Calciuric levels in pregnant women with high blood pressure

• Autor(a) principal: L. Ramos, José Geraldo
• Data de Publicação: 2022
• Outros Autores: Martins-Costa, Sérgio, Vettorazzi-Stuczynski, Janete, Vettori, Daniela Vanessa, Louzado, Marcelo, Dornelles, Maria Stela, Bastos, Michel
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Clinical and Biomedical Research
• Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125275
• topic: Calciúria na gestação; pré-eclâmpsia; hipertensão na gestação; Calciuria in pregnancy; preeclampsia; pregnancy induced hypertension

OBJECTIVE: Arterial hypertension is one of the main causes of maternal and perinatalmorbimortality in Southern Brazil. Most studies concerning urinary calcium excretionduring pregnancy have found lower levels of calcium excretion in patients withpreeclampsia compared with normotensive pregnant patients and with pregnant patientswith preexisting chronic hypertension and without preeclampsia. The objective of thisstudy was to evaluate urinary calcium excretion in women with hypertensive disordersduring pregnancy.MATERIALS AND METHODS: All pregnant women who were hospitalized at the ObstetricCenter of the Hospital de Clínicas Teaching Hospital for increased blood pressure andbetween December 1998 and September 1999, were submitted to a protocol for collectionof demographic data, blood pressure data, and laboratory exams data (proteinuria;calciuria; and creatinuria from 24-h urine samples; proteinuria/creatinuria ratio; andserum uric acid). We determined hypocalciuria for urinary calcium excretion < 100 mg/24h and significant proteinuria for protein excretion > 300 mg/24h.RESULTS: The 71 patients studied presented averages of 26 years of age, 34 weeks ofgestation, and mean blood pressure of 151/98 mmHg. As to clinical development,35.2% of patients were diagnosed with preeclampsia, 8.5% with chronic hypertension,2.8% with eclampsia, 15.5% with preeclampsia over essential hypertension, 2.8% withHELLP syndrome, and 35.2% with transient hypertension. Patients with preeclampsiashowed 24-h calciuria significantly lower than that of patients with transient increase inblood pressure. There was no significant difference in 24-h calciuria from pregnantwomen with chronic hypertension and from women with preeclampsia.RESULTS: These results suggest that simple mensuration of urinary calcium excretioncan help diagnose hypertensive disorders during pregnancy.