o sítio de preferência dos tumores epiteliais benignos (n=29; 74,4%); as neoplasias epiteliais malignas foram distribuídas preferencialmente nas glândulas menores (n=13; 60,9%). A neoplasia benigna mais freqüente foi o adenoma pleomórfico (n=31; 79,4%), seguido do tumor de Warthin (n=3; 7,7%) e mioepitelioma (n=3; 7,7%). Os representantes malignos mais prevalentes foram: o adenocarcinoma SOE (n=6; 26,1%); carcinoma adenóide cístico (n=5; 21,7%) e o carcinoma mucoepidermóide (n=4; 17,4). Dentre os casos revisados, 56 diagnósticos foram reclassificados (30,9%), sendo que a neoplasia que sofreu maior número de reclassificação foi o adenocarcinoma SOE (n=13, 23,2%). Os escores de coincidência entre diagnóstico original e revisado foi “ótimo” entre os tumores epiteliais benignos (Kappa=0,867, p<0,05); “bom” entre as neoplasias epiteliais malignas (Kappa=0,693, p<0,05) e tumores hematolinfóides (Kappa=0,797, p<0,05); foi ainda considerado “moderado” entre os tumores secundários (Kappa=0,451, p<0,05) e “perfeito” para a neoplasia das partes moles (Kappa=1,00, p<0,05). Conclui-se que as doenças das glândulas salivares apresentam prevalência significativa na população estudada, sendo o adenoma pleomórfico o tumor epitelial benigno mais prevalente e o adenocarcinoma SOE a principal variante maligna.Universidade Federal da ParaíbaBrasilOdontologiaPrograma de Pós-Graduação em OdontologiaUFPBFigueiredo, Claudia Roberta Leite dehttp://lattes.cnpq.br/9812014935249748Rosa, Marize Raquel Diniz dahttp://lattes.cnpq.br/2781775396459009Agripino, Gustavo Gomes2021-02-22T01:48:42Z2011-02-282021-02-22T01:48:42Z2010-08-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesishttps://repositorio.ufpb.br/jspui/handle/123456789/19550porhttp://creativecommons.org/licenses/by-nd/3.0/br/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFPBinstname:Universidade Federal da Paraíba (UFPB)instacron:UFPB2021-08-09T23:03:14Zoai:repositorio.ufpb.br:123456789/19550Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufpb.br/PUBhttp://tede.biblioteca.ufpb.br:8080/oai/requestdiretoria@ufpb.br|| diretoria@ufpb.bropendoar:2021-08-09T23:03:14Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)false
dc.title.none.fl_str_mv Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
title Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
spellingShingle Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
Agripino, Gustavo Gomes
Doenças da boca
Glândulas salivares
Neoplasias das glândulas salivares
Mouth diseases
Salivary glands
Salivary gland neoplasms
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
title_short Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
title_full Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
title_fullStr Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
title_full_unstemmed Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
title_sort Perfil epidemiológico das doenças das glândulas salivares e reclassificação das neoplasias de acordo com a OMS/2005, em João Pessoa/PB
author Agripino, Gustavo Gomes
author_facet Agripino, Gustavo Gomes
author_role author
dc.contributor.none.fl_str_mv Figueiredo, Claudia Roberta Leite de
http://lattes.cnpq.br/9812014935249748
Rosa, Marize Raquel Diniz da
http://lattes.cnpq.br/2781775396459009
dc.contributor.author.fl_str_mv Agripino, Gustavo Gomes
dc.subject.por.fl_str_mv Doenças da boca
Glândulas salivares
Neoplasias das glândulas salivares
Mouth diseases
Salivary glands
Salivary gland neoplasms
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
topic Doenças da boca
Glândulas salivares
Neoplasias das glândulas salivares
Mouth diseases
Salivary glands
Salivary gland neoplasms
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
description This study aimed to determine the epidemiological profile of salivary glands diseases and perform the reclassification of the salivary glands tumors diagnosed within the period from 2003 to 2009, in the referral hospital to cancer diagnosis and treatment of João Pessoa city, Paraíba State, according to World Health Organization’s classification/2005. A retrospective study was performed, by review of 181 cases of patients with lesions in the major and minor salivary glands, including 104 men (57.1%) and 78 women (42.9%), mean age 49 years. The malignant epithelial tumors were more prevalent in the sixth and seventh decades of life (n = 14, 65.2%) and benign in the fourth decade (n = 12, 30.8%). Regarding the location, the parotid gland was the preferably located of benign epithelial tumors (n = 29, 74.4%), malignant epithelial neoplasms were preferentially distributed in the minor glands (n = 13, 60.9%). The most frequent benign tumor was pleomorphic adenoma (n = 31, 79.4%), followed by Warthin's tumor (n = 3, 7.7%) and myoepithelioma (n = 3, 7.7%). The most prevalent malignant neoplasms were: adenocarcinoma NOS (n = 6, 26.1%), adenoid cystic carcinoma (n = 5, 21.7%) and mucoepidermoid carcinoma (n = 4; 17.4). Among the cases reviewed, 56 were reclassified (30.9%), and the tumor that suffered the greatest number of reclassification was adenocarcinoma NOS (n = 13; 23.2%). The scores of coincidence among original and revised diagnosis was "great" within the benign epithelial tumors (Kappa = 0.867, p <0.05); "good" within the epithelial malignant neoplasms (kappa = 0.693, p <0.05); within the haematolynphoid tumors (Kappa = 0.797, p <0.05) and secondary tumors (Kappa = 0.451, p <0.05) those scores was considered as "moderate"; finally, the scores was "perfect" for soft tissue tumors (Kappa = 1, 00, p <0.05). We conclude that the salivary gland diseases present significant prevalence into the studied population, and pleomorphic adenoma was the most prevalent benign epithelial tumor and adenocarcinoma NOS the main malignant variant.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-20
2011-02-28
2021-02-22T01:48:42Z
2021-02-22T01:48:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufpb.br/jspui/handle/123456789/19550
url https://repositorio.ufpb.br/jspui/handle/123456789/19550
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal da Paraíba
Brasil
Odontologia
Programa de Pós-Graduação em Odontologia
UFPB
publisher.none.fl_str_mv Universidade Federal da Paraíba
Brasil
Odontologia
Programa de Pós-Graduação em Odontologia
UFPB
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFPB
instname:Universidade Federal da Paraíba (UFPB)
instacron:UFPB
instname_str Universidade Federal da Paraíba (UFPB)
instacron_str UFPB
institution UFPB
reponame_str Biblioteca Digital de Teses e Dissertações da UFPB
collection Biblioteca Digital de Teses e Dissertações da UFPB
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)
repository.mail.fl_str_mv diretoria@ufpb.br|| diretoria@ufpb.br
_version_ 1801842969840451584