Primary Aldosteronism

Detalhes bibliográficos
Autor(a) principal: Guimarães Camargo, Eduardo
Data de Publicação: 2008
Outros Autores: Bittencourt Detanico, Ana, Ortiz Pedrini, Renata, Pinho Silveiro, Sandra
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/2996
Resumo: Primary aldosteronism (PA) is a syndrome that results from adrenal autonomous secretion of aldosterone. The screening for this syndrome is indicated for individuals with arterial hypertension (AH) and spontaneous or severe hypocalemia after diuretics, and refractory AH (?3 antihypertensive agents). In this report, a male patient presented recent-onset diabetes mellitus (DM) and AH, weight lost, poliuria, polidipsia, and tiredness. Severe hypocalemia was present, and the laboratory workup confirmed the hypothesis of PA, with increased plasmatic and urinary aldosterone levels, low plasma renin activity and increased aldosterone/renin ratio. Adrenal computerized tomography showed a left adrenal adenoma. After the surgical procedure, blood pressure levels and glycemia were brought to normal. Though the prevalence of PA is not increased in patients with DM, it should be screened in patients with refractory AH or persistent hypocalemia. In patients with DM, cortisol metabolism should also be evaluated to rule the presence of hypercortisolism in a mixed adenoma.
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spelling Primary AldosteronismHiperaldosteronismo PrimáriohiperaldosteronismoHAPhipocalemiahipertensão arterial sistêmicadiabete melitoaldosteronaEndocrinologiaPrimary aldosteronism (PA) is a syndrome that results from adrenal autonomous secretion of aldosterone. The screening for this syndrome is indicated for individuals with arterial hypertension (AH) and spontaneous or severe hypocalemia after diuretics, and refractory AH (?3 antihypertensive agents). In this report, a male patient presented recent-onset diabetes mellitus (DM) and AH, weight lost, poliuria, polidipsia, and tiredness. Severe hypocalemia was present, and the laboratory workup confirmed the hypothesis of PA, with increased plasmatic and urinary aldosterone levels, low plasma renin activity and increased aldosterone/renin ratio. Adrenal computerized tomography showed a left adrenal adenoma. After the surgical procedure, blood pressure levels and glycemia were brought to normal. Though the prevalence of PA is not increased in patients with DM, it should be screened in patients with refractory AH or persistent hypocalemia. In patients with DM, cortisol metabolism should also be evaluated to rule the presence of hypercortisolism in a mixed adenoma.O hiperaldosteronismo primário (HAP) é uma síndrome decorrente do aumento da secreção autônoma de aldosterona pela glândula adrenal, independente do controle da renina. O rastreamento do HAP está indicado em indivíduos com hipertensão arterial sistêmica (HAS) e hipocalemia espontânea ou grave com doses moderadas de diuréticos ou HAS refratária ao tratamento (≥ 3 agentes anti-hipertensivos). No presente relato, paciente masculino apresentava diabete melito (DM) de início recente e HAS, emagrecimento, poliúria, polidipsia, e cansaço aos médios esforços. Apresentava hipocalemia grave e investigação laboratorial confirmou a suspeita de HAP, com medida de aldosterona sérica e urinária elevadas com diminuição da atividade da renina plasmática e aumento da razão aldosterona sérica/renina. Tomografia computadorizada de adrenais mostrou adenoma na adrenal esquerda. Após cirurgia, o paciente evoluiu com melhora dos níveis tensionais e normalização do metabolismo da glicose. Embora a prevalência de HAP em pacientes com DM não seja diferente da população de hipertensos não-diabéticos, a sua presença deve ser investigada nos casos de HAS refratária ou quando há hipocalemia. Em pacientes com DM, o metabolismo do cortisol também deve ser investigado para afastar a concomitância de hipercortisolismo decorrente de adenoma misto.HCPA/FAMED/UFRGS2008-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/2996Clinical & Biomedical Research; Vol. 28 No. 1 (2008): Revista HCPAClinical and Biomedical Research; v. 28 n. 1 (2008): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/2996/2594Guimarães Camargo, EduardoBittencourt Detanico, AnaOrtiz Pedrini, RenataPinho Silveiro, Sandrainfo:eu-repo/semantics/openAccess2020-01-16T16:15:43Zoai:seer.ufrgs.br:article/2996Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T16:15:43Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Primary Aldosteronism
Hiperaldosteronismo Primário
title Primary Aldosteronism
spellingShingle Primary Aldosteronism
Guimarães Camargo, Eduardo
hiperaldosteronismo
HAP
hipocalemia
hipertensão arterial sistêmica
diabete melito
aldosterona
Endocrinologia
title_short Primary Aldosteronism
title_full Primary Aldosteronism
title_fullStr Primary Aldosteronism
title_full_unstemmed Primary Aldosteronism
title_sort Primary Aldosteronism
author Guimarães Camargo, Eduardo
author_facet Guimarães Camargo, Eduardo
Bittencourt Detanico, Ana
Ortiz Pedrini, Renata
Pinho Silveiro, Sandra
author_role author
author2 Bittencourt Detanico, Ana
Ortiz Pedrini, Renata
Pinho Silveiro, Sandra
author2_role author
author
author
dc.contributor.author.fl_str_mv Guimarães Camargo, Eduardo
Bittencourt Detanico, Ana
Ortiz Pedrini, Renata
Pinho Silveiro, Sandra
dc.subject.por.fl_str_mv hiperaldosteronismo
HAP
hipocalemia
hipertensão arterial sistêmica
diabete melito
aldosterona
Endocrinologia
topic hiperaldosteronismo
HAP
hipocalemia
hipertensão arterial sistêmica
diabete melito
aldosterona
Endocrinologia
description Primary aldosteronism (PA) is a syndrome that results from adrenal autonomous secretion of aldosterone. The screening for this syndrome is indicated for individuals with arterial hypertension (AH) and spontaneous or severe hypocalemia after diuretics, and refractory AH (?3 antihypertensive agents). In this report, a male patient presented recent-onset diabetes mellitus (DM) and AH, weight lost, poliuria, polidipsia, and tiredness. Severe hypocalemia was present, and the laboratory workup confirmed the hypothesis of PA, with increased plasmatic and urinary aldosterone levels, low plasma renin activity and increased aldosterone/renin ratio. Adrenal computerized tomography showed a left adrenal adenoma. After the surgical procedure, blood pressure levels and glycemia were brought to normal. Though the prevalence of PA is not increased in patients with DM, it should be screened in patients with refractory AH or persistent hypocalemia. In patients with DM, cortisol metabolism should also be evaluated to rule the presence of hypercortisolism in a mixed adenoma.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/2996
url https://seer.ufrgs.br/index.php/hcpa/article/view/2996
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/2996/2594
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 28 No. 1 (2008): Revista HCPA
Clinical and Biomedical Research; v. 28 n. 1 (2008): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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