Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social

Detalhes bibliográficos
Autor(a) principal: Sousa, Gleiciano Rodrigo Morais de
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/20367
Resumo: Social anxiety disorder (SAD) is defined as a persistent fear or anxiety in one or more social situations in which the individual can be judged by others. It tends to start in childhood, shows a high level of comorbidities and is often confused with shyness, which is why it requires effective methods of evaluation and diagnosis. Although traditional treatments are effective, some patients with SAD are refractory, therefore, the search for new treatments is necessary. Transcranial direct current stimulation (tDCS) is a potential alternative whose clinical efficacy in psychiatric disorders is being studied. Thereby, this work aimed to develop two studies to assist in the investigation about the effects of tDCS from the ventromedial prefrontal cortex (vmPFC) on social anxiety. For this purpose, two articles were elaborated to compose the research, the first article was the development of a standardized tDCS intervention protocol in people with social anxiety, and the second was a case report that evaluated the effect and reliability of tDCS on the symptoms of social anxiety in a patient. For the development of the protocol, a review of the neuroimaging studies of the disorder and of those that used tDCS in patients with SAD was performed. In the second study, a protocol of five sessions with the duration of 20 minutes using tDCS at 2mA of intensity, with anodic and cathodic electrodes positioned in the left and right vmPFC respectively, was tested on a 25 year old female patient. As measures in the pre and post intervention, the Liebowitz Social Anxiety Scale, the Social Phobia Inventory, and the evaluation of heart rate variability under exposure to a behavioral task in virtual reality were used. As results of the first study, the development of the protocol was obtained, the results from the case report were positive, when considering the clinically observed reduction in anxiety symptoms in the patient, but further research is needed to analyze the external accuracy of the results. Protocol articles serve as a guide for future research, and in this work, it was possible to test the accuracy of the protocol developed from the case report. Works of this nature represent an important step towards understanding the therapeutic effects of tDCS and its adverse effects, and can assist researchers, health professionals and patients in understanding the neurophysiology of SAD.
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spelling Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade socialETCCTranstorno de ansiedade socialFobia socialVariabilidade da frequência cardíacaRealidade virtualtDCSSocial anxiety disorderSocial phobiaHeart rate variabilityVirtual realityCNPQ::CIENCIAS HUMANAS::PSICOLOGIASocial anxiety disorder (SAD) is defined as a persistent fear or anxiety in one or more social situations in which the individual can be judged by others. It tends to start in childhood, shows a high level of comorbidities and is often confused with shyness, which is why it requires effective methods of evaluation and diagnosis. Although traditional treatments are effective, some patients with SAD are refractory, therefore, the search for new treatments is necessary. Transcranial direct current stimulation (tDCS) is a potential alternative whose clinical efficacy in psychiatric disorders is being studied. Thereby, this work aimed to develop two studies to assist in the investigation about the effects of tDCS from the ventromedial prefrontal cortex (vmPFC) on social anxiety. For this purpose, two articles were elaborated to compose the research, the first article was the development of a standardized tDCS intervention protocol in people with social anxiety, and the second was a case report that evaluated the effect and reliability of tDCS on the symptoms of social anxiety in a patient. For the development of the protocol, a review of the neuroimaging studies of the disorder and of those that used tDCS in patients with SAD was performed. In the second study, a protocol of five sessions with the duration of 20 minutes using tDCS at 2mA of intensity, with anodic and cathodic electrodes positioned in the left and right vmPFC respectively, was tested on a 25 year old female patient. As measures in the pre and post intervention, the Liebowitz Social Anxiety Scale, the Social Phobia Inventory, and the evaluation of heart rate variability under exposure to a behavioral task in virtual reality were used. As