Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation
Main Author: | |
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Publication Date: | 2018 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Clinical and Biomedical Research |
Download full: | https://seer.ufrgs.br/index.php/hcpa/article/view/79507 |
Summary: | Introduction: Heart failure is a clinical syndrome characterized by sympathetic/ renin-angiotensin system activation, besides parasympathetic activity attenuation. In the initial phase of HF, following a myocardial infarction, there is impairment of the ventricular function and this can be influenced by the myocardium ischemia area in addition to alteration in the autonomic control of the heart. The aim of this study is to evaluate the hemodynamic responses and autonomic nervous system and its associations in infarcted rats by left coronary artery ligation.Methods: Forty male rats were submitted to left coronary artery ligation: infarcted animals with fifteen days from cardiac surgery (I15), infarcted animals with thirty days from cardiac surgery (I30) and sham-operated groups (S15 and S30), with 10 animals in each group. Basal hemodynamic data and heart rate variability (spectral analysis) were evaluated.Results: Compared to control groups, the infarcted rats demonstrated the following complications: a) cardiac hypertrophy (I30); b) pulmonary congestion (I30); c) mean arterial pressure (MAP), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) reduction; d) left ventricular systolic pressure (LVSP) reduction and left ventricular end-diastolic pressure (LVEDP) rise; e) contractile (+dP/dt) and relaxation derivatives (-dP/dt) reduction; f) sympathetic cardiac activity increase, and parasympathetic cardiac activity reduction (I30).Conclusion: Our study shows that the infarcted animals presented left ventricular dysfunction, which was influenced by the infarct size. In addition, impairment of autonomic control was present only in the animals belonging to the I30 group, probably due to the degree of cardiac decompensation and disease progression.Keywords: Heart failure; myocardial infarction; heart rate variability |
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Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligationHeart failuremyocardial infarctionheart rate variabilityIntroduction: Heart failure is a clinical syndrome characterized by sympathetic/ renin-angiotensin system activation, besides parasympathetic activity attenuation. In the initial phase of HF, following a myocardial infarction, there is impairment of the ventricular function and this can be influenced by the myocardium ischemia area in addition to alteration in the autonomic control of the heart. The aim of this study is to evaluate the hemodynamic responses and autonomic nervous system and its associations in infarcted rats by left coronary artery ligation.Methods: Forty male rats were submitted to left coronary artery ligation: infarcted animals with fifteen days from cardiac surgery (I15), infarcted animals with thirty days from cardiac surgery (I30) and sham-operated groups (S15 and S30), with 10 animals in each group. Basal hemodynamic data and heart rate variability (spectral analysis) were evaluated.Results: Compared to control groups, the infarcted rats demonstrated the following complications: a) cardiac hypertrophy (I30); b) pulmonary congestion (I30); c) mean arterial pressure (MAP), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) reduction; d) left ventricular systolic pressure (LVSP) reduction and left ventricular end-diastolic pressure (LVEDP) rise; e) contractile (+dP/dt) and relaxation derivatives (-dP/dt) reduction; f) sympathetic cardiac activity increase, and parasympathetic cardiac activity reduction (I30).Conclusion: Our study shows that the infarcted animals presented left ventricular dysfunction, which was influenced by the infarct size. In addition, impairment of autonomic control was present only in the animals belonging to the I30 group, probably due to the degree of cardiac decompensation and disease progression.Keywords: Heart failure; myocardial infarction; heart rate variabilityHCPA/FAMED/UFRGS2018-07-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/79507Clinical & Biomedical Research; Vol. 38 No. 2 (2018): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 38 n. 2 (2018): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/79507/pdfCopyright (c) 2018 Daniela Meirelles Nascimentoinfo:eu-repo/semantics/openAccessNascimento, Daniela MeirellesSchaan, Beatriz D'AgordBelló-Klein, AdrianeDal Lago, PedroIrigoyen, Maria Cláudia2024-01-19T14:23:02Zoai:seer.ufrgs.br:article/79507Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:23:02Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
title |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
spellingShingle |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation Nascimento, Daniela Meirelles Heart failure myocardial infarction heart rate variability |
title_short |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
title_full |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
title_fullStr |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
title_full_unstemmed |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
title_sort |
Hemodynamic changes and autonomic nervous system after acute myocardial infarction in rats submitted to left coronary artery ligation |
author |
Nascimento, Daniela Meirelles |
author_facet |
Nascimento, Daniela Meirelles Schaan, Beatriz D'Agord Belló-Klein, Adriane Dal Lago, Pedro Irigoyen, Maria Cláudia |
author_role |
author |
author2 |
Schaan, Beatriz D'Agord Belló-Klein, Adriane Dal Lago, Pedro Irigoyen, Maria Cláudia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nascimento, Daniela Meirelles Schaan, Beatriz D'Agord Belló-Klein, Adriane Dal Lago, Pedro Irigoyen, Maria Cláudia |
dc.subject.por.fl_str_mv |
Heart failure myocardial infarction heart rate variability |
topic |
Heart failure myocardial infarction heart rate variability |
description |
Introduction: Heart failure is a clinical syndrome characterized by sympathetic/ renin-angiotensin system activation, besides parasympathetic activity attenuation. In the initial phase of HF, following a myocardial infarction, there is impairment of the ventricular function and this can be influenced by the myocardium ischemia area in addition to alteration in the autonomic control of the heart. The aim of this study is to evaluate the hemodynamic responses and autonomic nervous system and its associations in infarcted rats by left coronary artery ligation.Methods: Forty male rats were submitted to left coronary artery ligation: infarcted animals with fifteen days from cardiac surgery (I15), infarcted animals with thirty days from cardiac surgery (I30) and sham-operated groups (S15 and S30), with 10 animals in each group. Basal hemodynamic data and heart rate variability (spectral analysis) were evaluated.Results: Compared to control groups, the infarcted rats demonstrated the following complications: a) cardiac hypertrophy (I30); b) pulmonary congestion (I30); c) mean arterial pressure (MAP), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) reduction; d) left ventricular systolic pressure (LVSP) reduction and left ventricular end-diastolic pressure (LVEDP) rise; e) contractile (+dP/dt) and relaxation derivatives (-dP/dt) reduction; f) sympathetic cardiac activity increase, and parasympathetic cardiac activity reduction (I30).Conclusion: Our study shows that the infarcted animals presented left ventricular dysfunction, which was influenced by the infarct size. In addition, impairment of autonomic control was present only in the animals belonging to the I30 group, probably due to the degree of cardiac decompensation and disease progression.Keywords: Heart failure; myocardial infarction; heart rate variability |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/79507 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/79507 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/79507/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Daniela Meirelles Nascimento info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Daniela Meirelles Nascimento |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 38 No. 2 (2018): Clinical and Biomedical Research Clinical and Biomedical Research; v. 38 n. 2 (2018): Clinical and Biomedical Research 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
_version_ |
1799767054592507904 |