results of the first study, the development of the protocol was obtained, the results from the case report were positive, when considering the clinically observed reduction in anxiety symptoms in the patient, but further research is needed to analyze the external accuracy of the results. Protocol articles serve as a guide for future research, and in this work, it was possible to test the accuracy of the protocol developed from the case report. Works of this nature represent an important step towards understanding the therapeutic effects of tDCS and its adverse effects, and can assist researchers, health professionals and patients in understanding the neurophysiology of SAD.NenhumaO transtorno de ansiedade social (TAS) é definido como medo ou ansiedade persistente em uma ou mais situações sociais nas quais o indivíduo pode ser avaliado por outras pessoas. Tende a ter início na infância, apresenta alto nível de comorbidades e frequentemente é confundido com timidez, por isso demanda métodos eficazes de avaliação e diagnóstico. Apesar dos tratamentos tradicionais serem eficazes, alguns pacientes com TAS são refratários, sendo assim, a busca por novos tratamentos é necessária. A estimulação transcraniana por corrente contínua (ETCC) figura-se como uma potencial alternativa cuja eficácia clínica nos transtornos psiquiátricos vem sendo estudada. Assim, este trabalho objetivou desenvolver dois estudos para auxiliar na investigação sobre os efeitos da ETCC do córtex pré-frontal ventromedial (CPFvm) na ansiedade social. Para isso, dois artigos foram elaborados para compor a pesquisa. O primeiro artigo foi o desenvolvimento de um protocolo de intervenção padronizado de ETCC em pessoas com ansiedade social, e o segundo foi um estudo de caso que avaliou o efeito e a confiabilidade da ETCC nos sintomas de ansiedade social em uma paciente. Para o desenvolvimento do protocolo, foi realizado uma revisão dos estudos de neuroimagem do transtorno e dos que utilizaram a ETCC em pacientes com TAS. No segundo estudo um protocolo de cinco sessões de 20min de ETCC a 2mA de intensidade, com os eletrodos anódicos e catódicos posicionados no CPFvm esquerdo e direito respectivamente, foi testado em uma paciente de 25 anos do sexo feminino. Foram utilizadas como medidas no pré e pós intervenção a Escala de Ansiedade Social de Liebowitz, o Inventário de Fobia Social, e a avaliação da variabilidade da frequência cardíaca sob exposição a uma tarefa comportamental em realidade virtual. Como resultados do primeiro estudo, foi obtido o desenvolvimento do protocolo, já os resultados oriundos do estudo de caso foram positivos, ao considerar a redução clinicamente observada dos sintomas ansiosos na paciente, mas novas pesquisas são necessárias para analisar a validade externa dos resultados. Artigos de protocolo servem como guia para pesquisas futuras, e neste trabalho foi possível testar a validade do protocolo desenvolvido a partir do estudo de caso. Trabalhos dessa natureza representam um passo importante para compreensão dos efeitos terapêuticos da ETCC e seus efeitos adversos, e podem auxiliar pesquisadores, profissionais da área da saúde e pacientes no entendimento da neurofisiologia do TAS.Universidade Federal da ParaíbaBrasilPsicologiaPrograma de Pós-Graduação em Neurociência Cognitiva e ComportamentoUFPBGaldino, Melyssa Kellyane Cavalcantihttp://lattes.cnpq.br/6286409609641742Machado, Sergio Eduardo de Carvalhohttp://lattes.cnpq.br/0095550072802463Sousa, Gleiciano Rodrigo Morais de2021-07-07T16:17:54Z2020-12-042021-07-07T16:17:54Z2020-11-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttps://repositorio.ufpb.br/jspui/handle/123456789/20367porhttp://creativecommons.org/licenses/by-nd/3.0/br/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFPBinstname:Universidade Federal da Paraíba (UFPB)instacron:UFPB2022-08-10T11:26:49Zoai:repositorio.ufpb.br:123456789/20367Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufpb.br/PUBhttp://tede.biblioteca.ufpb.br:8080/oai/requestdiretoria@ufpb.br|| diretoria@ufpb.bropendoar:2022-08-10T11:26:49Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)false
dc.title.none.fl_str_mv Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
title Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
spellingShingle Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
Sousa, Gleiciano Rodrigo Morais de
ETCC
Transtorno de ansiedade social
Fobia social
Variabilidade da frequência cardíaca
Realidade virtual
tDCS
Social anxiety disorder
Social phobia
Heart rate variability
Virtual reality
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA
title_short Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
title_full Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
title_fullStr Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
title_full_unstemmed Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
title_sort Efeitos da estimulação transcraniana por corrente contínua nos sintomas de ansiedade social
author Sousa, Gleiciano Rodrigo Morais de
author_facet Sousa, Gleiciano Rodrigo Morais de
author_role author
dc.contributor.none.fl_str_mv Galdino, Melyssa Kellyane Cavalcanti
http://lattes.cnpq.br/6286409609641742
Machado, Sergio Eduardo de Carvalho
http://lattes.cnpq.br/0095550072802463
dc.contributor.author.fl_str_mv Sousa, Gleiciano Rodrigo Morais de
dc.subject.por.fl_str_mv ETCC
Transtorno de ansiedade social
Fobia social
Variabilidade da frequência cardíaca
Realidade virtual
tDCS
Social anxiety disorder
Social phobia
Heart rate variability
Virtual reality
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA
topic ETCC
Transtorno de ansiedade social
Fobia social
Variabilidade da frequência cardíaca
Realidade virtual
tDCS
Social anxiety disorder
Social phobia
Heart rate variability
Virtual reality
CNPQ::CIENCIAS HUMANAS::PSICOLOGIA
description Social anxiety disorder (SAD) is defined as a persistent fear or anxiety in one or more social situations in which the individual can be judged by others. It tends to start in childhood, shows a high level of comorbidities and is often confused with shyness, which is why it requires effective methods of evaluation and diagnosis. Although traditional treatments are effective, some patients with SAD are refractory, therefore, the search for new treatments is necessary. Transcranial direct current stimulation (tDCS) is a potential alternative whose clinical efficacy in psychiatric disorders is being studied. Thereby, this work aimed to develop two studies to assist in the investigation about the effects of tDCS from the ventromedial prefrontal cortex (vmPFC) on social anxiety. For this purpose, two articles were elaborated to compose the research, the first article was the development of a standardized tDCS intervention protocol in people with social anxiety, and the second was a case report that evaluated the effect and reliability of tDCS on the symptoms of social anxiety in a patient. For the development of the protocol, a review of the neuroimaging studies of the disorder and of those that used tDCS in patients with SAD was performed. In the second study, a protocol of five sessions with the duration of 20 minutes using tDCS at 2mA of intensity, with anodic and cathodic electrodes positioned in the left and right vmPFC respectively, was tested on a 25 year old female patient. As measures in the pre and post intervention, the Liebowitz Social Anxiety Scale, the Social Phobia Inventory, and the evaluation of heart rate variability under exposure to a behavioral task in virtual reality were used. As results of the first study, the development of the protocol was obtained, the results from the case report were positive, when considering the clinically observed reduction in anxiety symptoms in the patient, but further research is needed to analyze the external accuracy of the results. Protocol articles serve as a guide for future research, and in this work, it was possible to test the accuracy of the protocol developed from the case report. Works of this nature represent an important step towards understanding the therapeutic effects of tDCS and its adverse effects, and can assist researchers, health professionals and patients in understanding the neurophysiology of SAD.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-04
2020-11-04
2021-07-07T16:17:54Z
2021-07-07T16:17:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufpb.br/jspui/handle/123456789/20367
url https://repositorio.ufpb.br/jspui/handle/123456789/20367
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal da Paraíba
Brasil
Psicologia
Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento
UFPB
publisher.none.fl_str_mv Universidade Federal da Paraíba
Brasil
Psicologia
Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento
UFPB
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFPB
instname:Universidade Federal da Paraíba (UFPB)
instacron:UFPB
instname_str Universidade Federal da Paraíba (UFPB)
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institution UFPB
reponame_str Biblioteca Digital de Teses e Dissertações da UFPB
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repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)
repository.mail.fl_str_mv diretoria@ufpb.br|| diretoria@ufpb.br
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